1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
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1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
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CAS No:
84477-87-2
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Formula:
C14H17N3O2S
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Chemical Name:
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
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Synonyms:
Isoquinoline,5-[(2-methyl-1-piperazinyl)sulfonyl]-;Piperazine,1-(5-isoquinolinylsulfonyl)-2-methyl-;5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline;H 7;1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine;Protein kinase inhibitor H7
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CAS No:
Description
5-(2-methylpiperazine-1-sulfonyl)isoquinoline is a member of isoquinolines and a N-sulfonylpiperazine. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor.|A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
Characteristics
70.7 Ų
1.277±0.06 g/cm3
495.3±55.0 °C(Predicted)
LD50 intravenous in mouse: 94mg/kg
7.69±0.40
Drug Information
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Computed Properties
Molecular Weight:291.37
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:291.10414797
Monoisotopic Mass:291.10414797
Topological Polar Surface Area:70.7
Heavy Atom Count:20
Complexity:434
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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