Propyne

40.06390

40.06

200-828-4

086L40ET1B

0560

3161|2850|1954

DTXSID0026387

Colorless gas [Note: Shipped as a liquefied compressed gas].

2901299090

0

0.63950

1-propyne appears as a colorless liquefied gas with a sweet odor. mp: -104°C, bp: -23.1°C. Insoluble in water, soluble in ethanol, chloroform and benzene. Moderately toxic by inhalation. Used as a specialty fuel. Denser than air. Vapors may ignite at distant sources of ignition and flash back.

0.7062 g/cm³ @ Temp: -50 °C

-102.7 °C

-23.2 °C @ Press: 760 Torr

-51 °C

1.363

3,640 mg/L at 20 °C (quoted, Verschueren, 1983)

Fireproof. Cool.

204.6 mm Hg ( −49.5 °C)

1.41

Flammable Gas

Explosive limits , vol% in air: 2.4-11.7

Sweet odor

5.90e-12 cm3/molecule*sec

Henry's Law constant = 1.10X10-2 atm-cu m/mol at 25 °C (est)

Specific vol = 9.7 cu ft/lb at 70 °F|Heat of formation = 185.6 kJ/mol|Heat capacity = 67.6 J/mol-deg K at 25 °C|Heat conductivity: Gas at 1 atm, 298 deg K = 0.018 W/m deg K; Liquid at 233 deg K = 0.16 W/m deg K|Hydroxyl radical reaction rate constant = 5.90X10-12 cu cm/molec-sec at 25 °C

Highly flammable. PEROXIDE FORMING WHICH LEADS TO EXPLOSIONS

Hydrocarbons, Aliphatic Unsaturated

Highly Flammable

1-PROPYNE is highly flammable. The liquid material in cylinders contains about 30% propadiene. Detonation may occur at 95° C [MCA Case History No. 632]. Reacts exothermically with many oxidizing agents and with some reducing agents as well. May react with silver, copper, and mercury salts in aqueous solution to give explosive acetylides. Incompatible with brass that contains more than 65% copper, with other copper-containing alloys, with Monel metal, with neoprene, polyethylene, and, to a lesser extent, with Teflon. May enflame in air in the presence of Co, Hg, Hg salts, K, Ag, Ag salts, RbH, CsH, halogens, HNO3, NaH. Can decompose explosively when compressed to 4.5 to 5.6 atmospheres. Moderate explosion hazard when exposed to heat or flame or by spontaneous chemical reaction. Has been known to decompose explosively at high pressures and moderate temperatures in the absence of air.

Methyl acetylene|B: Compounds that form peroxides on concentration (distillation/evaporation)|Kelly

-1.8496X10+9 J/kmol

10.36 eV

Lower flammable limit: 1.7% by volume|Flammable limits in air, % by volume: Lower: 1.7; Upper: 11.7.|Flammable Gas

The gas is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

Critical temperature: 400.8 deg K; critical pressure: 5.35 MPa

2.1

UN 1954 2.1

-

R11;R37

S16-S36-S38

UK4250000

F:Flammable;Xi:Irritant;

Fireproof. Cool.

P210-P304 + P340 + P312-P377-P381-P410 + P403

H220-H280-H335

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|METHYL ACETYLENE MAY BE DISPOSED OF 1. IF IN SMALL QUANTITIES, BY ALLOWING THE GAS TO ESCAPE INTO OPEN AIR AT A PLACE WHERE THERE ARE NO IGNITION SOURCES. 2. IF IN LARGE QUANTITIES, BY ALLOWING THE GAS TO BURN UNDER THE SUPERVISION OF QUALIFIED PERSONNEL.

Can react vigorously with oxidizing materials.|Strong oxidizers (such as chlorine), copper alloys [Note: Can decompose explosively at 4.5 to 5.6 atmospheres of pressure].|Methyl acetylene forms compounds with copper and copper alloys that are very sensitive to shock.

UN 1954

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]: EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. Vapors from liquefied gas are initially heavier than air and spread along ground. CAUTION: Hydrogen (UN1049), Deuterium (UN1957), Hydrogen, refrigerated liquid (UN1966) and Methane (UN1971) are lighter than air and will rise. Hydrogen and Deuterium fires are difficult to detect since they burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. (ERG, 2016)|Extremely flammable. Gas/air mixtures are explosive.|Flammable - 4th degree, Reactive - 3rd degree

|Danger|H220 (98.55%): Extremely flammable gas [Danger Flammable gases]|P210, P261, P271, P304+P340, P312, P377, P381, P403, P403+P233, P405, P410+P403, and P501|Aggregated GHS information provided by 275 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H220: Extremely flammable gas [Danger Flammable gases]

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]: As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 800 meters (1/2 mile). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 1600 meters (1 mile) in all directions; also, consider initial evacuation for 1600 meters (1 mile) in all directions. In fires involving Liquefied Petroleum Gases (LPG) (UN1075); Butane, (UN1011); Butylene, (UN1012); Isobutylene, (UN1055); Propylene, (UN1077); Isobutane, (UN1969); and Propane, (UN1978), also refer to BLEVE - SAFETY PRECAUTIONS (ERG page 368). (ERG, 2016)

Excerpt from ERG Guide 115 [Gases - Flammable (Including Refrigerated Liquids)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. If possible, turn leaking containers so that gas escapes rather than liquid. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. Do not direct water at spill or source of leak. Prevent spreading of vapors through sewers, ventilation systems and confined areas. Isolate area until gas has dispersed. CAUTION: When in contact with refrigerated/cryogenic liquids, many materials become brittle and are likely to break without warning. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin from becoming frozen from contact with the liquid or from contact with vessels containing the liquid. Eyes: Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite. Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift). Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating. (NIOSH, 2016)|Compressed gases may create low temperatures when they expand rapidly. Leaks and uses that allow rapid expansion may cause a frostbite hazard. Wear appropriate personal protective clothing to prevent the skin from becoming frozen.|Wear appropriate eye protection to prevent eye contact with the liquid that could result in burns or tissue damage from frostbite.|Quick drench facilities and/or eyewash fountains should be provided within the immediate work area for emergency use where there is any possibility of exposure to liquids that are extremely cold or rapidly evaporating.|Respirator Recommendations: Up to 1700 ppm: (Assigned Protection Factor = 10) Any supplied-air respirator./(Assigned Protection Factor = 50) Any self-contained breathing apparatus with a full facepiece.|For more Personal Protective Equipment (PPE) (Complete) data for 1-PROPYNE (7 total), please visit the HSDB record page.|(See protection codes)

Dangerous, when exposed to heat or flame|Induced decomposition of the endothermic hydrocarbon leads to flame propagation in absence of air above minimum pressures of 3.4 and 2.1 bar at 20 and 120 °C, respectively.|The gas is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

Explosive in the form of vapor when exposed to heat or flame.|Explosive limits: Lower= 1.7%|The liquid material in cylinders (which contains around 30% of propadiene) is not shock-sensitive, but a wall temperature of 95 °C (even very localized) accompanied by pressures of about 3.5 bar, will cause a detonation to propagate from the hot spot.|Gas/air mixtures are explosive.|Explosive limits , vol% in air: 2.4-11.7

Shut off supply; if not possible and no risk to surroundings, let the fire burn itself out; in other cases extinguish with water spray ... Keep cylinder cool by spraying with water. Combat fire from a sheltered position.|To fight fire, stop the flow of gas.

On loss of containment this gas can cause suffocation by lowering the oxygen content of the air in confined areas.|The gas is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated.

Evacuate danger area! Ventilation. Remove all ignition sources. NEVER direct water jet on liquid. (Extra personal protection: chemical protection suit including self-contained breathing apparatus).|IF...LEAKED, THE FOLLOWING STEPS SHOULD BE TAKEN: 1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF LEAK TO DISPERSE GAS. 3. STOP FLOW OF GAS. IF SOURCE OF LEAK IS CYLINDER & LEAK CANNOT BE STOPPED IN PLACE, REMOVE...TO SAFE PLACE IN OPEN AIR, KEEP PEOPLE AWAY, & REPAIR THE LEAK OR ALLOW THE CYLINDER TO EMPTY.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Work clothing that becomes wet should be immediately removed due to its flammability hazard (i.e., for liquids with a flash point <100 °F).|NO open flames, NO sparks, and NO smoking ... Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (eg, by grounding) if in liquid state. Use non-sparking handtools. Prevent build-up of electrostatic charges (eg, by grounding). Local exhaust or breathing protection ... Local exhaust or breathing protection.|For more Preventive Measures (Complete) data for 1-PROPYNE (6 total), please visit the HSDB record page.

/GUIDE 115: GASES - FLAMMABLE (INCLUDING REFRIGERATED LIQUIDS)/ Fire or Explosion: EXTREMELY FLAMMABLE. Will be easily ignited by heat, sparks or flames. Will form explosive mixtures with air. Vapors from liquefied gas are initially heavier than air and spread along ground. ... Vapors may travel to source of ignition and flash back. Cylinders exposed to fire may vent and release flammable gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket. /Compressed gas, flammable, NOS (1-Propyne)/|/GUIDE 115: GASES - FLAMMABLE (INCLUDING REFRIGERATED LIQUIDS)/ Health: Vapors may cause dizziness or asphyxiation without warning. Some may be irritating if inhaled at high concentrations. Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite. Fire may produce irritating and/or toxic gases. /Compressed gas, flammable, NOS (1-Propyne)/|/GUIDE 115: GASES - FLAMMABLE (INCLUDING REFRIGERATED LIQUIDS)/ Public Safety: CALL Emergency Response Telephone Number. ... As an immediate precautionary measure, isolate spill or leak area for at least 100 meters (330 feet ) in all directions. Keep unauthorized personnel away. Stay upwind. Many gases are heavier than air and will spread along ground and collect in low or confined areas (sewers, basements, tanks). Keep out of low areas. /Compressed gas, flammable, NOS (1-Propyne)/|/GUIDE 115: GASES - FLAMMABLE (INCLUDING REFRIGERATED LIQUIDS)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. Always wear thermal protective clothing when handling refrigerated/cryogenic liquids. /Compressed gas, flammable, NOS (1-Propyne)/|For more DOT Emergency Guidelines (Complete) data for 1-PROPYNE (8 total), please visit the HSDB record page.

EFFECTS OF SHORT-TERM EXPOSURE:... /Propyne/ irritates the respiratory tract. Rapid evaporation of the liquid may cause frostbite. Exposure could cause lowering of consciousness.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1000 ppm (1650 mg/cu m).

Recommended Exposure Limit: 10 hr Time-Weighted avg: 1000 ppm (1650 mg/cu m).

Evacuate danger area! Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Remove all ignition sources. NEVER direct water jet on liquid.

Fireproof. Cool.

On loss of containment this substance can cause suffocation by lowering the oxygen content of the air in confined areas.

The substance is irritating to the respiratory tract. Rapid evaporation of the liquid may cause frostbite. Exposure could cause lowering of consciousness.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding) if in liquid state. Use non-sparking handtools. Prevent build-up of electrostatic charges (e.g., by grounding).

Use local exhaust or breathing protection.

Cold-insulating gloves.

Wear face shield.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily.| 3 - Materials that in themselves are capable of detonation or explosive decomposition or explosive reaction but that require a strong initiating source or must be heated under confinement before initiation.

In a study conducted by the Ford Motor Co, 1-propyne was identified as constituting 1.07-1.34% of the total hydrocarbon exhaust from a engine burning an isooctane fuel(1). In a Sydney, Australia study using 67 gasoline-fueled cars, the 1-propyne composition of hydrocarbon exhaust (excluding methane gas) was 0.4 to 0.5%(2). 1-Propyne was detected in the exhaust of spark-ignited engines burning gasoline and various olefinic fuels(3). 1-Propyne concns of <0.01 to 21.2 ppm were detected in the exhaust of turbojet engines operated at simulated supersonic flight conditions(4).

SOURCE DOMINATED: Ambient air monitoring conducted at 1000 ft heights at 5 locations over and downwind from a petroleum refinery (Benicia,CA) in Sept 1975 found 1-propyne at levels below 0.5 ug/cu m(1). 1-Propyne was released at levels below the quantification limit from emissions of two different ships, MS Aurora and Stena Danica that traveled from Denmark to Sweden during 1995(2). 1-Propyne in the air near roadways, lead smelter plants, and cast iron factories in Egypt comprised of 0.56, 0.06 and 0.17% of the non-methane organic contaminants respectively(3). 1-Propyne in the air at bus garages and from motorcycle emissions in Egypt comprised of 0.0.-0.2 and 0.2% of the non-methane organic contaminants in these areas respectively(3). 1-Propyne has been estimated to be about 3.87% of total emissions released in the exhaust of small engines(4).|URBAN/SUBURBAN: Sampling of air in Los Angeles, CA central business district on 9 days during Aug-Nov 1960 found 1-propyne concns ranging from <0.5 ppb (detection limit) to 6 ppb(1). Air monitoring of heavy afternoon haze in Riverside, CA during Aug-Nov 1965 found 1-propyne levels of 0-1.4 ppb(2). Ambient air monitoring conducted in Sydney, Australia during May 1979 to June 1980 (140 total air samples) found an avg 1-propyne concn of 0.5 ppb(3). 1-Propyne was detected in the air of Taipei with an average concentration of 0.4 ppbv and not detected in Hamburg, Germany; Chicago, Il; Athens, Greece or Osaka, Japan(4).|RURAL/REMOTE: An atmospheric concn of 0.054 ppb was detected at a rural site in Egbert, Ontario in Apr 1990(1). 1-Propyne was detected not quantified in the air above the Boden Forest, Canada from April 29-June 3 1993(2).

1-Propyne's production and use as a synthetic intermediate, specialty and welding torch fuel(1,2) as well as its emission as a byproduct of automobile and turbine engine combustion(3) result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 77(SRC), determined from a log Kow of 0.94(2) and a regression-derived equation(3), indicates that 1-propyne is expected to have high mobility in soil(SRC). Volatilization of 1-propyne from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC), derived from its vapor pressure, 4.31X10+3 mm Hg(4), and water solubility, 3,640 mg/L(5). 1-Propyne is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). 1-Propyne readily volatilizes from dry and moist soil surfaces. 1-Propyne volatilizes readily from water and moist soil surfaces; therefore, biodegradation studies in these environments are difficult(SRC). Biodegradation studies in soil were not located(SRC, 2006).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 77(SRC), determined from a log Kow of 0.94(2) and a regression-derived equation(3), indicates that 1-propyne is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.011 atm-cu m/mole(SRC) derived from its vapor pressure, 4.31X10+3 mm Hg(4), and water solubility, 3,640 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 41 min and 2.5 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 1-Propyne volatilizes readily from water and moist soil surfaces; therefore, biodegradation studies in these environments are difficult(SRC). Biodegradation studies in water were not located(SRC, 2006).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-propyne, which has a vapor pressure of 4.31X10+3 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase 1-propyne is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.7 days(SRC), calculated from its rate constant of 5.9X10-12 cu cm/molecule-sec at 25 °C(3). 1-Propyne does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4).

The rate constant for the vapor-phase reaction of 1-propyne with photochemically-produced hydroxyl radicals has been estimated as 5.9X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 2.7 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Alkynes are generally resistant to hydrolysis(2); therefore, 1-propyne is not expected to hydrolyze in the environment(SRC). 1-Propyne does not absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(2). The rate constant for the vapor-phase reaction of 1-propyne with ozone has been estimated as 1.43X10-20 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(1). This corresponds to an atmospheric half-life of about 800 days at an atmospheric concentration of 7X10+11 ozone molecules per cu cm(3).

An estimated BCF of 3 was calculated in fish for 1-propyne(SRC), using a log Kow of 0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Koc of 1-propyne is estimated as 77(SRC), using a log Kow of 0.94(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 1-propyne is expected to have high mobility in soil.

The Henry's Law constant for 1-propyne is estimated as 1.1X10-2 atm-cu m/mole(SRC) derived from its vapor pressure, 4.31X10+3 mm Hg(1), and water solubility, 3,640 mg/L(2). This Henry's Law constant indicates that 1-propyne is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 41 minutes(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 2.5 days(SRC). 1-Propyne's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of 1-propyne from dry soil surfaces may exist(SRC) based upon the vapor pressure(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 119 workers (6 of these are female) are potentially exposed to 1-propyne in the US(1). Occupational exposure to 1-propyne may occur through inhalation of this compound at workplaces where 1-propyne is produced or used(SRC). The most likely pathway by which the general public is exposed to 1-propyne is by inhalation due to the release of this substance from combustion fuels, biomass emissions and cigarette smoke(SRC).

1-Propyne has been detected in the human respiratory air at 0.81 ug/hr in a non-smoker and at 1.1 and 2.3 ug/hr in two smokers(1).

Propyne has been detected in exhaled air at 0.81 mg/hr in nonsmokers, and at 1.1 and 2.3 mg/hr in smokers.|... /Propyne/ can be absorbed into the body by inhalation.

Exposure Routes: inhalation, skin and/or eye contact (liquid) Symptoms: Irritation respiratory system; tremor, hyperexcitability, anesthesia; liquid: frostbite Target Organs: respiratory system, central nervous system (NIOSH, 2016)

Eye: If eye tissue is frozen, seek medical attention immediately; if tissue is not frozen, immediately and thoroughly flush the eyes with large amounts of water for at least 15 minutes, occasionally lifting the lower and upper eyelids. If irritation, pain, swelling, lacrimation, or photophobia persist, get medical attention as soon as possible. Skin: If frostbite has occurred, seek medical attention immediately; do NOT rub the affected areas or flush them with water. In order to prevent further tissue damage, do NOT attempt to remove frozen clothing from frostbitten areas. If frostbite has NOT occurred, immediately and thoroughly wash contaminated skin with soap and water. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. (NIOSH, 2016)|(See procedures)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

ON FROSTBITE: rinse with plenty of water, do NOT remove clothes.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

FIRST AID: Inhalation--Fresh air, rest. Artificial respiration if indicated. Refer for medical attention ... Skin--ON FROSTBITE: rinse with plenty of water, do NOT remove clothes. Eyes--First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.

/SIGNS AND SYMPTOMS/ ACUTE ... SYMPTOMS: Inhalation--dizziness, headache, nausea, unconsciousness. Skin--ON CONTACT WITH LIQUID: FROSTBITE.|/CASE REPORTS/ A 33-year-old man died after intentionally inhaling a gaseous mix of methyl acetylene (propyne) and propadiene (allene) ... A comprehensive toxicological analysis revealed only a trace of diphenhydramine in the liver and 0.02 mg/L of morphine in the urine. Analysis of blood by headspace gas chromatography (HS-GC) detected two unknown peaks. ... MAPP was quantitated in femoral blood (59.6 mg/L) and brain (43.6 mg/kg) using a HS-GC method.|/BIOMONITORING/ Gas chromatography/mass spectrometry has been used to measure propyne in exhaled air.|/OTHER TOXICITY INFORMATION/ Propyne is 18 times as potent as acetylene in causing CNS depression.

methylacetylene

The substance can be absorbed into the body by inhalation.|inhalation, skin and/or eye contact (liquid)

irritation respiratory system; tremor, hyperexcitability, anesthesia; liquid: frostbite

Dizziness. Headache. Nausea. Unconsciousness.

ON CONTACT WITH LIQUID: FROSTBITE.

respiratory system, central nervous system

All other basic organic chemical manufacturing|1-Propyne: ACTIVE

MATRIX: AIR; PROCEDURE: COLLECTION IN GAS SAMPLING BAG, GC WITH FLAME IONIZATION.|METHODS FOR SAMPLING & ANALYSIS OF TOXIC SUBSTANCES INCLUDING 1-PROPYNE IN WORKPLACE.|Method: NIOSH S84; Procedure: gas chromatography with flame ionization detection; Analyte: 1-propyne; Matrix: air; Detection Limit: 10 ng.

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Fire Hazards -> Flammable - 4th degree, Reactive - 3rd degree