1H-Pyrazole-4-carboxylic acid, 3,5-dimethyl-, ethyl ester

To a solution of reagent 1 (4.6 mg, 26.7 mmol) in EtOH (50 mL) was added hydrazine hydrochloride (1.8 g, 26.7 mmol). The mixture was heated to reflux for 2 hours. The solvent was removed under reduced pressure and the residue was washed with EtOAc to give reagent 2 as a colorless solid (3.1 g, 69percent) sufficiently pure for the next step.To a solution of reagent 1 (4.6 mg, 26.7 mmol) in EtOH (50 mL) was added hydrazine hydrochloride (1.8 g, 26.7 mmol). The mixture was heated to reflux for 2 hours. The solvent was removed under reduced pressure and the residue was washed with EtOAc to give reagent 2 as a colorless solid (3.1 g, 69%) sufficiently pure for the next step.

Molecular Weight:168.19
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:168.089877630
Monoisotopic Mass:168.089877630
Topological Polar Surface Area:55
Heavy Atom Count:12
Complexity:172
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes