(3-ETHOXYCARBONYLMETHYLPHENYL)BORONIC ACID, PINACOL ESTER

A solution of ethyl 2-(3-bromophenyl)acetate (1 g, 4.1 mmol) in dioxane (20 mL) was degassed with argon, to this solution (bis-pinacolato)diboron (1.25 g, 4.9 mmol), KOAc (1.20 g, 12.3 mmol) and Pd(dppf)To 2-(3-(4, 4, 5, 5-tetramethyl- 1 , 3, 2-dioxaborolan-2-yl)phenyl)acetic acid (0.5Og, 1.91 mmol) in 20 mis of dry DMF was added cesium carbonate (1.24 g, 3.82 mmole) and iodoethane (0.20 mis, 2.48 mmol). This mixture was stirred at room temperature for 16 hours, then diluted with brine, extracted twice with EtOAc, extracts washed with brine (2X), dried over sodium sulfate and concentrated under reduced pressure to give 360 mgs (65percent) of ethyl 2-(3-(4, 4, 5, 5- tetramethyl-l, 3, 2-dioxaborolan-2-yl)phenyl)acetate as a clear oil.

Molecular Weight:290.2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:290.1689394
Monoisotopic Mass:290.1689394
Topological Polar Surface Area:44.8
Heavy Atom Count:21
Complexity:365
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes