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Thifluzamide

Thifluzamide structure

CAS No:
130000-40-7
Formula:
C13H6Br2F6N2O2S
Chemical Name:
Thifluzamide
Synonyms:
5-Thiazolecarboxamide,N-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)-;N-[2,6-Dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl)-5-thiazolecarboxamide;MON 24000;Thifluzamide;Greatam;Pulsor;2′,6′-Dibromo-2-methyl-4′-trifluoromethoxy-4-trifluoromethyl-1,3-thiazole-5-carboxyanilide;1135441-69-8
Categories:
Agrochemicals > Fungicides

Description

Thifluzamide is a powerful and effective fungicide. When used safely and correctly it can be effective on rice and other crops because of improved water dispersal techniques. Thifluzamide is highly active against Basidiomycete fungi, in particular Rhizoctonia solani, primarily in rice, potatoes, and turf markets.

Thifluzamide is an aromatic amide obtained by formal condensation of the carboxy group of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid with the amino group of 2,6-dibromo-4-(trifluoromethoxy)aniline. Used to control Rhizoctonia spp. diseases on rice, potatoes, maize, grass and other crops. It has a role as an EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor and an antifungal agrochemical. It is an aromatic amide, an aromatic ether, an organofluorine compound, a member of 1,3-thiazoles, a dibromobenzene and an anilide fungicide.

Thifluzamide Basic Attributes

Molecular Weight：

528.06200

Exact Mass：

528.06

EC Number：

603-378-0

UNII：

2J3TB6Z254

DSSTox ID：

DTXSID6057954

Characteristics

PSA：

79.46000

XLogP3：

6.21920

Density：

1.93 g/cm3

Melting Point：

178 °C

Boiling Point：

375.9ºC at 760mmHg

Flash Point：

181.2ºC

Refractive Index：

1.569

Water Solubility：

3.03e-06 M

Storage Conditions：

0-6ºC

Vapor Pressure：

7.51E-06mmHg at 25°C

Safety Information

Packing level：

III

Transport codes：

UN 3077 9 / PGIII

hazard class code：

50/53

safety instructions：

60-61

Marks：

Precautionary statement(s)：

P273-P501

Hazard Statements：

H410

GHS Classification：

|Warning|H400 (99.22%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 128 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P391, P405, and P501

Drug Information

MeSH Entry Terms：

2',6'-dibromo-2-methyl-4'-trifluoromethoxy-4-trifluoromethyl-1,3-thiazole-5-carboxanilide

Thifluzamide Use and Manufacturing

It belongs to thiazole amide fungicide and has strong systemic conductivity and long-lasting effect. Thiafuramide is an inhibitor of succinate dehydrogenase. Due to its fluorine content, it is very competitive in the biochemical process, and it is not easy to recover once it is combined with a substrate or enzyme. Thiafuramide is active against pathogenic fungi such as Rhizoctonia spp., Puccinia spp., Sphaerotheca spp., Sphaerotheca spp., Fusarium spp., and Sclerotium spp., especially those caused by Basidiomycetes Diseases such as sheath blight and stand blight have special effects.

Computed Properties

Molecular Weight:528.06
XLogP3:6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:3
Exact Mass:527.84004
Monoisotopic Mass:525.84209
Topological Polar Surface Area:79.5
Heavy Atom Count:26
Complexity:512
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

4-Aminophenol

Ethyl 4,4,4-trifluoroacetoacetate

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