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Home > Encyclopedia > Betaine hydrochloride

Betaine hydrochloride

pharmaceutical raw materials
Betaine hydrochloride structure

Betaine hydrochloride 

structure
  • CAS No:

    590-46-5

  • Formula:

    C5H12ClNO2

  • Chemical Name:

    Betaine hydrochloride

  • Synonyms:

    Betaine Hydrochloride, AR;acidolhydrochloride;Acidol-Pepsin;Acinorm;Acipepsol;Aciventral forte;aciventralforte;Ammonium, (carboxymethyl)trimethyl-, chloride

  • Categories:

    Chemical Reagents  >  Organic Reagents

Description

Betaine hydrochloride is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns.


Betaine Hydrochloride is the hydrochloride form of betaine, a crystalline alkaloid occurring in sugar beets and other plants. Betaine, acting as a transmethylating metabolic intermediate, is the oxidation product of choline. Betaine hydrochloride is used as a gastric acidifier supplement.|A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)


Betaine hydrochloride is a vitamin-like substance that is a source of hydrochloric acid and aids the production of stomach acid. Gastric acid also helps protect the gastrointestinal tract from harmful bacteria. A normal level of gastric acid in the stomach—100,000-1,000,000 times more acidic than water—is sufficient to destroy bacteria, but some people produce deficient amounts of stomach acid, a condition that may lead to bacterial and parasitic infections of the intestines.One study showed that fasting people with normal gastric acid levels in the stomach had almost no bacteria in the small in- testine, while individuals with low levels of hydrochloric acid had some bacterial colonization in the stomach.Betaine hydrochloride is therefore recommended by some medical practitioners to sustain a healthy and normal production of stomach acid, especially to those that suffer from disorders such as allergies and asthma.Betaine hydrochloride is a synthesized chemical, and is not obtained from any plant or animal source. Gastric acid is produced by stomach cells, and is not available from any food source. Occasionally, betaine (C5H11NO2 )is recommended to reduce blood levels of homocysteine, which is associated with heart disease. This form of betaine is different from betaine hydrochlo- ride, and is available only with a doctor’s prescription.


colorless to white crystals


Betaine(trimethyl glycine) is an osmoprotectant, which is highly effective than proline. It is formed in fromcholine. Betaineis usually present in grains, spinach, beets,broccoli, shellfish and marine algae.

Betaine hydrochloride Basic Attributes

153.61

153.05600

3916181

209-683-1

JK8U8K4D6K

758207|32191|3976

TSCA listed

DTXSID0044446

C82301

Colorless to white

A16AA06|A - Alimentary tract and metabolism

29239000

Characteristics

37.30000

-3.21880

colorless to white crystals

1.29[at 20℃]

241-242 °C(lit.)

64.7 g/100 mL (25 ºC)

Store in a cool, dry place. Store in a tightly closed container.

0Pa at 25℃

Not classified

1 (50g/l, H2O, 20℃)

122.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

400 °C

room temp

Safety Information

NONH for all modes of transport

3

Xi,Xn

26-39-24/25-36

BP3136000

Xi; Xn

Stable under normal temperatures and pressures.

P305 + P351 + P338

36-36/37/38-20/21/22

|Danger|H318 (47.83%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, P310, and P337+P313|Aggregated GHS information provided by 123 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Adjunctive treatment of homocystinuria, involving deficiencies or defects in:cystathionine beta-synthase (CBS);5,10-methylene-tetrahydrofolate reductase (MTHFR);cobalamin cofactor metabolism (cbl).Cystadane should be used as supplement to other therapies such as vitamin B6 (pyridoxine), vitamin B12 (cobalamin), folate and a specific diet.

Endogenous factors or drugs that increase the transport and metabolism of LIPIDS including the synthesis of LIPOPROTEINS by the LIVER and their uptake by extrahepatic tissues. (See all compounds classified as Lipotropic Agents.)|Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)

Acidin Pepsin

Betaine hydrochloride Use and Manufacturing

Methods of Manufacturing

To the reaction flask, 335 g (2 mol) of betaine methyl ester hydrochloride was added, and 350 g of water and 5 g (1.5percent) of self-developed Ti-SiO363 g (2 mol) of betaine ethyl ester hydrochloride was added to the reaction flask, and 500 g of water and 10 g (2.75percent) of theself-developed Ti-SiOTo the reaction flask was added 420 (2 mol) g of betaine butyl ester hydrochloride, and 838 g of water and 12.6 g (3percent) of self-developed Ti-SiO

Uses

1. Antiarteriosclerotic, hypolipaemic, hepatoprotectant
2. Antiprotozoal, coccidiostat
3. Betaine is used as gastric acidifier.


Betaine hydrochloride can be used as antiarteriosclerotic, hypolipaemic, hepatoprotectant.


antiprotozoal, coccidiostat


Betaine is used as gastric acidifier.naturopaths have long held that low stomach acid is a widespread problem that interferes with the digestion and absorption of nutrients. Betaine hydrochloride is one of the most common recommendations for this condi- tion. It helps make some minerals and other nutrients more absorbable, and may be especially helpful with nu- tritional supplements, which are often taken in tablets or capsules that may not be easily digested.

Methanaminium, 1-carboxy-N,N,N-trimethyl-, chloride (1:1): ACTIVE

Human drugs -> Cystadane -> EMA Drug Category|Other alimentary tract and metabolism products -> Human pharmacotherapeutic group|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:153.61
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:153.0556563
Monoisotopic Mass:153.0556563
Topological Polar Surface Area:37.3
Heavy Atom Count:9
Complexity:93.1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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