meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane
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meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane
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CAS No:
21416-88-6
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Formula:
C12H18N4O4
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Chemical Name:
meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane
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Synonyms:
2,6-Piperazinedione,4,4′-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-,rel-;2,6-Piperazinedione,4,4′-(1,2-dimethylethylene)di-,meso-;2,6-Piperazinedione,4,4′-(1,2-dimethyl-1,2-ethanediyl)bis-,(R*,S*)-;rel-4,4′-[(1R,2S)-1,2-Dimethyl-1,2-ethanediyl]bis[2,6-piperazinedione];meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane;ICRF 193;meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane;ICFR 193
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CAS No:
Description
ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent.
Safety Information
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P310, P302+P352, P321, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)
4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione
Computed Properties
Molecular Weight:282.30
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:282.13280507
Monoisotopic Mass:282.13280507
Topological Polar Surface Area:98.8
Heavy Atom Count:20
Complexity:390
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- ear eczema
- calcium phosphide
- fe3o4
- azoxystrobin
- cabr2
- combi blocks
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