Temelastine
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Temelastine
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CAS No:
86181-42-2
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Formula:
C21H24BrN5O
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Chemical Name:
Temelastine
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Synonyms:
4(1H)-Pyrimidinone,2-[[4-(5-bromo-3-methyl-2-pyridinyl)butyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-;2-[[4-(5-Bromo-3-methyl-2-pyridinyl)butyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-4(1H)-pyrimidinone;SKF 93944;Temelastine
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CAS No:
Drug Information
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)
SK and F 93944
Computed Properties
Molecular Weight:442.4
XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:441.11642
Monoisotopic Mass:441.11642
Topological Polar Surface Area:79.3
Heavy Atom Count:28
Complexity:593
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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