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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine structure

CAS No:
315703-52-7
Formula:
C19H18N4OS
Chemical Name:
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
Synonyms:
N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine;Hh Signaling Antagonist VII, JK184;JK 184;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;CS-2369;JK184 (JK-184

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Basic Attributes

Molecular Weight：

350.44

Exact Mass：

350.12013238

DSSTox ID：

DTXSID70360042

Characteristics

PSA：

79.69000

XLogP3：

4.98150

Density：

1.3

Safety Information

wgk germany：

hazard class code：

22-41

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P280; P305 + P351 + P338

Hazard Statements：

H302; H318

GHS Classification：

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

JK184

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Use and Manufacturing

JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]

Computed Properties

Molecular Weight:350.4
XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:350.12013238
Monoisotopic Mass:350.12013238
Topological Polar Surface Area:79.7
Heavy Atom Count:25
Complexity:432
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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JK 184

CAS No.: 315703-52-7

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Guide of N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
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