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Silicon dioxide

pharmaceutical raw materials
Silicon dioxide structure

Silicon dioxide 

structure
  • CAS No:

    7631-86-9

  • Formula:

    O2Si

  • Chemical Name:

    Silicon dioxide

  • Synonyms:

    SILICA GEL 60 PF254 FOR PREPARATIVE LAYE;LICHROSORB SI 100 (10 MYM) 10 G;TLC-SILICA GEL 60 GF254 MEAN PARTICLE SI;LICHROSORB SI 100 (10 MYM) 100 G;SEA SAND EXTRA PURE 5 KG;SILICA GEL 60 GF254 FOR THIN-LAYER CHROM;SILICA GEL 60 PF254 + 366 FOR PREPARATIV;SEA SAND EXTRA PURE 25 KG

  • Categories:

    Cosmetic Ingredient  >  Viscosity Controlling

Description

Diatomaceous earth is a transparent to gray, odorless amorphous powder. Amorphous silica, the noncrystalline form of SiO2, is a transparent to gray, odorless, amorphous powder white crystals or powder


Silicon dioxide occurs almost everywhere on earth. It is one of the most important and abundant oxides on earth, constituting about 60% weight of the earth’s crust as silica itself or in combination with other metal oxides in silicates. It commonly is found as sand in the vast ocean and river shores, their beds, deserts, rocks, and minerals.Silicon dioxide exists in several structural forms: polymorphic crystalline silica, synthetic quartz crystals, amorphous silica, and vitreous silica. This classification is not complete as there are other forms of silica synthesized for specialized applications.


Silica is an inert, naturally occurring mineral used as a carrier in some pesticide products and is sometimes used as an insecticide to control crawling insects, acting via its abrasive and desiccant properties. It is moderately soluble in water and stable in the environment. It is generally considered non-toxic to biodiversity and humans. However, there are some concerns that exposure to crystalline silica particles that are small enough to reach the lungs can cause lung cancer.


white crystals or powder


ChEBI: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.

Silicon dioxide Basic Attributes

60.08

60.08

231-545-4

TSCA listed

White to yellow

2811221000

Characteristics

34.14000

Colorless amorphous (i.e., fused silica) or crystalline (i.e., quartz) material having a low thermal expansion coefficient and excellent optical transmittance in far UV. Silica is insoluble in strong mineral acids and alkalis except HF, concentrated H3PO4, NH4HF2, concentrated alkali metal hydroxides. Owing to its good corrosion resistance to liquid metals such as Si, Ge, Sn, Pb, Ga, In, Tl, Rb, Bi, and Cd, it is used as crucible container for melting these metals, while silica is readily attacked in an inert atmosphere by molten metals such as Li, Na, K Mg, and Al. Quartz crystals are piezoelectric and pyroelectric. Maximum service temperature 1090°C.

-0.61840

White to yellow suspension

2.2-2.6 g/mL at 25 °C

>1600 °C(lit.)

>100 °C(lit.)

2230°C

1.46

insoluble

Refrigerator (+4°C)

13.3hPa at 1732℃

LC inhalation in rat: > 200gm/m3/1H

Noncombustible Solid

Silica gel at -78 deg C adsorbs 4.5 wt % of ozone, and below this temperature the concentration increases rapidly. At below -112 deg C ozone liquefies and there is a potential explosion hazard at temperatures below -100 deg C if organic material is present.

at 100.00%. odorless

Tasteless

5-8 (100g/l, H2O, 20℃)(slurry)

6.65-9.8[at 20 ℃]

2-8°C

Safety Information

NONH for all modes of transport

nwg

Xn,Xi

26-37/39-36-36/37/39-36/37-61

VV8853000

Xn,Xi

Separated from strong oxidants.

Stable.

P261-P305 + P351 + P338

Not toxic if ingested, inhaled silica dust can cause silicosis; carcinogen.

Silica, amorphous is a noncombustible solid. Generally unreactive chemically. Incompatible with fluorine, oxygen difluoride, chlorine trifluoride. Soluble in molten alkalis and reacts with most metallic oxides at high temperature.

Toxicity

NIOSH: IDLH 3000 mg/m3; TWA 6 mg/m3

Silicon dioxide Use and Manufacturing

Methods of Manufacturing

Mix the aqueous solution of water glass with dilute sulfuric acid, gel at 20~30℃ under a certain pH value, use 2%~2.3% sulfuric acid solution to soak for 3~5h at 25~30℃, use 55~65 Wash at ℃ to acid content (4~6)×10. Then, remove it with a sieve and dry it to a water content of ≤10%. After screening, dry it to a water content of ≤2%.

Uses

manufacture of glass, water glass, refractories, abrasives, ceramics, enamels; decolorizing and purifying oils, petroleum products, etc.; in scouring- and grinding-compounds, ferrosilicon, molds for castings; as anticaking and defoaming agent.


IndustryApplicationRole/benefitFoodPowdered foods, such as salt, many spices, etc.Ant-caking agent/ when added to a mixture, prevents its ingredients from binding togetherNutritional health food supplementsSource of silicon/maintain healthy strong bones and joints and minimizes aluminum effects on the bodyWine, beer and juiceFining agentChemical manufactureManufacture of silicon compounds and sodium silicateRaw materialConstructionProduction of portland cementRaw materialSand castingMain ingredient/high melting pointGlassHigh purity silica glassRaw material/high temperature and corrosion resistanceDomestic glass and optical devicesEssential componentCeramicsManufacture of ceramic glazeMain constituents/forms glass when heated to bind others ingredients togetherMetallurgyManufacture of silicon alloysRaw material or additivePharmaceuticalDrug tablets makingFlow agent/aids powder flow when tablets are formedPreventing Alzheimer’s diseaseEffective components/minimizes aluminum effects on the body which may cause Alzheimer’s diseaseElectronicsFiber optic cablesRaw material/high level of heat conductivity and low rate of transmission lossWire insulationRaw material/high melting point and good insulating propertySemi-conductorsSource of siliconPiezoelectric transducerMain component/can convert mechanical energy to electrical energy and vice-versaOthersRefractory materialsMain component/high melting point and high shock resistanceRubber and plasticsAdditive/improves wearing capacityDNA ExtractionSource of silicon/has binding properties which help to isolate the strands of DNAManufacture of silica gelSource of silicon/hygroscopicpropertyDefoamingDefoamer componentSilica-based aerogelSource of siliconHydraulic fracturingThickening agent


silica is also known as silicone dioxide. Silica has a variety of applications: to control a product’s viscosity, add bulk, and reduce a formulation’s transparency. It can also function as an abrasive. In addition, it can act as a carrier for emollients, and may be used to improve a formulation’s skin feel. Spherical silica is porous and highly absorbent, with absorption capabilities roughly 1.5 times its weight. A typical claim associated with silica is oil control. It is found in sunscreens, scrubs, and wide range of other skin care, makeup, and hair care preparations. It has been successfully used in hypoallergenic and allergy-tested formulations.


Silica (SiO2) (RI: 1.48) is mined from deposits of diatomaceous soft chalk-like rock (keiselghur). This is an important group of extender pigments, which is used in a variety of particle sizes. They are used as a flatting agent to reduce gloss of clear coatings and to impart shear thinning flow properties to coatings. They are relatively expensive.


Silicon(IV) oxide, amorphous is used as carriers, processing aids, anti-caking and free-flow agents in animal feed. Defoamer applications such as paint, food, paper, textile and other industrial applications. Synthetic silicon dioxides are used as a rheology control agent in plastics. It is also used to manufacture adhesives, sealants and silicones.

Production

Commercial production of silica typically involves mining quartz-rich materials such as sandstone, quartzite, or vein quartz, followed by crushing and grinding to obtain the desired particle size. The raw material is then purified through processes like washing, flotation, or acid leaching to remove impurities such as iron, aluminium, and other trace elements.

Silica is silicon dioxide, one of the most abundant materials on the earth's crust. Quartz is an example of silica. It is used as a filler in fertilizers, and also, in the manufacture of glass, ceramics, abrasives, rubber and cosmetics.

Computed Properties

Molecular Weight:60.084
Hydrogen Bond Acceptor Count:2
Exact Mass:59.966755773
Monoisotopic Mass:59.966755773
Topological Polar Surface Area:34.1
Heavy Atom Count:3
Complexity:18.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not specified in provided sources

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • HUZHOU ZHANWANG PHARMACEUTICAL CO LTD

    United States United States
    Active
  • Evonik Specialty Chemicals(Shanghai) Co., Ltd.

    China China
    Active
  • Hubei Huifu Nanomaterial Co., Ltd.

    China China
    Active

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