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Lisinopril dihydrate

Lisinopril dihydrate structure

CAS No:
83915-83-7
Formula:
C21H31N3O5.2H2O
Chemical Name:
Lisinopril dihydrate
Synonyms:
L-Proline,N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-,hydrate (1:2);L-Proline,1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-,dihydrate,(S)-;L-Proline,N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-,dihydrate;Lisinopril dihydrate
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.Target: ACELisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and sympto

Lisinopril dihydrate Basic Attributes

Molecular Weight：

405.49

EC Number：

278-488-1

HScode：

2933990090

Characteristics

PSA：

132.96000

XLogP3：

2.26430

Appearance：

white solid

Density：

1.251 g/cm3

Melting Point：

148 °C

Boiling Point：

666.4ºC at 760 mmHg

Flash Point：

356.9ºC

Refractive Index：

-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)

Water Solubility：

H2O: ≥10 mg/mL

Storage Conditions：

2-8°C

Specific rotation：

25405 -120° (c = 1 in 0.25M pH 6.4 zinc acetate); 25436 -96° (c = 1 in 0.25M pH 6.4 zinc acetate)

Safety Information

Hazard category：

IRRITANT

Transport codes：

TW3589990

wgk germany：

hazard class code：

20/21/22

safety instructions：

22-24/25-36

RTECS Number：

TW3589990

Marks：

Xi,Xn

Stability/Shelf Life：

Hygroscopic

Lisinopril dihydrate Use and Manufacturing

An orally active angiotensin-converting enzyme (ACE) inhibitor. S,S,S-Isomer of Lisinopril

Material

Magnesium sulfate heptahydrate

Triethylamine

Sodium bicarbonate

Triethylamine, hydrochloride

Trifluoroacetic acid

Polystyrene

Drug Function and Efficacy

Lisinopril is a synthetic peptide derivative and an oral long-acting angiotensin converting enzyme inhibitor. It reduces the concentration of angiotensin II (a strong vasoconstrictor) and aldosterone, leading to peripheral vasodilation and reduced vascular resistance, thereby lowering blood pressure. Research data show that the effect of long-term use of this product will not weaken, and there will be no blood pressure rebound after immediate discontinuation of the drug. In patients with congestive heart failure, lisinopril reduces the preload and afterload of the heart by dilating arteries and veins, increases cardiac output, and does not cause reflex tachycardia. This product rarely produces hypokalemia and hyperuricemia caused by thiazide drugs.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Lisinopril Capsules
Ingredients	The main ingredient of this product is lisinopril.
Indication	1. Combined use with diuretics When patients receiving this product are treated with diuretics, the antihypertensive effect is usually enhanced. For patients who have been treated with diuretics, especially those who have been treated with diuretics recently, excessive reduction in blood pressure may occur when this product is added. The possibility of symptomatic hypotension can be greatly reduced by stopping diuretics before starting treatment with this product. This product starts with a small dose and gradually adjusts the dose. 2. The antihypertensive effect is enhanced when used with other antihypertensive drugs, among which it has a greater additive effect with drugs that cause renin release or affect sympathetic activity, and a less than additive effect with beta blockers. 3. Used with potassium-retaining diuretics such as spironolactone, triamterene, and amiloride may cause hyperkalemia. 4. Non-steroidal anti-inflammatory analgesics, especially indomethacin, can inhibit prostaglandin synthesis and cause water and sodium retention. When used with this product, the antihypertensive effect of this product may be weakened.
Specifications	10mg based on C21H31N3O5
Manufacturer	Livzon (GROUP) Pharmaceutical FACTORY

Jessen Lisinopril Tablets
Specifications	10mg/tablet

Lisinopril Tablets
Ingredients	The main ingredient of this product is: lisinopril.
Indication	1. Indomethacin can weaken the antihypertensive effect of this product. 2. This product can increase blood potassium, so it should not be used in combination with potassium-retaining diuretics or potassium preparations.
Specifications	5 mg

See More Related Drugs

Registered Holders

EVONIK OPERATIONS GMBH

France
Active
GEDEON RICHTER PLC

Brazil
Active
ZHONGFU Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

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Guide of Lisinopril dihydrate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

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