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Mefruside

Mefruside structure

CAS No:
7195-27-9
Formula:
C13H19ClN2O5S2
Chemical Name:
Mefruside
Synonyms:
1,3-Benzenedisulfonamide,4-chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-;m-Benzenedisulfonamide,4-chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-;4-Chloro-N1-methyl-N1-[(tetrahydro-2-methyl-2-furanyl)methyl]-1,3-benzenedisulfonamide;4-Chloro-N1-methyl-N1-(tetrahydro-2-methylfurfuryl)-m-benzenedisulfonamide;N-(4′-Chloro-3′-sulfamoylbenzenesulfonyl)-N-methyl-2-aminomethyl-2-methyltetrahydrofuran;Mefruside;B 1500;Baycaron;FDA 1902;N-(4-Chloro-3-sulfamoylbenzenesulfonyl)-N-methyl-2-furfurylamine;Mefrusid;FBA 1500;BAY 1500
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

Description

Mefruside is an organic molecular entity.|A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level.

Mefruside Basic Attributes

Molecular Weight：

382.874

Exact Mass：

382.88

EC Number：

230-562-4

DSSTox ID：

DTXSID0048844

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

124

XLogP3：

4.03890

Density：

1.417g/cm3

Melting Point：

148-150 °C

Boiling Point：

565.2ºC at 760 mmHg

Flash Point：

295.6ºC

Refractive Index：

1.571

Toxicity：

LD50 oral in rabbit: > 3gm/kg

Drug Information

MeSH：

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

MeSH Entry Terms：

Mefruside

Mefruside Use and Manufacturing

Uses

Mefruside is a diuretic used for the treatment of edema and hypertension.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:382.9
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:382.0423918
Monoisotopic Mass:382.0423918
Topological Polar Surface Area:124
Heavy Atom Count:23
Complexity:628
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes