L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
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L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
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CAS No:
39386-80-6
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Formula:
C41H62N12O11
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Chemical Name:
L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
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Synonyms:
Ang I (1-7);angiotensin (1-7);angiotensin 1-7;angiotensin I (1-7);angiotensin II (1-7);angiotensin II (1-7) heptapeptide;angiotensin II-(1-7);angiotensin-(1-7);angiotensin-I (1-7);TXA-127;TXA127;Angiotensin (1-7);angiotensin 1-7;51833-78-4;TXA127;Angiotensin i (1-7);Angiotensin II (1-7) heptapeptide;angiotensin-(1-7);angiotensin II (1-7);ASP-ARG-VAL-TYR-ILE-HIS-PRO;8-Des-phe-angiotensin II;UNII-IJ3FUK8MOF;TXA-127;IJ3FUK8MOF;Angiotensin, Canine, Rat;Angiotensin I/II (1-7);CHEBI:55438;Ile(5)-angiotensin II (1-7);MFCD00153513;Ang-(1-7);39386-80-6;L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline;L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline;Human angiotensin-(1-7);1-7-Human angiotensin II;Angiotensin II, des-phe(8)-;TXA 127;Angiotensin(1-7);C41H62N12O11;AngiotensinI(1-7);Angiotensin II, des-phenylalanine(8)-;Angiotensin, canine, ra;ang 1-7;GTPL582;Ang(1-7);Angiotensin II, 5-L-isoleucine-8-de-L-phenylalanine-;GTPL5578;[Ile5]Angiotensin I (1-7);CHEMBL3545347;SCHEMBL15926158;BDBM85556;[125I]ang-(1-7);TXA127; Ang-(1-7);3446AH;ZINC96077632;AKOS024456667;CS-3413;DB11720;Angiotensin (1-7) acetate salt hydrate;Angiotensin II, 8-de-L-phenylalanine-;NCGC00167219-01;HY-12403;C15850;[125I]angiotensin-(1-7) (human, mouse, rat);833A784;Angiotensin I/II fragment 1-7 trifluoroacetate salt;Q27074464;H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid;(S)-1-((6S,9S,12S,15S,18S)-18-((1H-imidazol-4-yl)methyl)-1-amino-6-((S)-2-amino-3-carboxypropanamido)-15-sec-butyl-12-(4-hydroxybenzyl)-1-imino-9-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecane)pyrrolidine-2-carboxylic acid
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CAS No:
Description
Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.|TXA127 has been investigated for the treatment of Miscellaneous Peripheral Blood Cell Abnormalities.|Therapeutic Angiotensin-(1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II.
L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline Basic Attributes
899.0 g/mol
898.46610084 g/mol
IJ3FUK8MOF
C68962
Drug Information
Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
Ang I (1-7)
L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline Use and Manufacturing
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:899.0
XLogP3:-3
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:25
Exact Mass:898.46610084
Monoisotopic Mass:898.46610084
Topological Polar Surface Area:380
Heavy Atom Count:64
Complexity:1660
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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