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Fursultiamine

Fursultiamine structure

CAS No:
804-30-8
Formula:
C17H26N4O3S2
Chemical Name:
Fursultiamine
Synonyms:
Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]-;Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]-;Formamide,N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]-;N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]formamide;Alinamin F;N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide;Fursultiamine;Judolor;Thiamine tetrahydrofurfuryl disulfide;TTFD;Tetrahydrofurfuryl thiamine disulfide;Diteftin;Adventan;Fursultiamin;Linamin;Retar B1;Thiamin tetrahydrofurfuryl disulfide;2088-19-9
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

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Description

Fursultiamine is a vitamin B1 derivative.

Fursultiamine Basic Attributes

Molecular Weight：

398.54

Exact Mass：

398.54

EC Number：

212-357-1

Characteristics

PSA：

152

XLogP3：

0.6

Density：

1.29 g/cm³

Melting Point：

132 °C (decomp)

Boiling Point：

652.3°C at 760 mmHg

Flash Point：

348.3±31.5 °C

Refractive Index：

1.626

Toxicity：

LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine Use and Manufacturing

It is an active derivative of vitamin B1, which is characterized by not being destroyed by thiamine enzyme in the body, so it is absorbed quickly and has a long-lasting effect

Computed Properties

Molecular Weight:398.5
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:9
Exact Mass:398.14463305
Monoisotopic Mass:398.14463305
Topological Polar Surface Area:152
Heavy Atom Count:26
Complexity:481
Undefined Atom Stereocenter Count:1
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acrylonitrile

Dimethyl sulfate

Drug Function and Efficacy

Fusultiamine is a new derivative of vitamin B1. It is rapidly converted into active thiamine in the body and is not decomposed by thiaminase in the body. It has strong affinity for tissues, high concentrations in organs and blood, and can be maintained for a long time. It has the characteristics of high efficiency, long-term effect, and low toxicity. Like vitamin B1, active thiamine combines with pyrophosphate in the body to form a coenzyme, which participates in the oxidative decarboxylation reaction of pyruvate and a-ketoglutaric acid in sugar metabolism and is necessary for sugar metabolism. When it is deficient, oxidation is blocked to form pyruvate, lactic acid accumulates, and affects the body's energy supply. Its symptoms are mainly manifested in the nervous and cardiovascular systems, with multiple peripheral neuritis affecting both sensory nerves and motor nerves, manifested as paresthesia, neuralgia, limb weakness, and muscle soreness and atrophy.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Fusultiamine Injection
Ingredients	The main ingredient of this product is fursultiamine, and its chemical name is N-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-N-{4-hydroxy-1-methyl-2-[(tetrahydrofuranmethyl)disulfide]-1-butenyl}formamide.
Indication	This product is easily decomposed in alkaline solution and may deteriorate when combined with alkaline drugs such as sodium bicarbonate and sodium citrate.
Specifications	2ml:20mg
Manufacturer	Chengdu Brilliant Pharmaceutical Co., Ltd.

Fusultiamine Tablets
Ingredients	The main ingredient of this product is fursultiamine. Its chemical name is: N-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-N-{4-hydroxy-1-methyl-2-[(tetrahydrofuranmethyl)disulfide]-1-butenyl}formamide.
Indication	This product is easily decomposed in alkaline solution and may deteriorate when combined with alkaline drugs such as sodium bicarbonate and sodium citrate.
Specifications	50mg
Manufacturer	Shaanxi Sun Simiao High Tech Pharmaceutical Co., Ltd.

Fusultiamine Tablets
Ingredients	The main ingredient of this product is fursultiamine. Its chemical name is: N-[(4-amino-2-methyl-5-pyrimidinyl)-methyl]-N-{4-hydroxy-1-methyl-2-[(tetrahydrofuranmethyl)disulfide]-1-butenyl}formamide.
Indication	This product is easily decomposed in alkaline solution and may deteriorate when combined with alkaline drugs such as sodium bicarbonate and sodium citrate.
Specifications	25 mg

See More Related Drugs

Registered Holders

Minsheng Group Shaoxing Pharmaceutical Co., Ltd.

China
Active
Shanghai Zhongxi Sunve Pharmaceutical Co., Ltd.

China
Active

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