7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
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7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
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CAS No:
30195-30-3
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Formula:
C13H10ClN3O
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Chemical Name:
7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
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Synonyms:
2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-;2H-1,4-Benzodiazepin-2-one,7-chloro-1,3-dihydro-5-pyrrol-2-yl-;7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one;Ro 5-3335;NSC 66020;153374-31-3
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CAS No:
Description
Ro 5-3335 is a 1,4-benzodiazepinone that is nordazepam in which the phenyl substituent has been replaced by a 1H-pyrrol-2-yl group. It inhibits gene expression in HIV-1 at the transcriptional level through interference with Tat-mediated transactivation. It has a role as an antineoplastic agent, an anti-HIV-1 agent, a RUNX1 inhibitor and a HIV-1 Tat inhibitor. It is a 1,4-benzodiazepinone, an organochlorine compound and a member of pyrroles.
7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one Basic Attributes
259.69 g/mol
259.69
DLH4T68L7I
66020
DTXSID20184270
Computed Properties
Molecular Weight:259.69
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:259.0512396
Monoisotopic Mass:259.0512396
Topological Polar Surface Area:57.2
Heavy Atom Count:18
Complexity:371
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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