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Cilastatin

Cilastatin structure

CAS No:
82009-34-5
Formula:
C16H26N2O5S
Chemical Name:
Cilastatin
Synonyms:
2-Heptenoic acid,7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-,(2Z)-;2-Heptenoic acid,7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-,[R-[R*,S*-(Z)]]-;(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid;Cilastatin;Cilastin
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Cilastatin is a dehydropeptidase inhibitor.

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Cilastatin Basic Attributes

Molecular Weight：

358.45

Exact Mass：

358.45

EC Number：

279-875-8

DSSTox ID：

DTXSID8048238

Characteristics

PSA：

155

XLogP3：

2.52380

Appearance：

Solid

Density：

1.275 g/cm3

Melting Point：

156-158°C

Boiling Point：

655.5°C at 760 mmHg

Flash Point：

350.2ºC

Refractive Index：

1.569

Water Solubility：

1.00e-01 g/L

Storage Conditions：

-20°C Freezer

Safety Information

wgk germany：

hazard class code：

R36/37/38:Irritating to eyes, respiratory system and skin .

safety instructions：

S26-S36

Marks：

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES). (See all compounds classified as Protease Inhibitors.)

MeSH Entry Terms：

Cilastatin

Cilastatin Use and Manufacturing

spectrum antibiotic

Computed Properties

Molecular Weight:358.5
XLogP3:-1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:358.15624311
Monoisotopic Mass:358.15624311
Topological Polar Surface Area:155
Heavy Atom Count:24
Complexity:519
Undefined Atom Stereocenter Count:2
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Potassium hydroxide

Related Drugs

Imipenem
Ingredients	This product is a compound preparation, whose components are imipenem (calculated as C12H17N3O4S) and cilastatin (calculated as C16H26N2O5S).
Indication	Not yet clear.

Imipenem
Ingredients	This product is a compound preparation, whose components are imipenem (calculated as C12H17N3O4S) and cilastatin (calculated as C16H26N2O5S).
Indication	Not yet clear.
Specifications	raw material
Manufacturer	Shandong Newtime Pharmaceutical Co., Ltd.

Imipenem
Ingredients	This product is a compound preparation, whose components are imipenem (calculated as C12H17N3O4S) and cilastatin (calculated as C16H26N2O5S).
Indication	Not yet clear.
Manufacturer	Zhejiang Hisun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

JW PHARMACEUTICAL CORP

United States
Active
Sun Pharmaceutical Industries Ltd

United States
Inactive

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Cilastatin cas82009-34-5

CAS No.: 82009-34-5

Grade: Pharmaceutical Grade

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