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Altiratinib

Altiratinib structure

CAS No:
1345847-93-9
Formula:
C26H21F3N4O4
Chemical Name:
Altiratinib
Synonyms:
N-(4-(2-(cyclopropanecarboxamido)pyridin-4-yloxy)-2,5-difluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;Altiratinib(DCC2701);Altiratinib;DP 5164;DCC2701 (Altiratinib);Altiratinib(DCC-22701);Altiratinib(DCC2701,DP5164);DCC-2701
Categories:
Organic Chemistry > Amides

Description

Altiratinib is an orally bioavailable inhibitor of c-Met/hepatocyte growth factor receptor (HGFR), vascular endothelial growth factor receptor type 2 (VEGFR2), Tie2 receptor tyrosine kinase (TIE2), and tropomyosin receptor kinase (Trk), with potential antiangiogenic and antineoplastic activities. Upon administration, altiratinib selectively binds to c-Met, VEGFR2, Tie2 and Trk tyrosine kinases, which may lead to the inhibition of endothelial cell migration, proliferation and survival. This also results in both an inhibition of tumor cell proliferation and increased tumor cell death in c-Met/VEGFR2/Tie2/Trk-expressing cells. These receptor tyrosine kinases (RTKs), frequently overexpressed or mutated by a variety of tumor cell types, play crucial roles in the regulation of angiogenesis, tumor cell growth and survival.

Altiratinib Basic Attributes

Molecular Weight：

510.46

Exact Mass：

510.15148965

EC Number：

1592732-453-0

UNII：

T678746713

NCI Thesaurus Code：

C118290

Characteristics

PSA：

109.42000

XLogP3：

5.21610

Density：

1.557±0.06 g/cm3

Boiling Point：

763.5±60.0 °C(Predicted)

PKA：

12.09±0.70

Drug Information

MeSH Entry Terms：

DCC-2701

Computed Properties

Molecular Weight:510.5
XLogP3:4.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:510.15148965
Monoisotopic Mass:510.15148965
Topological Polar Surface Area:109
Heavy Atom Count:37
Complexity:863
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Altiratinib

Anqing Rongchuang Biotechnology Co., Ltd Contact Supplier

CN
1 YR

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Manufactory Supplier of SR17018

Altiratinib(DCC-22701)

Unit Price: $1967.92 /G FOB

CAS No.: 1345847-93-9

Content: 98%

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