Stop

156.71

157.899002

231-999-3

0860

2811|3288

DTXSID6064822

Monoclinic, lamellar plates|White, monoclinic crystalline powder

A - Alimentary tract and metabolism

28261990

0 Ų

0.45960

White to off-white Powder, Crystals or Crystalline Powder

4.57 g/cm³ @ Temp: 25 °C

213 °C

850 °C

soluble in potassium hydroxide and potassium fluoride. Insoluble in water, ethanol, ether and chloroform.

-20°C

BITTER, SALTY TASTE

2.8-3.5 (0.4% AQ SOLN)

Forms an oxyfluoride, SnOF2 on exposure to air.

Water soluble.

Salts, Acidic

STANNOUS FLUORIDE, a reducing agent, is incompatible with oxidizers. Avoid contact with acids - HF fumes may be produced (USCG, 1999).

II

8

UN 2923 8/PG 3

3

22-38-41

26-39

XQ3450000

Xn,C

Corrosive

Stable. Non-flammable. Avoid contact with water or oxidizing agents. Moisture-sensitive.

P280-P301 + P312 + P330-P305 + P351 + P338 + P310

H302-H315-H318

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Avoid contact with acids, hydrogen fluoride fumes may be produced.|THE REACTION OF CHLORINE & STANNOUS FLUORIDE OCCURS WITH FLAMING.|Incompatible with alkaline substances and oxidizing agents.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)|Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

|Danger|H302 (89.83%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P362, P363, P405, and P501|Aggregated GHS information provided by 154 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H300: Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P301+P310, P304+P340, P312, P321, P330, P403+P233, P405, and P501|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P310, P304+P340, P305+P351+P338, P312, P314, P321, P330, P337+P313, P403+P233, P405, and P501

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)|In case of fire in the surroundings, use appropriate extinguishing media.

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Goggles and dust mask. (USCG, 1999)|Safety goggles or face shields should be worn (8 inch minimum). Impervious clothing should include gloves, aprons, and suits. /Organotin compounds/|Personnel protection: ... Wear appropriate chemical protective gloves, boots and goggles. ... /Organotin compounds, NOS/|Skin contact should be prevented by protective clothing. /Tin & inorganic tin cmpd/|Recommendations for respirator selection: Max. concn for use: 1 mg/cu m). Any chemical cartridge respirator with organic vapor cartridge(s) in combination with a dust and mist filter. Any supplied-air respirator. /Tin (organic cmpds, as Sn)/|For more Personal Protective Equipment (PPE) (Complete) data for STANNOUS FLUORIDE (9 total), please visit the HSDB record page.

Not flammable

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. All contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Wherever possible, safer substitutes should be used in the place of alkyltin compounds. When it is necessary to make and use them ... /handling should be done in/ enclosed systems ... /equipped with/ exhaust ventilation. Engineering control should ensure that exposure limits are not exceeded. Personal protective equipment should be worn, & in appropriate circumstances respiratory protection should be used. Emergency showers should be installed ... to allow workers to wash immediately after splashes. /Organotin compounds/|SRP: The scientific literature supports the wearing of contact lenses in industrial environments, as part of a program to protect the eye against chemical compounds and minerals causing eye irritation. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases contact lenses should not be worn.|Eating, smoking, and food preparation or dispensing (including vending machines) shall be prohibited where organotin compounds are being used. /Organotin compounds/|For more Preventive Measures (Complete) data for STANNOUS FLUORIDE (11 total), please visit the HSDB record page.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 2.5 mg/cu m. /Fluorides, as F/

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers.

Separated from acids, chlorine and food and feedstuffs.

A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.

Corrosive on ingestion. The substance is irritating to the eyes.

The substance may have effects on the teeth and bones (fluorosis).

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles or eye protection in combination with breathing protection.

The oral LD50 value in rats is 360mg/kg and the dermal LD50 value is >2000mg/kg. Repeated or prolonged dermal contact can cause irritant symptoms such as reddening of the skin, blisters, or dermatitis.

LD50 MOUSE ORAL 112 MG/KG|LD50 RAT ORAL 200-300 MG/KG|LD50 SWISS WHITE MOUSE ORAL (ADMIN BY STOMACH TUBE) 31.2 MG/KG BODY WT|LD50 ROCHESTER RAT ORAL (ADMIN BY STOMACH TUBE) 45.7 MG/KG BODY WT|For more Non-Human Toxicity Values (Complete) data for STANNOUS FLUORIDE (6 total), please visit the HSDB record page.

Indicated for use to relieve dental hypersensitivity, increase enamel production, prevent gingivitis and cavities, and control periodontal infections.

Stannous fluoride is applied directly to the surfaces of teeth in the form of solutions or gels for the prevention of dental caries in children.|Dilute solutions of gels containing 0.4% stannous fluoride have been used to prevent decalcification in orthodonic patients and to protect against postirradiation caries.|The ADA currently states that topical application of 8% aqueous solution of stannous fluoride at 6 to 12 month intervals is the preferred method of administration. Prior to topical application of the 8% solution, the teeth should be thoroughly cleaned, isolated with cotton rolls, and dried with compressed air. The teeth are then kept moist with a freshly prepared 8% solution of stannous fluoride for a 4 minute period. Topical application of 8% aqueous solutions of stannous fluoride should be repeated at 6 to 12 month intervals. Less concentrated solutions or gels of stannous fluoride may be applied topically daily or every other day with a toothbrush or as a rinsing solution. For self administration in adults and children 6 years of age and older, a 0.4% gel can be applied to the teeth and then thoroughly brushed once daily; the gel should then be allowed to remain on the teeth for 1 minute before expectorating. For self-administration of a 0.1% rinsing solution, 10 ml is generally administered once daily in adults and children 6 years of age and older ... .

Staining or pigmentation (eg, yellow, brown, brown black) of the teeth resulting from topical application of concentrated solutions or gels of stannous fluoride has been reported, particularly in patients with poor oral hygiene. The pigmentation, which is probably stannous sulfide, is generally associated with a carious lesion or a hypocalcified area of the enamel or with plaque or accumulated debris, or occurs at the margin of a silicate restoration. Staining has also occurred with stannous fluoride containing dentifrices, but the risk of staining with these dentifrices appears to be less than that with stannous fluoride containing solutions or gels because the latter preparations do not contain abrasives, they are in contact with teeth for longer periods of time after application, and the mouth is not rinsed with water after application. To minimize the risk of staining, individuals receiving stannous fluoride containing preparations should be advised of the importance of good oral hygiene (eg, adequate brushing). These individuals should also be advised that such staining is not harmful or permanent and can be removed by a dentist or dental hygienist.|Food and Environmental Agents: Effect on Breast-Feeding: Reported Sign or Symptom in Infant or Effect on Lactation: Fluorides: None. /from Table 7/

Stannous fluoride mediates both bactericidal and bacteriostatic properties and provides an anti-erosive action on tooth enamel.

Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed) (See all compounds classified as Cariostatic Agents.)

Tin is retained in the demineralized organic matrix to some extent, diffuses through the phosphorylated non-collagenous proteins in the dentine called phosphophoryn and accumulates in the underlying mineralized tissue.|Materials introduced into the oral cavity can be eliminated by salivary washout and swallowing, absorption through oral surfaces, or degradation.|Stannous fluoride is cleared from saliva rapidly but very well retained in gingival plaque for a prolonged period of time.|Stimulated and nonstimulated salivary elimination microrate constants in this case would be ∼1 and 0.5 min^−1, respectively.|Fluoride ion is rapidly & extensively absorbed from the gut. In rats, absorption of sodium fluoride ... & stannous fluoride is similar.|Fluoride is transported in the blood in the free rather than the protein-bound form; it is distributed rapidly throughout all soft tissues but is not accumulated. /Fluoride ion/|THE PLACENTA OF RATS WAS PERMEABLE TO FLUORIDE @ 25 PPM IN DRINKING WATER JUST BEFORE OR DURING GESTATION. LESS THAN 1% ADMIN TO PREGNANT RATS WAS TRANSFERRED IN PROGENY, INDICATING STRONG DISCRIMINATION AGAINST TRANSPLACENTAL TRANSFER. NO DIFFERENCE IN THE TRANSFERRED AMT WAS OBSERVED WHEN FLUORIDE WAS GIVEN AS SODIUM FLUORIDE OR TIN FLUORIDE.|THE FATE OF (113)TIN HAS BEEN EVALUATED IN THE RAT FOLLOWING THE ADMINISTRATION OF (113)TIN(II) AND (113)TIN(IV). CHANGING THE ANION COMPLEMENT FROM FLUORIDE TO CITRATE DID NOT AFFECT THE BIOLOGICAL FATE OF EITHER VALENCE FORM OF TIN. FROM A SINGLE PER ORAL DOSE OF 20 MG OF TIN(II) OR TIN(IV)/KG, 2.85 AND 0.64%, RESPECTIVELY, WERE ABSORBED. WITHIN 48 HR, ABOUT 50% OF THE ABSORBED TIN WAS EXCRETED. THE TISSUE DISTRIBUTION OF THE TIN REPORTED AS A PERCENT OF THE DOSED TIN(II) AND TIN(IV), RESPECTIVELY, WAS SKELETON 1.02 AND 0.24, LIVER 0.08 AND 0.02, AND KIDNEYS 0.09 AND 0.02. FROM A SINGLE IV DOSE OF 2 MG OF TIN(II) OR TIN(IV)/KG, ABOUT 30% WAS EXCRETED IN THE URINE; 11% OF THE TIN(II) WAS ELIMINATED IN THE BILE, BUT NONE OF THE TIN(IV). THE AVERAGE PERCENT OF TIN ABSORBED DURING A 28-DAY PER ORAL DOSING STUDY WAS LESS THAN FROM A SINGLE PER ORAL DOSE. IN A COMPARISON OF THE TIN IN TISSUES FROM A SINGLE AND FROM A 28-DAY PER ORAL DOSING, ONLY BONE HAD AN INCREASED ACCUMULATION APPROXIMATELY PROPORTIONAL TO THE INCREASED AMOUNT OF SYSTEMIC EXPOSURE.|For more Absorption, Distribution and Excretion (Complete) data for STANNOUS FLUORIDE (7 total), please visit the HSDB record page.

The half-life for the decay of the salivary elimination rate constant was 13 min.|THE FATE OF (113)TIN HAS BEEN EVALUATED IN THE RAT FOLLOWING THE ADMINISTRATION OF (113)TIN(II) AND (113)TIN(IV). ... THE BIOLOGICAL HALF-LIFE OF THE TIN IN BONES WAS CALCULATED TO BE 20 TO 40 DAYS.

Stannous fluoride has been shown to manage and prevent dental caries and gingivitis by promoting enamel mineralization, reducing gingival inflammation and bleeding, its potential broad-spectrum antibiotic effect, and through modulation of the microbial composition of the dental biofilm. It works by depositing a stable acid-resistant layer on the tooth surfaces which is composed of calcium fluoride produced when stannous fluoride converts the calcium mineral apatite into fluorapatite. Tin and fluoride mediate anti-erosive actions by interacting with and modifying the absorbent layer composed of salivary proteins such as mucins, perhaps by enhancing the cross-linking between the proteins to result in a more resistant and protective layer against erosion. The efficacy of stannous fluoride solutions seems to depend mainly on the incorporation of tin in the mineralized dentine when the organic portion is preserved but on surface precipitation when the organic portion is continuously digested. Moreover, the relative erosion-inhibiting effects of stannous fluoride strongly depend on the presence or absence of the demineralized organic dentine matrix.|DENTAL STUDENTS RINSED FOR 4 DAYS WITH 0.2% AQ SOLN STANNOUS FLUORIDE OR STANNIC TETRACHLORIDE & IN ADDITION 15% SUCROSE TO ENHANCE PLAQUE FORMATION. TIN(2+) SHOWED MARKED INHIBITING ACTIVITY WHEREAS THE TIN(4+) SHOWED ONLY SLIGHT EFFECT. THE TIN(2+) ION ALSO REDUCED THE ACIDOGENICITY OF THE DENTAL PLAQUE WHEREAS THE TIN(4+) SHOWED NO EFFECT. TIN(2+) REDUCES METABOLIC ACTIVITY OF PLAQUE BY OXIDIZING THIOL GROUPS BY AFFINITY FOR THEM. THIS IS NOT THE CASE FOR TIN(4+).|/STANNOUS FLUORIDE/ ... ALTERS THE COMPOSITION & CRYSTALLINE STRUCTURE OF THE HYDROXYAPATITE-LIKE SALTS THAT MAKE UP THE BULK OF ENAMEL, ESPECIALLY, & DENTIN, SO THAT THE TOOTH MATERIAL IS MORE RESISTANT TO ACIDIC EROSION & DENTAL CARIES (DECAY).|When stannous fluoride is applied topically to teeth, a highly adherent surface coating composed mainly of tin phosphate and smaller amounts of calcium fluoride and a tin hydroxyorthophosphate is formed on enamel.|IN A STANDARDIZED RABBIT MODEL, YELLOW GOLDEN STAIN FORMED ON TOOTH SURFACES DURING USE OF STANNOUS FLUORIDE IS DUE TO ITS LOW PH WHICH CAUSES DENATURATION OF PELLICLE PROTEIN WITH EXPOSURE TO SULFHYDRYL GROUPS, WHICH FORM STANNIC SULFIDES THROUGH REACTIONS WITH TIN(2+).

... 0.2% insoluble substances and 50 mg/kg of antimony /in USP grade/.|Grades of purity: 97.5%

EYES: Severe irritation - corrosive, irreversible. SKIN: Corrosive on abraded skin, no effect on intact skin. (USCG, 1999)

EYES: Flush with plenty of water for at least 15 minutes. SKIN: Flush with soap and water. INGESTION: Induce vomiting. Get medical attention. (USCG, 1999)

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. ... . Cover skin burns with dry sterile dressings after decontamination ... . /Fluorine and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W. Use lactated Ringer's to support vital signs if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluids cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Fluorine and related compounds/

At concn present in commercial dentifrice formulations (about 1 mg fluoride per g), neither fluoride nor tin presents an appreciable toxic hazard on an acute or chronic basis.|A 5 MINUTE APPLICATION OF 8% STANNOUS FLUORIDE TO DEEP CAVITIES IN HUMAN TEETH COULD PRODUCE LOCAL NECROSIS AND MODERATE INFLAMMATION OF THE PULP ADJACENT TO THE CAVITY FLOOR. NO SUCH EFFECTS WERE OBTAINED AFTER A 30 SECOND APPLICATION.|STAINING OR PIGMENTATION ... OF TEETH RESULTING FROM TOPICAL APPLICATION OF CONCN SOLN OR GELS OF STANNOUS FLUORIDE HAS BEEN REPORTED ESPECIALLY IN PATIENTS WITH POOR ORAL HYGIENE. THE PIGMENTATION WHICH IS PROBABLY STANNOUS SULFIDE, IS GENERALLY ASSOCIATED WITH A CARIOUS LESION OR A HYPOCALCIFIED AREA OF THE ENAMEL, OR WITH PLAQUE. ...|Symptoms of acute fluoride overdosage include hypersalivation, a salty or soapy taste, epigastric pain, nausea, vomiting, burning or crampy abdominal pain, diarrhea, dehydration, thirst, localized or generalized urticaria, muscle weakness, tremors, and, rarely, transient epileptiform seizures. Shock may occur and is characterized by pallor, weak and thready pulse which may be irregular, wet cold skin, dilated pupils, cyanosis, shallow unlabored respiration, and weak heart sounds. Death may result from cardiac failure, respiratory arrest, or shock and usually occurs within 2-4 hr following ingestion; if a victim survives the first 24 hr, the prognosis is good. When death is delayed, paralysis of the muscles of deglutition, carpopedal spasm, and spasm of the extremities may occur. /Fluorides/|For more Human Toxicity Excerpts (Complete) data for STANNOUS FLUORIDE (9 total), please visit the HSDB record page.

Cav-X

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Cough. Sore throat.

Redness. Pain.

Grade: NF (National Formulary)|STANNOUS FLUORIDE IS AVAILABLE ... AS A USP GRADE CONTAINING A MIN OF 71.2% STANNOUS TIN AND 22.3-25.5% FLUORIDE ON AN ANHYDROUS BASIS, AND A MAX OF 0.5% WEIGHT LOSS ON DRYING, 0.2% INSOLUBLE SUBSTANCES AND 50 MG/KG ANTIMONY.|Stannous fluoride for oral topical use comes in the following 0.4% (0.1% fluoride ion) gels: EASYgel (with glycerin), Du-More; Gel-Kam (with glycerin), Scherer; Gel-Tin (with glycerin), Young Dental; Omnii-Gel (with glycerin), Dunhall; Stop Home Treatment 0.4% (with glycerin). A 30% (7.2% fluoride ion) solution is available as Oral-B rinsing solution, concentrate.|-4 mesh, 99.9% purity grades.|For more Formulations/Preparations (Complete) data for STANNOUS FLUORIDE (6 total), please visit the HSDB record page.

Tin fluoride (SnF2): ACTIVE|Stannous fluoride is provisionally allowed for use in oral hygiene products in the European Communities, provided that, when mixed with other permitted fluorine cmpd, the total fluoride concn does not exceed 0.15%.|STANNOUS FLUORIDE WAS THE ANTICARIES AGENT IN THE FIRST FLUORIDE TOOTHPASTE MARKETED IN THE USA IN THE 1950'S ... .

Cosmetics -> Antiplaque; Oral care