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Prostaglandin E1

Prostaglandin E1 structure

CAS No:
745-65-3
Formula:
C20H34O5
Chemical Name:
Prostaglandin E1
Synonyms:
Prost-13-en-1-oic acid,11,15-dihydroxy-9-oxo-,(11α,13E,15S)-;Cyclopentaneheptanoic acid,3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-,(-)-;Cyclopentaneheptanoic acid,3α-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-;(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid;PGE1;Prostaglandin E1;11α,15(S)-Dihydroxy-9-oxo-13-trans-prostenoic acid;(-)-Prostaglandin E1;l-Prostaglandin E1;11α,15α-Dihydroxy-9-oxo-13-trans-prostenoic acid;Alprostadil;U 10136;Prostandin;l-PGE1;Prostandin 500;Caverject;Alprox TD;Palux;ONO 1608;Lipoprost;Topiglan;SEPA-PGE1;SEPA-alprostadil;SEPA-prostaglandin E1;Minprog;Prostivas;Prostin VR Pediatric;Liple;NSC 165559;Caveject;Vasaprostan;Liprostin;Eglandin;Lipo PGE1;Alprostan;50-83-9;22299-37-2;50865-30-0
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

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Description

Prostaglandin E1 (PGE1) is a potent vasodilator and activates the prostaglandin E1 (EP) receptor.

Prostaglandin E1 Basic Attributes

Molecular Weight：

354.48

Exact Mass：

354.48

EC Number：

212-017-2

HScode：

29375000

Characteristics

PSA：

94.8

XLogP3：

3.2

Appearance：

White to off-white powder

Density：

1.1±0.1 g/cm3

Melting Point：

115-116 °C

Boiling Point：

529.282°C at 760 mmHg

Flash Point：

288.0±26.6 °C

Refractive Index：

1.546

Water Solubility：

H2O: insoluble ;ethanol: 1 mg/mL

Storage Conditions：

−20°C

Specific rotation：

-64 º (c=1.0, C2H5OH)

PKA：

4.85(at 25 °C)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

22-36/37/38-61

safety instructions：

36-26

RTECS Number：

GY4569800

Marks：

Xn,Xi

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P281-P301 + P310

Hazard Statements：

H301-H361

Prostaglandin E1 Use and Manufacturing

Vasodilator;Prostaglandin receptoragonist

Material

Hydrogen

Drug Function and Efficacy

The intravenous alprostadil preparation with lipid microspheres as drug carriers is not easy to inactivate alprostadil due to the encapsulation of lipid microspheres. It has the targeted property of being easily distributed to damaged blood vessels, thereby playing the role of dilating blood vessels and inhibiting platelet aggregation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Alprostadil for injection
Ingredients	Chemical name: (1R, 2R, 3R)-3-hydroxy-2[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentaneheptanoic acid
Indication	This product can increase the effects of antihypertensive drugs and platelet aggregation inhibitors.
Specifications	100 μg
Manufacturer	EMeiShan Tonghui Pharmaceutical Co., Ltd.

Alprostadil Injection
Ingredients	Prostaglandin E1. Excipients: refined soybean oil, refined lecithin, concentrated glycerol, oleic acid, sodium hydroxide, water for injection.
Indication	Avoid mixing with plasma expanders (dextran, gelatin preparations, etc.).
Specifications	2 ml: 10 μg
Manufacturer	Penglai Nuokang Pharmaceutical Co., Ltd.

Alprostadil for injection
Ingredients	Chemical name: (1R, 2R, 3R)-3-hydroxy-2[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentaneheptanoic acid
Indication	This product can increase the effects of antihypertensive drugs and platelet aggregation inhibitors.
Specifications	100 μg

See More Related Drugs

Registered Holders

TIEN (TIANJIN) PHARMACEUTICAL CO LTD

United States
Active
CAYMAN PHARMA SRO

United States
Active
EVERLIGHT CHEMICAL INDUSTRIAL CORP

United States
Active

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