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Deoxyinosine

Deoxyinosine structure

Deoxyinosine 

structure
  • CAS No:

    890-38-0

  • Formula:

    C10H12N4O4

  • Chemical Name:

    Deoxyinosine

  • Synonyms:

    Inosine,2′-deoxy-;2′-Deoxyinosine;Hypoxanthine,9-(2-deoxy-β-D-erythro-pentofuranosyl)-;Deoxyinosine;9-(2-Deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one;6H-Purin-6-one,9-(2-deoxy-β-D-erythro-pentofuranosyl)-1,9-dihydro-;Hypoxanthine deoxyriboside;1049662-95-4

  • Categories:

    Biochemical Engineering  >  Nucleoside Drugs

Description

2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.


Solid


2'-deoxyinosine is a purine 2'-deoxyribonucleoside that is inosine in which the hydroxy group at position 2' is replaced by a hydrogen. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, a plant metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It derives from an inosine.

Deoxyinosine Basic Attributes

252.23

252.23

212-964-1

HN0RQ6SBWQ

2934999090

Characteristics

109

-1.7

White to Off-white Powder

1.9±0.1 g/cm3

>250 °C (decomp)

681.2°C at 760 mmHg

329.1±34.3 °C

1.837

8.33g/L(25.02 ºC)

−20°C

21 º (c=1, H2O 22 ºC)

151.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|153.4 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]

Safety Information

NONH for all modes of transport

3

20/21/22-36/37/38

24/25-37/39-36-26

Xn,Xi

Stable under normal temperatures and pressures.

Drug Information

2'-deoxyinosine

Deoxyinosine Use and Manufacturing

An Inosine (I661000) analog with hypotensive activity. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).

Computed Properties

Molecular Weight:252.23
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:252.08585488
Monoisotopic Mass:252.08585488
Topological Polar Surface Area:109
Heavy Atom Count:18
Complexity:377
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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