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Oxytetracycline

Oxytetracycline structure

CAS No:
79-57-2
Formula:
C22H24N2O9
Chemical Name:
Oxytetracycline
Synonyms:
2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,(4S,4aR,5S,5aR,6S,12aS)-;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-;2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,[4S-(4α,4aα,5α,5aα,6β,12aα)]-;(4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide;Biostat PA;5-Hydroxytetracycline;OTC;Oxymykoin;Oxyterracyne;Oxytetracycline;Riomitsin;Ryomycin;Terrafungine;Oxytetracycline amphoteric;Terramycin;Tetran;Oxyterracine;Oxitetracyclin;Oxyterracin;Vendarcin;Macocyn;Oxytetracyclin;Oxy-Kesso-Tetra;Adamycin;Proteroxyna;Berkmycen;NSC 9169;Solkaciclina;Oksisyklin;Stevacin;Fanterrin;Oxymycin;Geomycin (Streptomyces vimosus);Lenocycline;Oxypam;Liquamycin;Dabicycline;OTC (antibiotic);Teravit;Ursocycline;Liquamycin LA 200;Tarosin;Tarocyn;Ursocyclin;Geomycin;Antibiotic TM 25;Terramycin Q 50;Mycoshield TMQTHC 20;LA 200;Geotilin;TM 50;Oxyject LA;Stecsolin;Clinimycin;OXTC;Oxydon;Oxatets;Imperacin;Unimycin;Terralon LA;Stevasin;Abbocin;Oxytetral;Oxycline;Oxiter 200;Oxylim;Oxymed 50;Oxysentin 100;Erfamycin;1405-95-4;21645-09-0;52214-46-7;96310-42-8;102287-29-6;103351-03-7;105145-10-6;106216-57-3;856305-69-6;909261-39-8;1135442-00-0;1256964-22-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Oxytetracycline is a tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions.Target: AntibacterialOxytetracycline was the second of the broad-spectrum tetracycline group of antibiotics to be discovered. Oxytetracycline works by interfering with the ability of bacteria to produce essential proteins. Without these proteins, the bacteria cannot grow, multiply and increase in numbers. Oxytetracycline therefore stops the spread

Oxytetracycline Basic Attributes

Molecular Weight：

460.43

Exact Mass：

460.43

EC Number：

201-212-8

HScode：

30029090

Characteristics

PSA：

202

XLogP3：

-1.6

Appearance：

Beige to light yellow Crystalline Powder

Density：

1.634 g/cm³ @ Temp: 20 °C

Melting Point：

184-185 °C

Boiling Point：

817.08°C at 760 mmHg

Flash Point：

394.0±32.9 °C

Refractive Index：

1.762

Water Solubility：

H2O: 0.2 g/L;Sparingly soluble in aqueous solution at 0.6 mg/mL

Storage Conditions：

-20°C

Vapor Pressure：

9.7X10-25 mm Hg at 25 deg C (est)

Toxicity：

Oral-Rat LD50: 4800 mg/kg; Oral-Mouse LD50: 2240 mg/kg

Flammability characteristics：

Combustible, the fire emits nitrogen oxides and spicy irritating smoke

Specific rotation：

-223 º (c=1 0.03N HCl)

PKA：

3.27(at 25 °C)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

63-36-36/37/38

safety instructions：

22-24/25-36/37/39-26-36

RTECS Number：

QI7875000

Marks：

Xn,Xi

Storage features：

Warehouse low temperature, ventilated, dry

Stability/Shelf Life：

DETERIORATES IN SOLN WITH PH BELOW 2, & IS RAPIDLY DESTROYED BY ALKALI HYDROXIDES. /OXYTETRACYCLINE DIHYDRATE/

Precautionary statement(s)：

P201, P202, P260, P263, P264, P270, P273, P280, P281, P305+P351+P338, P308+P313, P337+P313, P391, P405, P501

Hazard Statements：

H319

Toxicity

Toxicity class：

moderately toxic

Oxytetracycline Use and Manufacturing

Methods of Manufacturing

It is produced by fermentation of Streptomyces rimosus, calcium carbonate is added to the fermentation broth, and the solid is obtained by filtration and drying.

Uses

Oxytetracycline (terramycin) is a linear, tetracyclic broad spectrum antibiotic originally isolated from Streptomyces rimosus in 1949. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis. Oxytetracycline, although less coloured than other tetracyclines, is still a pigment and is thus sensitive to environmental and storage conditions. Commercial oxytetracycline may contain significant levels of degradation products.

Computed Properties

Molecular Weight:460.4
XLogP3:-1.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:2
Exact Mass:460.14818035
Monoisotopic Mass:460.14818035
Topological Polar Surface Area:202
Heavy Atom Count:33
Complexity:1000
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Oxalic acid

Calcium carbonate

Starch

Downstream Products

Oxytetracycline hydrochloride

Drug Function and Efficacy

Tetracycline antibiotics. This product is a broad-spectrum antibacterial agent. Many Rickettsia, Mycoplasma, Chlamydia, and Spirochete are sensitive to this product. Enterococci are resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia, etc. are also sensitive to this product. Due to the widespread use of oxytetracycline and tetracyclines over the years, common clinical pathogens have serious resistance to oxytetracycline, including Gram-positive bacteria such as Staphylococcus and most Gram-negative bacteria. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of the 30S subunit of the bacterial ribosome, inhibit the growth of the peptide chain and affect the synthesis of bacterial proteins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Oxytetracycline Tablets
Ingredients	The main ingredient of this product is oxytetracycline, and its chemical name is: 6-methyl-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide.
Indication	1 When used with antacids such as sodium bicarbonate, the absorption of this product may be reduced and its activity may be reduced due to the increase in gastric pH. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2 Drugs containing metal ions such as calcium, magnesium, and iron may form insoluble complexes with this product, reducing the absorption of this product after oral administration. 3 When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity may be enhanced. 4 When used in combination with strong diuretics such as furosemide, renal damage may be aggravated. 5 When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage may be aggravated. 6 The lipid-lowering drugs colestyramine or colestipol may affect the absorption of this product.
Specifications	0.25g (200,000 units)
Manufacturer	Shanxi Zhenglai Pharmaceutical Co., Ltd.

Oxytetracycline Tablets
Ingredients	The main ingredient of this product is oxytetracycline, and its chemical name is: 6-methyl-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide.
Indication	1 When used with antacids such as sodium bicarbonate, the absorption of this product may be reduced and its activity may be reduced due to the increase in gastric pH. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2 Drugs containing metal ions such as calcium, magnesium, and iron may form insoluble complexes with this product, reducing the absorption of this product after oral administration. 3 When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity may be enhanced. 4 When used in combination with strong diuretics such as furosemide, renal damage may be aggravated. 5 When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage may be aggravated. 6 The lipid-lowering drugs colestyramine or colestipol may affect the absorption of this product.
Specifications	0.25g (250,000 units)
Manufacturer	Shanxi Taihang Pharmaceutical Co., Ltd.

Oxytetracycline Tablets
Ingredients	The main ingredient of this product is oxytetracycline, and its chemical name is: 6-methyl-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide.
Indication	1 When used with antacids such as sodium bicarbonate, the absorption of this product may be reduced and its activity may be reduced due to the increase in gastric pH. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2 Drugs containing metal ions such as calcium, magnesium, and iron may form insoluble complexes with this product, reducing the absorption of this product after oral administration. 3 When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity may be enhanced. 4 When used in combination with strong diuretics such as furosemide, renal damage may be aggravated. 5 When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage may be aggravated. 6 The lipid-lowering drugs colestyramine or colestipol may affect the absorption of this product.
Specifications	0.25g (250,000 units)
Manufacturer	Shanxi Lifeng Huarui Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

HUASHU PHARMACEUTICAL CORP

United States
Active
Huashu Shanhe Pharmaceutical Co., Ltd.

China
Active
Shaanxi Xiyue Pharmaceutical (Fufeng) Co., Ltd.

China
Active

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