 Home > Encyclopedia > Isavuconazole

Isavuconazole

Isavuconazole structure

CAS No:
241479-67-4
Formula:
C22H17F2N5OS
Chemical Name:
Isavuconazole
Synonyms:
Isaconazole;4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile;Isavucozole;4-(2-((2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile;Isavuconazonium;Isavuconazole(BAL-4815;Isavuconazole;4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Isavuconazonium, the water-soluble pro-drug of isavuconazole, is developed by Basilea Pharmaceutica. Isavuconazole, like other azoles, inhibits ergosterol synthesis and is a water-soluble compound with both oral and intravenous formulations. It has excellent bioavailability and a long elimination half-life, allowing for once-weekly dosing. It is the only broad-spectrum water-soluble triazole available.

ChEBI: Isavuconazole is a 1,3-thiazole that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,5-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively. It is an antifungal drug used for the treatment of invasive aspergillosis and invasive mucormycosis. It has a role as an ergosterol biosynthesis inhibitor, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor and an orphan drug. It is a member of 1,3-thiazoles, a nitrile, a difluorobenzene, a tertiary alcohol, a triazole antifungal drug and a conazole antifungal drug.

Isavuconazole Basic Attributes

Molecular Weight：

437.47

Exact Mass：

437.47

EC Number：

1592732-453-0

Color/Form：

Off-White to Beige

Characteristics

Density：

1.38

Melting Point：

89 - 91oC

Boiling Point：

678.0±65.0 °C(Predicted)

PKA：

11.42±0.29(Predicted)

Critical Temperature & Pressure：

2-8°C

Safety Information

wgk germany：

WGK 3

Isavuconazole Use and Manufacturing

Isavuconazole is a new triazole currently undergoing phase III clinical trials. This compound has shown in vitro activity against a large number of clinical important yeasts and molds including Aspergillus spp., Fusarium spp., Scedosporium spp., Candida spp., the Zygomycetes and Cryptococcus spp.

Recommended Suppliers of Isavuconazole

BrightGene Health Technology Co., Ltd Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of APIs,Veterinary,Cosmetic Ingredients,Peptides,intermediates,food ingredients

Isavuconazole GMP 99% White to Light Yellow Holy Pharm

CAS No.: 241479-67-4

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Isavuconazole

CAS No.: 241479-67-4

Content: 99.00%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Isavuconazole 99% see COA Kanbei kanbei

CAS No.: 241479-67-4

Grade: Industrial Grade

Content: 99%

Inquiry
NewRoute Pharma Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Avibactam Sodium,Blonanserin,Relebactam,Tofacitinib

Isavuconazole

CAS No.: 241479-67-4

Grade: Pharmaceutical Grade

Inquiry