Lincomycin hydrochloride monohydrate
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Lincomycin hydrochloride monohydrate
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CAS No:
7179-49-9
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Formula:
C18H34N2O6S.ClH.H2O
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Chemical Name:
Lincomycin hydrochloride monohydrate
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Synonyms:
D-erythro-α-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,hydrochloride,hydrate (1:1:1);D-erythro-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride,monohydrate,trans-α-;D-erythro-α-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,monohydrochloride,monohydrate,(2S-trans)-;D-erythro-α-D-galacto-Octopyranoside,methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-,monohydrochloride,monohydrate;Lincomycin hydrochloride monohydrate;Lincomycin hydrochloride hydrate;1236362-91-6
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CAS No:
Description
Crystalline
Lincomycin Hydrochloride is the hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete Streptomyces lincolnensis with activity against gram-positive cocci and anaerobic bacteria.|An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.
Lincomycin hydrochloride monohydrate Basic Attributes
442.99800
442.19000
212-726-7
M6T05Z2B68
C66013
2941904000
Characteristics
147.79000
0.27380
Crystalline
145-147 °C
646.8ºC at 760 mmHg
345ºC
Soluble in water.
2-8ºC
Safety Information
2
R36/37/38
S26
Xi
P261; P305 + P351 + P338
H315; H319; H335
|Danger|H315 (40%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)
Epilincomycin
Lincomycin hydrochloride monohydrate Use and Manufacturing
1. An antibiotic produced by Streptomyces lincolnensis. Lincomycin is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.
2. Antibacterial;Ribosomal protein synthesis inhibitor
3. Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Computed Properties
Molecular Weight:461.0
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:460.2010004
Monoisotopic Mass:460.2010004
Topological Polar Surface Area:149
Heavy Atom Count:29
Complexity:499
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Price Analysis
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Lincomycin hydrochloride monohydrate
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