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AB 1010 Mesylate

AB 1010 Mesylate structure

CAS No:
1048007-93-7
Formula:
C29H34N6O4S2
Chemical Name:
AB 1010 Mesylate
Synonyms:
AB 1010 Mesylate;AB1010 Mesylate;AB-1010 Mesylate;Masitinib (Mesylate);Masivet Mesylate;Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-,methanesulfonate;AB1010 MESYLATE; MASIVET MESYLATE; AB-1010 MESYLATE; AB 1010 MESYLATE;Masitinib mesylate (AB1010 mesylate

Description

Masitinib Mesylate is the orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).

AB 1010 Mesylate Basic Attributes

Molecular Weight：

594.74806

Exact Mass：

594.20829593

UNII：

ZK89EG3A18

DSSTox ID：

DTXSID70146747

NCI Thesaurus Code：

C79831

Color/Form：

White to yellow

ATC Code：

L01XE22|QL01XE90

Characteristics

Critical Temperature & Pressure：

Store at -20°C

Safety Information

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

Drug Indication：

Treatment of amyotrophic lateral sclerosis.|Treatment of mastocytosis|Treatment of non-resectable dog mast-cell tumours (grade 2 or 3) with confirmed mutated c-KIT tyrosine-kinase receptor.|Treatment of gastro-intestinal stromal tumours|Treatment of amyotrophic lateral sclerosis

MeSH Entry Terms：

4-((4-methylpiperazin-1-yl)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide

AB 1010 Mesylate Use and Manufacturing

Uses

Masitinib Mesylate can be used to treat sickle cell disease.

Masitinib is a novel tyrosine kinases inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, resectively.

Use Classification：

Human drugs -> Orphan -> Alsitek -> EMA Drug Category|Antineoplastic agents -> Human pharmacotherapeutic group|Human drugs -> Orphan -> Masipro -> EMA Drug Category|Veterinary drugs -> Masivet -> EMA Drug Category|Antineoplastic agents -> Veterinary pharmacotherapeutic group|Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans

Recommended Suppliers of AB 1010 Mesylate

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Masitinib mesylate

CAS No.: 1048007-93-7

Content: 99.00%

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Guide of AB 1010 Mesylate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Recommended Suppliers
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