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Ramosetron

Ramosetron structure

CAS No:
132036-88-5
Formula:
C17H17N3O
Chemical Name:
Ramosetron
Synonyms:
Methanone,(1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-;Methanone,(1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-,(R)-;Methanone,(1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-;(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]methanone;Ramosetron;(-)-(R)-1-Methylindol-3-yl 4,5,6,7-tetrahydro-5-benzimidazolylketone;Nor-YM 060;Nasea;794495-45-7
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Ramosetron is a member of indoles.|Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.

Ramosetron Basic Attributes

Molecular Weight：

279.34 g/mol

Exact Mass：

279.34

UNII：

7ZRO0SC54Y

DSSTox ID：

DTXSID0043842

Characteristics

PSA：

50.7 Å²

Drug Information

Drug Indication：

For the treatment of nausea and vomiting and diarrhea-predominant irritable bowel syndrome in males.

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)|Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)

MeSH Entry Terms：

5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1H-benzimidazol

Computed Properties

Molecular Weight:279.34
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:279.137162174
Monoisotopic Mass:279.137162174
Topological Polar Surface Area:50.7
Heavy Atom Count:21
Complexity:413
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes