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Bisbenzimidazole

Bisbenzimidazole structure

CAS No:
23491-44-3
Formula:
C25H24N6O
Chemical Name:
Bisbenzimidazole
Synonyms:
Phenol,4-[5-(4-methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]-;Phenol,p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2-benzimidazolyl]-;4-[5-(4-Methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]phenol;2-[2-(4-Hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazyl)benzimidazole;2-[2-(4-Hydroxyphenyl)-6-benzimidazolyl]-6-(1-methyl-4-piperazinyl)benzimidazole;Pibenzimol;Bisbenzimidazole;SL 1063;SL 11063;691353-97-6

Description

Pibenzimol is a bibenzimidazole and a N-methylpiperazine. It has a role as a fluorochrome and an anthelminthic drug.|Pibenzimol is a fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)|A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.

Bisbenzimidazole Basic Attributes

Molecular Weight：

424.5

Exact Mass：

424.50

EC Number：

245-689-0

UNII：

LHQ7J5KV9B

DSSTox ID：

DTXSID3066899

NCI Thesaurus Code：

C546

Characteristics

PSA：

84.1 Å²

Density：

1.355±0.06 g/cm3

Melting Point：

>300 °C

Boiling Point：

746.9±70.0 °C(Predicted)

PKA：

9.23±0.15

Safety Information

wgk germany：

hazard class code：

22-36/38

safety instructions：

26-36

RTECS Number：

SM1140500

Marks：

Drug Information

MeSH：

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)|Pharmacological agents destructive to nematodes in the superfamily Filarioidea. (See all compounds classified as Filaricides.)

MeSH Entry Terms：

4-(5-(4-Methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)phenol, trihydrochloride

Bisbenzimidazole Use and Manufacturing

Manufacturing Info：

Phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-: INACTIVE

Computed Properties

Molecular Weight:424.5
XLogP3:4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:424.20115941
Monoisotopic Mass:424.20115941
Topological Polar Surface Area:84.1
Heavy Atom Count:32
Complexity:634
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Bisbenzimidazole

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties

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