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5-Amino-2-methoxypyridine

5-Amino-2-methoxypyridine structure

CAS No:
6628-77-9
Formula:
C6H8N2O
Chemical Name:
5-Amino-2-methoxypyridine
Synonyms:
3-Pyridinamine,6-methoxy-;Pyridine,5-amino-2-methoxy-;6-Methoxy-3-pyridinamine;5-Amino-2-methoxypyridine;3-Amino-6-methoxypyridine;2-Methoxy-5-aminopyridine;6-Methoxy-3-pyridinylamine;NSC 59708;6-Methoxy-3-aminopyridine;(2-Methoxypyridin-5-yl)amine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

yellow-brown or red to very dark red liquid

5-Amino-2-methoxypyridine Basic Attributes

Molecular Weight：

124.14

Exact Mass：

124.14

EC Number：

229-612-8

UNII：

ATT39K5F0C

NSC Number：

59708

DSSTox ID：

DTXSID20216484

HScode：

2933399090

Characteristics

PSA：

48.1

XLogP3：

Appearance：

Yellow-brown or red to very dark red Liquid

Density：

1.575

Melting Point：

30 °C

Boiling Point：

125-126 °C @ Press: 10 Torr

Flash Point：

>230 °F

Refractive Index：

n20/D 1.575(lit.)

Water Solubility：

Slightly soluble

Storage Conditions：

2-8°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

US1836000

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-37/39-36

RTECS Number：

US1836000

Marks：

Xn,Xi

Hazard note：

Irritant

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-Amino-2-methoxypyridine Use and Manufacturing

Methods of Manufacturing

In methanol was added to the reactor sequentially 67.28g, 2- methoxy-5-nitropyridine 16.82g (0.1mol), 10percent Pd / C0.50g, hydrogen-to 0.01MP, 62 1.5 hours, the reaction solution cooling to room temperature, filtered, recovered 10percent Pd / C next applied, the filtrate under reduced pressure to recover the solvent, the residue was extracted dichloroethane were added 75g twice, the extract was washed once with purified water, evaporated under reduced pressure dichloro after the ethane to give a slightly yellow oily liquid 2-methoxy-5-aminopyridine 11.69g, HPLC purity of 97.63percent, the yield was 92.03percent.A mixture of 2-methoxy-5-nitropyridine (5.0 g, 32.4 mmol) in HOAc (50 ml) was added iron powder (5 g, 89.53 mmol). After the mixture was heated to 60°C for 2h, the mixture was filtered through celite, and the filtered cake was washed with HOAc and then water. The filtrate was concentrate and the residue was neutralized with saturated NaHC0[0238] A mixture of 2-methoxy-5-nitropyridine (5.0 g, 32.4 mmol) in HOAc (50 ml) was added iron powder (5 g, 89.53 mmol). After the mixture was heated to 60° C. for 2 h, the mixture was filtered through celite, and the filtered cakewas washed with HOAc and then water. The filtrate wasconcentrate and the residue was neutralized with saturatedNaHC03 solution, the aqueous phase was extracted withDCM (1 00 ml), and insoluble materials were removed byfiltration. After the aqueous phase was extracted with DCM(100 mlx4), the combined organic phase was washed withbrine and concentrated to afford crude product, which waspurified by silica gel colunm chromatography (2percent MeOH inDCM) to afford compound 22 (3.5 g, yield 86percent) as a brownoil[0239] m/z: [M+Ht 125.2

Uses

Used as pharmaceutical intermediate

Computed Properties

Molecular Weight:124.14
XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:124.063662883
Monoisotopic Mass:124.063662883
Topological Polar Surface Area:48.1
Heavy Atom Count:9
Complexity:87.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethanol

Sodium sulfite

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CAS No.: 6628-77-9

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CAS No.: 6628-77-9

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Guide of 5-Amino-2-methoxypyridine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
Latest News
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5-Amino-2-methoxypyridine

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