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Epristeride

Epristeride structure

CAS No:
119169-78-7
Formula:
C25H37NO3
Chemical Name:
Epristeride
Synonyms:
Androsta-3,5-diene-3-carboxylic acid,17-[[(1,1-dimethylethyl)amino]carbonyl]-,(17β)-;(17β)-17-[[(1,1-Dimethylethyl)amino]carbonyl]androsta-3,5-diene-3-carboxylic acid;SKF 105657;17β-(tert-Butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid;Epristeride;N-tert-Butylandrosta-3,5-diene-17β-carboxamide-3-carboxylic acid;ONO 9302
Categories:
Active Pharmaceutical Ingredients > Urinary System Drugs

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Description

Epristeride is a novel 5α-reductase inhibor.

Epristeride is a steroid acid.

Epristeride Basic Attributes

Molecular Weight：

399.57

Exact Mass：

399.57

UNII：

39517A04PS

DSSTox ID：

DTXSID9048643

Characteristics

PSA：

66.40000

XLogP3：

5.49190

Density：

1.13±0.1 g/cm3(Predicted)

Melting Point：

242-249 °C

Boiling Point：

596.0±50.0 °C(Predicted)

Flash Point：

314.3ºC

Refractive Index：

1.563

Collision Cross Section：

206.6 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated]

Drug Information

MeSH：

Drugs that inhibit 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. They are commonly used to reduce the production of DIHYDROTESTOSTERONE. (See all compounds classified as 5-alpha Reductase Inhibitors.)

MeSH Entry Terms：

17-N-t-butylcarboxamide androst-3,5-diene-3-carboxylic acid

Epristeride Use and Manufacturing

Inhibitor (alpha reductase.

Computed Properties

Molecular Weight:399.6
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:399.27734404
Monoisotopic Mass:399.27734404
Topological Polar Surface Area:66.4
Heavy Atom Count:29
Complexity:788
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetic acid

Ethyl bromide

tert-Butylamine

Oxalyl chloride

Drug Function and Efficacy

Epristeramide is a new type of anti-competitive 5alpha-reductase inhibitor, which can form a ternary complex with 5alpha-reductase and NADF, thereby inhibiting the conversion of testosterone into dihydrotestosterone and reducing the water content of dihydrotestosterone in the prostate, leading to the atrophy of the hyperplastic prostate, thus achieving the purpose of treating prostate hyperplasia.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Apretil Tablets
Ingredients	Main ingredients: The main ingredient of this product is: Aprelet. Its chemical name is: 17??-(N-tert-butyl-amino-formyl)androsta-3,5-diene-3-carboxylic acid. Molecular formula: C25H37NO3 Molecular weight: 399.57
Indication	None found so far.
Specifications	5 mg
Manufacturer	Jiangsu Lianhuan Pharmaceutical Co., Ltd.

Aplita
Ingredients	Aprelet, chemical name: 17b-(N-tert-butylcarbamoyl)androsta-3,5-diene-3-carboxylic acid
Specifications	API
Manufacturer	Jiangsu Lianhuan Pharmaceutical Co., Ltd.

Registered Holders

Jiangsu Lianhuan Pharmaceutical Co., Ltd.

China
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