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Trifluperidol

Trifluperidol structure

CAS No:
749-13-3
Formula:
C22H23F4NO2
Chemical Name:
Trifluperidol
Synonyms:
1-Butanone,1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-;Butyrophenone,4′-fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m-tolyl)piperidino]-;1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-1-butanone;McN-JR 2498;4′-Fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m-tolyl)piperidino]butyrophenone;Trifluperidol;Triperidol;p-Fluoro-γ-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]butyrophenone;Trisedil;Psicoperidol;Trifluoperidol;P 459;R 2498;Trifluperol;Flumoperone;NSC 170978;47612-25-9
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Trifluperidol is an aromatic ketone.|A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in the treatment of PSYCHOSES including MANIA and SCHIZOPHRENIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p621)

Trifluperidol Basic Attributes

Molecular Weight：

409.4171328

Exact Mass：

409.42

EC Number：

218-170-1

UNII：

R8869Q7R8I

NSC Number：

170978

DSSTox ID：

DTXSID4023703

ATC Code：

N - Nervous system

Characteristics

PSA：

40.5

XLogP3：

4.72890

Density：

1.26g/cm3

Boiling Point：

535.7ºC at 760 mmHg

Flash Point：

277.8ºC

Refractive Index：

1.534

Safety Information

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Trifluperidol

Trifluperidol Use and Manufacturing

Uses

Antipsychotic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:409.4
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:409.16649162
Monoisotopic Mass:409.16649162
Topological Polar Surface Area:40.5
Heavy Atom Count:29
Complexity:537
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes