2-Chloropropane

78.54

78.54

1730782

209-187-5

VU39J8AJ2N

2356

DTXSID6047739

COLORLESS LIQUID

29031980

0

1.90

2-chloropropane appears as a colorless liquid with a chloroform-like odor. Vapors heavier than air. Less dense than water. May irritate skin and eyes, and be narcotic in high concentrations. A fire and explosion risk. Used to make other chemicals.

0.8617 g/cm³ @ Temp: 20 °C

-117.2 °C

35.7 °C

−31 °F

1.379

H2O: 3.1 g/L (20 ºC);alcohol: miscible(lit.)

2-8°C

28.11 psi ( 55 °C)

2.7 (AIR= 1)

Oral-Rat  LD50 5000 mg/kg; Oral-Mouse LD50: 1300 mg/kg

Flammable; decomposition by heating or combustion products contain toxic chloride gas

2.8-10.7%(V)

9.20e-13 cm3/molecule*sec

CONVERSION FACTORS: 1 MG/L= APPROX 311 PPM, 1 PPM= APPROX 3.21 MG/CU M @ 25 °C, 760 MM HG|Liquid Molar Volume = 0.091726 cu m/kmol; IG Heat of Formation = -1.4477X10+8 J/kmol

Highly flammable. Slightly soluble in water.

Halogenated Organic Compounds

Highly Flammable

Halogenated aliphatic compounds, such as 2-CHLOROPROPANE, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

1099 °F (NTP, 1992)|1100 °F (593 °C)

Standard state = -482.0 kcal/mol at 25 °C, as a liquid

6.42 kcal/mol at 25 °C

Critical temperature = 212 °C; Critical pressure = 46.6 atm

I

3

UN 2456 3/PG 1

3

12-36/37-20/21/22-11-40

9-29-36-26-16

UC7200000

F+,Xi,Xn,F

Treasury is ventilated, low temperature and dry; stored and transported separately from oxidants and acids

Heated. Open flames can explode; mix with air to form explosive mixture

Stable. Incompatible with strong oxidizing agents, strong bases. Highly flammable - note low flash point. Cool to zero C before opening.

P210-P261-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312-P403 + P235

H224-H290-H302 + H312 + H332

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Flammable - 4th degree

|Danger|H225 (97.09%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P312, P322, P330, P363, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 172 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P312, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: When working with this chemical, wear a NIOSH-approved full face chemical cartridge respirator equipped with the appropriate organic vapor cartridges. If that is not available, a half face respirator similarly equipped plus airtight goggles can be substituted. However, please note that half face respirators provide a substantially lower level of protection than do full face respirators. RECOMMENDED GLOVE MATERIALS: Permeation data indicate that butyl rubber gloves may provide protection to contact with this compound. Butyl rubber over latex gloves is recommended. However, if this chemical makes direct contact with your gloves, or if a tear, hole or puncture develops, remove them at once. (NTP, 1992)|Personnel protection: ... Wear positive pressure self-contained breathing apparatus. ... Wear appropriate chemical protective gloves, boots, and goggles.

HIGHLY FLAMMABLE

2.8%-10.7% (IN AIR)

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Use "alcohol" foam, dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Do not extinguish fire unless flow can be stopped. Apply water from as far a distance as possible. Keep run-off water out of sewers and water sources.|Evacuation: If fire becomes uncontrollable or container is exposed to direct flame -- consider evaucation of one-third (1/3) mile radius.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to knock-down vapors.|Personnel protection: Avoid breathing vapors. Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amount of water or soap and water. If contact with the material anticipated, wear appropriate chemical protective clothing.|Evacuation: If material leaking (not on fire) consider evacuation from downwind area based on amount of material spilled, location and weather conditions.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for 2-CHLOROPROPANE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily.| 0 - Materials that in themselves are normally stable, even under fire conditions.

Landfill leachate which had been treated with chlorine contained 2-chloropropane at unreported concentrations(1).

moderately toxic

2-Chloropropane's production and use as a solvent and chemical intermediate(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 53(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that 2-chloropropane will have high mobility in soil(SRC). Hydrolysis in moist soils may occur(SRC) with a measured half-life of 38 days in aqueous solution at pH 7 and 25 °C(4). Volatilization of 2-chloropropane should be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 1.8X10-2 atm-cu m/mole(SRC), calculated from experimental values for water solubility(2) and vapor pressure(5). Volatilization from dry soil surfaces(SRC) is expected based on a measured vapor pressure of 515.3 mm Hg(5).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 53(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that 2-chloropropane should not adsorb to suspended solids and sediment in water(SRC). Hydrolysis is expected to occur with a measured half-life of 38 days in aqueous solution at pH 7 and 25 °C(3). 2-Chloropropane should volatilize from water surfaces(1,SRC) based on an estimated Henry's Law constant of 1.8X10-2 atm-cu m/mole(SRC), calculated from experimental values for water solubility(2) and vapor pressure(4). Estimated half-lives for a model river and model lake are 3 hours and 4 days, respectively(1,SRC). According to a classification scheme(5), an estimated BCF value of 16(1,SRC), from a measured log Kow(6), suggests that bioconcentration in aquatic organisms is low(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-chloropropane, which has a measured vapor pressure of 515.3 mm Hg at 25 °C(2), will exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-chloropropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 17 days(3,SRC).

The rate constant for the vapor-phase reaction of 2-chloropropane with photochemically-produced hydroxyl radicals has been measured as 0.92X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 17 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A hydrolysis rate constant of 2.12X10-7/sec was measured for 2-chloropropane at pH 7 and 25 °C; this corresponds to a half-life of 38 days under these conditions(2).

An estimated BCF value of 16 was calculated for 2-chloropropane(SRC), using a measured log Kow of 1.90(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of 2-chloropropane is estimated as approximately 53(SRC), using a measured water solubility of 3050 mg/l(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that 2-chloropropane has high mobility in soil(SRC).

The Henry's Law constant for 2-chloropropane is estimated as 1.8X10-2 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 515.3 mm Hg(1), and water solubility, 3050 mg/l(2). This value indicates that 2-chloropropane will volatilize rapidly from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 3 hours(3,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 4 days(3,SRC). 2-Chloropropane's values for vapor pressure(1) and Henry's Law constant(1,2,SRC) indicate that volatilization from dry and moist soil surfaces should occur(SRC).

2-Chloropropane was isolated from Idaho Russet Burbank baked potatoes and identified as a volatile flavor component(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 145 workers (3 of these are female) are potentially exposed to 2-chloropropane in the USA(1). The general population will be exposed to 2-chloropropane via inhalation of ambient air, ingestion of food, and dermal contact with vapors, food and other products containing 2-chloropropane. Occupational exposure may be through inhalation and dermal contact at workplaces where 2-chloropropane is produced or used(SRC).

... 2-Chloropropane wan enzymatically dechlorinated in vitro by rat liver microsomes.

ACUTE/CHRONIC HAZARDS: Fire hazard: Highly dangerous; when exposed to heat, flame or oxidizers. Explosion hazard: Moderate when exposed to heat or flame. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Petrochemical manufacturing|Propane, 2-chloro-: ACTIVE

AREAL Method 1P-1B. Determination of Volatile Organic Compounds (VOCs) in Indoor Air using Solid Absorbent Tubes. Analysis by capillary GC/MS. Detection Limit = 3.4 ng.

Fire Hazards -> Flammable - 4th degree