Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
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![Ethyl Imidazo[1,2-a]pyridine-3-carboxylate structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/c2e020452f8a4c1d9c9b70c735af02ed.png "Ethyl Imidazo[1,2-a]pyridine-3-carboxylate")
Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
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CAS No:
123531-52-2
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Formula:
C10H10N2O2
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Chemical Name:
Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
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Synonyms:
Ethyl Imidazo[1,2-a]pyridine-3-carboxylate;Imidazo[1,2-a]pyridine-3-carboxylicacid, ethyl ester
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CAS No:
Ethyl Imidazo[1,2-a]pyridine-3-carboxylate Basic Attributes
190.2
190.074234
DTXSID30559314
2933990090
Ethyl Imidazo[1,2-a]pyridine-3-carboxylate Use and Manufacturing
Ethyl imidazo[1, 2-a]pyridine-3-carboxylate(0.90 g, 4.7 mmol) and hydrazine (1.0 mL, 13 mmol, 40%) are combined in EtOH (10 mL). The mixture is stirred under microwave conditions at 100 C. for 2 hrs. The solvent is removed to give the title compound (0.82 g, 93%) which can be used without further purification. LC/MS (m/z): 177 (M+H).General procedure: To a soution of concentrated su'furic acid (1.2 mL, 24.0 rnmo) in absoute ethano (30 mL) was added potassium 2-choro-3-ethoxy-3-oxoprop-1-en-1-oate (8.55 g, 450 mmo) and (1.62 g, 15 mmo) and the mixture was heated under nitrogen at reflux for 18 hours. The mixture was coo'ed to ambent temperature and the resuWng suspension was evaporated to dryness under reduced pressure. Water (50 mL) was added to the residue and basfled w[th 2N NaOH (pH=85). The product was extracted wfth EtOAc (2x30 mL). The organic phase was dned and then evaporated. The resdue was punfled on sWca, euted w[th 0-100% EtOAc in petroeum ether to afford the tWe compound (1.42 g, 46%), (M+H=2O5.
Computed Properties
Molecular Weight:190.20
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:190.074227566
Monoisotopic Mass:190.074227566
Topological Polar Surface Area:43.6
Heavy Atom Count:14
Complexity:220
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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Ethyl Imidazo[1,2-a]pyridine-3-carboxylate
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