Triethylene glycol

150.17

150.17

969357

203-953-2

3P5SU53360

1160

60758

DTXSID4021393

Colorless liquid

29094919

58.9

-1.24/-1.9 (calculated)

Clear very slightly yellow Viscous Liquid

1.1274 g/cm³ @ Temp: 15 °C

-7 °C

165 °C @ Press: 14 Torr

165 °C

1.451

H2O: 50 mg/mL at 20 °C, clear, colorless

Store below +30°C.

<0.01 mm Hg ( 20 °C)

5.2 (vs air)

LD50 orl-rat: 17 g/kg JIHTAB 28,40,46

Lower flammable limit: 0.9% by volume; Upper flammable limit: 9.2% by volume

0.9-9.2%(V)

Practically odorless

Henry's Law constant = 2.61X10-10 atm-cu m/mol at 25 °C (est)

Hygroscopic|% in saturated air: approx 0.00013 at 20 °C; 1 ppm approx 6.14 mg/cu m at 25 °C, 760 mm Hg|Hydroxyl radical reaction rate constant = 3.64X10-11 cu cm/molec-sec at 25 °C (est)

Water soluble.

Alcohols and Polyols

TRIETHYLENE GLYCOL is a ether-alcohol derivative. The ether being relatively unreactive. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert alcohols to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides. Reacts with strong oxidants. [Handling Chemicals Safely 1980. p. 932].

700 °F (USCG, 1999)|700 °F (371 °C).|371 °C

Lower flammable limit: 0.9% by volume; Upper flammable limit: 9.2% by volume

61.04 kJ/mol at 101.3 kPa /=760 mm Hg/

NONH for all modes of transport

1

36/37/38

26-36

YE4550000

Xi

Stable. Combustible. Incompatible with strong oxidizing agents.

P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Can react with oxidizing materials.|Glycol ethers, glycols, ketones, and alcohols undergo violent decomposition in contact with 68-72% perchloric acid

Triethylene glycol is an indirect food additive for use only as a component of adhesives.

Cosmetic Ingredient Review Expert Panel; Final Report on the Safety Assessment of Triethylene Glycol and PEG-4. Int J Toxicol 25 (Supp 2): 121-38 (2006).|Ballantyne B and Snellings WM; Toxicology Update. Triethylene glycol HO(CH2CH3O)3H. J Appl Toxicol 27 (3): 291-9 (2007) reviews existing information on toxicity and related information on triethylene glycol.|USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Triethylene Glycol, EPA 739-R-05-002 (September 2005). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of March 8, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]|European Chemicals Bureau; IUCLID Dataset, Triethylene Glycol (112-27-6) p. 56/99 (2000 CD-ROM edition). Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of February 16, 2007.

This chemical is combustible. (NTP, 1992)|Combustible.

Not Classified| |Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should keep this material in a tightly closed container under an inert atmosphere, and store it at refrigerated temperatures. (NTP, 1992)

Goggles; plastic gloves. (USCG, 1999)

Combustible when exposed to heat or flame.|... It is stable chemically, does not present hazard due to flammability, except possibly at high temperatures or where fogs or mists are involved.

Explosive in the form of vapor when exposed to heat, flame, or spark.|Explosive limits , vol% in air: 0.9-9.2

Alcohol foam, dry chemical

Air Treatment: Do not use in nurseries or rooms where infants, ill or aged patients are confined; food, food contact surfaces and utensils should be protected from exposure to the spray or rinsed with ptable water before use. Spray away from drapes, walls, plastic, vinyl, painted or varnished surfaces.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

... /Irritant to/ ... eyes

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety spectacles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Triethylene glycol is produced, as an intermediate or final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

RURAL/REMOTE: Triethylene glycol was found in 5 of 25 aerosol samples taken from a light house site in northeastern Puerto Rico, and was identified in a sample taken 30 miles off the south coast(1).

Triethylene glycol (TEG) is a liquid higher glycol of very low vapor pressure with uses that are primarily industrial. It has a very low order of acute toxicity by iv, ip, peroral, percutaneous and inhalation (vapor and aerosol) routes of exposure. It does not produce primary skin iritation. Acute eye contact with the liquid causes mild local transient irritation (conjunctival hyperemia and slight chemosis) but does not induce corneal injury. Animal maximization and human volunteer repeated insult patch tests studies have shown that TEG does not cause skin sensitization. A study with Swiss-Webster mice demonstrated that TEG aerosol has properties of a peripheral chemosensory irritant material and caused a depression of breathing rate with an RD(50) of 5140 mg/ cu m. Continuous subchronic peroral dosing of TEG in the diet of rats did not produce any systemic cumulative or long-term toxicity. The effects seen were dose-related increased relative kidney weight, increased urine volume and decreased urine pH, probably a result of the renal excretion of TEG and metabolites following the absorption of large doses of TEG. There was also decreased hemoglobin concentration, decreased hematocrit and increased mean corpuscular volume, probably due to hemodilution following absorption of TEG. The NOAEL was 20,000 ppm TEG in diet. Short-term repeated aerosol exposure studies in the rat demonstrated that, by nose-only exposure, the threshold for effects by respiratory tract exposure was 1036 mg/cu m. Neither high dosage acute nor repeated exposures to TEG produce hepatorenal injury characteristic of that caused by the lower glycol homologues. Elimination studies with acute peroral doses of TEG given to rats and rabbits showed high recoveries (91-98% over 5 days), with the major fraction appearing in urine (84-94%) and only 1% as carbon dioxide. TEG in urine is present in unchanged and oxidized forms, but only negligible amounts as oxalic acid. Developmental toxicity studies with undiluted TEG given by gavage produced maternal toxicity in rats (body weight, food consumption, water consumption, and relative kidney weight) with a NOEL of 1126 mg/kg/day, and mice (relative kidney weight) with a NOEL of 5630 mg/kg/day. Developmental toxicity, expressed as fetotoxicity, had a NOEL of 5630 mg/kg/day with the rat and 563 mg/kg/day with mice. Neither species showed any evidence of embryotoxicity or teratogenicity. There was no evidence for reproductive toxicity with mice given up to 3% TEG in drinking water in a continuous breeding study. TEG did not produce mutagenic or clastogenic effects in the following in vitro genetic toxicology studies: Salmonella typhimurium reverse mutation test, SOS-chromotest in E. coli, CHO forward gene mutation test (HGPRT locus), CHO sister chromatid exchange test, and a chromosome aberration test with CHO cells. The use patterns suggest that exposure to TEG is mainly occupational, with limited exposures by consumers. Exposure is normally by skin and eye contact. Local and systemic adverse health effects by cutaneous exposure are likely not to occur, and eye contact will produce transient irritation without corneal injury. The very low vapor pressure of TEG makes it unlikely that significant vapor exposure will occur. Aerosol exposure is not a usual exposure mode, and acute aerosol exposures are unlikely to be harmful, although a peripheral sensory irritant effect may develop. However, repeated exposures to a TEG aerosol may result in respiratory tract irritation, with cough, shortness of breath and tightness of the chest. Recommended protective and precautionary measures include protective gloves, goggles or safety glasses and mechanical room ventilation. LC(50) data to various fish, aquatic invertebrates and algae, indicate that TEG is essentially nontoxic to aquatic organisms. Also, sustained exposure studies have demonstrated that TEG is of a low order of chronic aquatic toxicity. The bioconcentration potential, environmental hydrolysis, and photolysis rates are low, and soil mobility high. In the atmosphere TEG is degraded by reacting with photochemically produced hydroxyl radicals. These considerations indicate that the potential for ecotoxicological effects with TEG is low.

LD50 Mouse oral 18,500 mg/kg|LD50 Mouse iv 6,500 mg/kg|LD50 Mouse (female) ip 8.15 g/kg|LD50 Mouse sc 8,750 mg/kg|For more Non-Human Toxicity Values (Complete) data for TRIETHYLENE GLYCOL (21 total), please visit the HSDB record page.

Triethylene Glycol (TG) was tested for reproductive toxicity in Swiss CD-1 mice using the RACB protocol. It was part of a series of glycol ethers & congeners evaluated for structure-activity correlations using this design. Data collected on body weights, clinical signs, & food/water consumption during the dose-range-finding segment (Task 1) were used to set concns for the main study (Task 2) at 0.0, 0.3, 1.5%, & 3.0% in the drinking water. These concns gave calculated consumption estimates of 0.6, 3.3, & 6.8 g/kg/day. Two animals died in the control, middle dose group, & high dose group. TG consumption had no effect on the number of litters/pair delivered during Task 2, nor the number of live pups/litter. The mean live pup weight adjusted for litter size was reduced in the 1.5% & the 3.0% groups by 4% & 4.5%, respectively. The lack of change in the number of pups/litter or number of litters/pair led to the decision not to conduct Task 3 (the crossover mating to determine the affected sex). For the second generation, only the control & high dose groups were evaluated. For the wk before mating, when fluid consumption was measured, the treated mice consumed nearly equal to 16% more fluid than the controls. Nonetheless, there was no effect on the ability of the treated animals to mate or to deliver a litter of pups. Those litters had as many live pups as the controls, & the pups weighed the same (i.e., adjusted pup weight was not reduced by TG exposure). The F1 mice were killed & necropsied after the F2 pups were delivered & evaluated. Relative liver weight was increased by 5% & 6% in males & females, but there were no changes in body weight or other organ weights at necropsy in males or females. Epididymal sperm concn, motility, & morphology were unaffected by TG exposure at 3%. In summary, TG was not a reproductive toxicant in either generation of Swiss mice when administered in drinking water at concns of up to 3% /weight/volume/, although developmental toxicity was noted in the first generation as reduced pup body weight.

Triethylene glycol's production and use as a solvent, plasticizer in vinyl, polyester and polyurethane resins, as a humectant in printing inks, in the dehydration of natural gas(1) and as a fragrance ingredient in cosmetics(2) may result in its release to the environment through various waste streams; it's use as a bacteriostat and as an inert ingredient to facilitate delivery of formulated pesticide products(3) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol is expected to have very high mobility in soil(SRC). Volatilization of triethylene glycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.2X10-11 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Triethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.32X10-3 mm Hg(4). A series of aerobic river die-away tests which utilized several different sources of freshwater, suggest that rapid biodegradation is likely to be the most important removal mechanism of triethylene glycol from aerobic soil(SRC); degradation was complete within 7-11 days(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.2X10-11 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -1.75(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A series of aerobic river die-away tests, which utilized several differing sources of freshwater, suggest that rapid aerobic biodegradation is likely to be the most important removal mechanism of triethylene glycol from aquatic systems(SRC); degradation was complete within 7-11 days(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triethylene glycol, which has a vapor pressure of 1.32X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase triethylene glycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 11 hours(SRC), calculated from its rate constant of 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Alcohols and ethers do not absorb light at wavelengths >290 nm and therefore triethylene glycol is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of triethylene glycol with photochemically-produced hydroxyl radicals has been estimated as 3.6X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 11 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Triethylene glycol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2,3). Alcohols and ethers do not absorb light at wavelengths >290 nm and therefore triethylene glycol is not expected to be susceptible to direct photolysis by sunlight(4).

An estimated BCF of 3 was calculated in fish for triethylene glycol(SRC), using an estimated log Kow of -1.75(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of triethylene glycol can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that triethylene glycol is expected to have very high mobility in soil(SRC).

The Henry's Law constant for triethylene glycol is estimated as 3.2X10-11 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that triethylene glycol is expected to be essentially nonvolatile from water surfaces(2). Triethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.32X10-3 mm Hg(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 233,613 workers (53,367 of these are female) are potentially exposed to triethylene glycol in the US(1). Occupational exposure to triethylene glycol may occur through inhalation and dermal contact with this compound at workplaces where triethylene glycol is produced or used(SRC). Monitoring and use data indicate that the general population may be exposed to triethylene glycol via inhalation of ambient air, and dermal contact with products containing triethylene glycol(SRC).

Four male albino rats weighing 112 to 145 g were given a single oral dose of 22.5 mg randomly radiolabeled 14-C-triethylene glycol. The rats were then placed in a metabolic chamber in which urine, feces, and expired air were collected over a period of 5 days. The radioactivity recovered (in percent of the administered dose) amounted to 0.8 to 1.2% in expired air, 2.0 to 5.3% in feces, and 86.1 to 94.0% in urine. The total recovery of radioactivity was 90.6% to 98.3% of the administered dose.|Following oral dosing, the rat and rabbit excreted most of the triethylene glycol in both unchanged and/or oxidized forms (mono- and dicarboxylic acid derivatives of triethylene glycol). In rabbits dosed with 200 or 2000 mg/kg triethylene glycol respectively excreted 34.3% or 28%, of the administered dose in the urine as unchanged triethylene glycol and 35.2% as a hydroxyacid form of this chemical. In the studies with rats, little if any 14-C-oxalate or 14-C-triethylene glycol in conjugated form was found in the urine. Trace amounts of orally administered 14-C triethylene glycol were excreted in expired air as carbon dioxide (<1%) and in detectable amounts in feces (2 to 5 %). The total elimination of radioactivity (urine, feces and CO2) during the five day period following an oral dose of labeled compound (22.5 mg) ranged from 91 to 98%. The majority of the radioactivity appeared in the urine.|No studies have been reported dealing with the skin absorption of triethylene glycol. Although it is possible that under conditions of very severe prolonged exposures to this chemical, absorption through the skin can occur, it is doubtful any appreciable systemic/dermal injury would occur because triethylene glycol has (1) a low order of dermal irritancy, (2) is not a dermal sensitizer, and (3) showed no evidence of dermal or systemic toxicity following repeated dermal applications of 2 mL (approximately 600 mg/kg) triethylene glycol applied to the skin of rabbits in a 21-day dermal toxicity study.

Two female New Zealand white rabbits triethylene glycol by stomach tube. Urine from the dosed animals was subsequently collected for 24 hrs. Rabbits dosed with 200 or 2,000 mg/kg respectively excreted 34.3% or 28% of the dose amount as unchanged triethylene glycol. The urine of one rabbit contained 35.2% of the administered dose as a hydroxyacid form of triethylene glycol.|Triethylene glycol is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. Triethylene glycol metabolism by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.|... Eliminated ... possibly as mono- and dicarboxylic acid derivatives or triethylene glycol. In studies with rats, little if any 14-C-oxalate or 14-C-triethylene glycol in conjugated form was found in urine.

Commercial grade triethylene glycol has been found to contain <1 ppm dioxane. Twenty-six samples of 99.9% pure triethylene glycol were found to contain 0.02 to 0.13% diethylene glycol.

Vapor and liquid are unlikely to cause harm. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Ethylene glycol, glycols, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema... . Monitor cardiac rhythm and treat arrhythmias if necessary... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload... . Treat seizures with diazepam or lorazepam... . Use proparacaine hydrochloride to assist eye irrigation... . /Ethylene glycol, glycols, and related compounds/

/SIGNS AND SYMPTOMS/ Splash contamination in man ... causes acute smarting, & this may be followed by transitory disturbance of corneal epithelium with gradually diminishing sensation & signs of irritation, but no persistent injury is to be expected.|/HUMAN EXPOSURE STUDIES/ ...Evaluated 20% triethylene glycol in petrolatum in human volunteers; and the chemical was not a sensitizer.|/HUMAN EXPOSURE STUDIES/ 20% triethylene glycol in petrolatum was described as not irritating in a patch test evaluated at 48 hr.|/CASE REPORTS/ A 23-yr-old woman was brought to an emergency room after intentionally ingesting one gulp (volume unspecified) of ... brake fluid. ...The patient was given milk to drink by her family and subsequently vomited. Upon arrival to the emergency room, she was unconscious and had metabolic acidoses (pH 7.03, PCO2 44 mmHg, bicarbonate 11 mmol/L, anion gap 30 mmol/L, serum creatinine 90 umol/L). She was intubated and given 100 mmol of iv sodium bicarbonate. Triethylene glycol is thought to be metabolized by alcohol dehydrogenase to acidic products resulting in metabolic acidosis. To act as a competitor of the alcohol dehydrogenase enzyme, ethanol was administered to maintain a serum ethanol level of 100 mg/dL. The blood pH returned to normal over the next 8 hrs, and ethanol infusion was continued for 22 hr. At 36 hr post ingestion, the patient was discharged to a psychiatric ward. Analysis of blood drawn upon admission did not detect the presence of ethanol, ethylene glycol, methanol... . The above case study described the... brake fluid as 99.9% triethylene glycol. The material safety data sheet for /this brand of/ brake fluid, however, lists its ingredients as 30-60% polyglycol ethers; 30-60% borate of triethylene glycol monomethyl ether; 30-60% polyglycol; 0-10% corrosion inhibitor; and 0-10% dye.|For more Human Toxicity Excerpts (Complete) data for TRIETHYLENE GLYCOL (6 total), please visit the HSDB record page.

triethylene glycol

The substance can be absorbed into the body by inhalation of its vapour.

Natural gas dehydration, 60%; vinyl plasticizer, 12%; polyester resins and polyols, 9%; solvents, 11%; humectants, 5%; miscellaneous, 3%|CHEMICAL PROFILE: Triethylene glycol. Demand: 1986: 110 million lb; 1987: 110 million lb; 1991 /projected/: 115 million lb.|CHEMICAL PROFILE: Triethylene glycol. Demand: 1989: 115 million lb; 1990 /projected/: 117 million lb; 1994 /projected/: 127 million lb. (Includes exports; imports are negligible.)

Udex grades /Dow Chemical/|Clear liquid grades 99% /Eastman Chemical/|Grade: Technical, CP.

Adhesive manufacturing|Ethanol, 2,2'-[1,2-ethanediylbis(oxy)]bis-: ACTIVE|Triethylene glycol is described as an oligomer of ethylene glycol. So-called polyglycols are higher molecular weight adducts of ethylene oxide and distinguised by intervening ether linkages in the hydrocarbon chain.|After years of study, triethylene glycol was found to be the ideal chemical for aerial disinfection in sterile filling units because it had a high bactericidal potency at reasonable cost and was non-toxic. It was most effective at relative humidities of 30 to 55% and the rate of kill increased with temperature and degree of saturation of air with the vapor.

IN ... TOBACCO, BY GAS CHROMATOGRAPHY.|MONO-, DI-, & TRIETHYLENE GLYCOL IN WASTE WATERS (TOTAL CONCN 0.06-0.2%) DETERMINED BY GAS-LIQUID CHROMATOGRAPHY.|EPA-B Method PMD-WTY. Determination of Triethylene Glycol by Gas Chromatography (TCD-Internal Standard).|Method: NIOSH 5523, Issue 1; Procedure: gas chromatography with a flame ionization detector; Analyte: triethylene glycol; Matrix: air; Detection Limit: 14 ug/sample.|For more Analytic Laboratory Methods (Complete) data for TRIETHYLENE GLYCOL (6 total), please visit the HSDB record page.

Triethylene glycol has been determined by gas chromatography-mass spectormetry and gas-liquid chromatography. Triethylene glycol has been measured in rat and rabbit urine using vapor phase chromatography and colorimetry.

EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Cosmetics -> Solvent