Agar

336.33500

336.14200

232-658-1

DTXSID9020037

Transparent strips or coarse or fine powder|Thin, translucent, membranous pieces, or pale buff powder|...usually in the form of chopped shreds, sheets, flakes, granules, or powder.

13023100

127.07000

-2.2

Agar agar is a tan powder. (NTP, 1992)

85-95 °C

SOLUBLE IN HOT WATER

Agar solutions are most stable at pH 4–10.
Agar should be stored in a cool, dry, place. Containers of this material may be hazardous when empty since they retain product residues (dust, solids).

LD50 orally in Rabbit: 11000 mg/kg

Odorless

Tasteless

DRIED HYDROPHILIC COLLOIDAL SUBSTANCE; RICH IN INDIGESTIBLE HEMICELLULOSE|GELS HAVE EXTREME HYSTERESIS LAG; GELS FORM @ 40-50 °C & DO NOT MELT UNLESS REHEATED TO 80-85 °C|GELS ARE EXTREMELY BRITTLE IN TEXTURE|For more Other Experimental Properties (Complete) data for AGAR-AGAR (11 total), please visit the HSDB record page.

Water insoluble.

Alcohols and Polyols

Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. They exhibit both weak acid and weak base behavior.

NONH for all modes of transport

2

22-36/37/38

26-36-24/25

AW7950000

Xn

Stable. Incompatible with strong oxidizing agents.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|Agar-agar used as a stabilizer in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.|Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

DHHS/NTP; Carcinogenesis Bioassay of Agar in F344 Rats and B6C3F1 Mice Technical Report Series No. 230 (1982) NIH Publication No 82-1786

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

LD50 Rat oral 11 g/kg|LD50 Mouse oral 16 g/kg|LD50 Rabbit oral 5800 mg/kg|LD50 Hamster oral 6100 mg/kg

A carcinogenesis bioassay of agar isolated from Pterocladia ... was conducted on groups of 50 F344 rats and 50 B6C3F1 mice of either sex which were fed diets containing 25,000 or 50,000 ppm of the test substance for 103 wk. Groups of 50 untreated rats and mice of either sex served as controls. ... Under the conditions of this bioassay, the agar isolated from Pterocladia was not carcinogenic for F344 rats or B6C3F1 mice of either sex. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

IT MAY BE EATEN AS A CEREAL SUBSTITUTE OR ADDED TO OTHER FOODS, OR IT MAY BE DISSOLVED IN HOT WATER & ALLOWED TO GEL BEFORE BEING TAKEN. HOWEVER, AGAR IS A RELATIVELY INEFFECTIVE BULK-FORMING AGENT IN THE USUAL DOSE OF 4 TO 16 G.|...ALSO EMPLOYED AS AN EMULSIFYING AGENT IN A VARIETY OF PROPRIETARY NOSTRUMS COMBINED WITH MINERAL OIL & OTHER CATHARTICS, BUT THE DOSE OF AGAR IN THESE PREPARATIONS IS TOO SMALL TO CONTRIBUTE TO THEIR LAXATIVE EFFECT.|MEDICATION (VET): LAXATIVE...USED IN CONSTIPATION.|MECHANISTIC STUDIES REVEALED ANTIPEPTIC EFFECT OF AGAR WAS DUE TO A SUBSTRATE-INHIBITOR INTERACTION WITH HEMOGLOBIN. POSSIBLE SIGNIFICANCE IN THE INHIBITORY EFFECT OF AGAR IN ULCER THERAPY.|For more Therapeutic Uses (Complete) data for AGAR-AGAR (6 total), please visit the HSDB record page.

1(?)= PRACTICALLY NON-TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QUART FOR 70 KG PERSON (150 LB). /GUMS, VEGETABLE/

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. (See all compounds classified as Culture Media.)

It passes through the intestinal tract mostly unabsorbed.

THESE SUBSTANCES DISSOLVE OR SWELL IN WATER TO FORM AN EMOLLIENT GEL OR VISCOUS SOLN THAT SERVES TO MAINTAIN THE FECES SOFT & HYDRATED. THE RESULTING BULK PROMOTES PERISTALSIS, & TRANSIT TIME IS REDUCED. /BULK-FORMING LAXATIVES/

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

ASIDE FROM AN OCCASIONAL ALLERGIC REACTION, THESE DRUGS CAN BE INGESTED IN LARGE AMT, WITH LITTLE DANGER OR DISTRESS EXCEPT FOR DIARRHEA, FLATULENCE, & RARELY FECAL IMPACTION. /GUMS, VEGETABLE/

Agar

ABOUT 38% AS AN INGREDIENT OF CULTURE MEDIA; 19% IN BAKED GOODS; 10% IN CONFECTIONS; 10% IN MEAT & POULTRY; 8% IN DESSERTS & BEVERAGES; 4% IN LAXATIVES & HEALTH FOODS; 4% IN PET FOODS; 3% IN IMPRESSION MATERIALS; 3% IN MISC APPLICATIONS; 1% IN PHARMACEUTICALS (1968)

Grades: technical; USP; FCC.

Agar: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).|Structure believed to be a complex range of polysaccharide chains having alternating alpha-(1,3) and beta-(1,4) linkages and varying in total charge content; three extremes of structure noted, namely neutral agarose, pyruvated agarose having little sulfation, and sulfated galactan...|SINCE AGAR IS COMPOSED OF AT LEAST TWO POLYMERIC ELECTROLYTES, THE PHOSPHATES SHOULD BE USEFUL IN IMPROVING ITS GELLING CHARACTERISTICS. ...DEMONSTRATED THAT THE GELLING STRENGTH OF THE AGAR GEL WAS SIGNIFICANTLY INCREASED BY...ADDITION OF 0.12-0.3% DSP.|AGAR WAS ALSO THE FIRST SEAWEED KNOWN TO BE EXTRACTED, PURIFIED, AND DRIED WHEN THE PROCESS WAS ACCIDENTALLY DISCOVERED BY A JAPANESE INNKEEPER ABOUT 1658. IT WAS INTRODUCED TO EUROPE AND THE UNITED STATES FROM CHINA IN THE NINETEENTH CENTURY...|CHEMICALLY, AGAR IS BELIEVED TO BE COMPOSED OF 3,6-ANHYDRO-L-GALACTOSE AND D-GALACTOPYRANOSE RESIDUES IN VARYING PROPORTIONS. THE TERM AGAR...HAS BEEN USED TO DESIGNATE BOTH THE DRIED EXTRACT AND THE SEAWEED SOURCE, BUT IT HAS BEEN PROPOSED THAT..."AGAROPHYTE" BE USED FOR THE WEED.|For more General Manufacturing Information (Complete) data for AGAR-AGAR (12 total), please visit the HSDB record page.

AOAC Method 945.57. Agar in Meat. Qualitative Test.

Food additives|Food Additives -> EMULSIFIER; STABILIZER; THICKENER; -> JECFA Functional Classes|Cosmetics -> Binding; Viscosity controlling

Food Additives -> EMULSIFIER; STABILIZER; THICKENER;