6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine
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6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine
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CAS No:
113494-35-2
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Formula:
C12H12FN5O2
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Chemical Name:
6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine
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Synonyms:
2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine;4'-fluoro-3'-nitropyrimethamine;4-FNPM;113494-35-2;4'-Fluoro-3'-nitropyrimethamine;6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine;UNII-7WQ46TDS01;7WQ46TDS01;4-Fnpm;ACMC-1BOJ3;2,4-Diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine;DTXSID30150421;2,4-Pyrimidinediamine,6-ethyl-5-(4-fluoro-3-nitrophenyl)-;5-(3-Nitro-4-fluorophenyl)-6-ethylpyrimidine-2,4-diamine;2,4-diamino-5-(4'-fluoro-3'-nitrophenyl)-6-ethylpyrimidine
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CAS No:
6-ethyl-5-(4-fluoro-3-nitrophenyl)pyrimidine-2,4-diamine Basic Attributes
277.25 g/mol
277.09750280 g/mol
7WQ46TDS01
DTXSID30150421
Drug Information
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Folic Acid Antagonists.)
2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine
Computed Properties
Molecular Weight:277.25
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:277.09750280
Monoisotopic Mass:277.09750280
Topological Polar Surface Area:124
Heavy Atom Count:20
Complexity:353
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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