Benzothiazole

135.19

135.19

109468

202-396-2

G5BW2593EP

8040

DTXSID7024586

Yellow liquid

2934200090

41.1

2

Clear yellow-brown to brown Liquid

1.246 g/cm³ @ Temp: 20 °C

2 °C

227-228 °C @ Press: 765 Torr

>230 °F

1.689

H2O: slightly soluble

Refrigerator

34 mm Hg ( 131 °C)

4.66 (vs air)

Oral-rat LD50; 466 mg/kg; Oral-Mouse LD50: 900 mg/kg

Flammable; burning produces toxic nitrogen oxides, sulfur oxides and cyanide fumes

0.9-8.2%(V)

ODOR SIMILAR TO THAT OF QUINOLINE

134.7 Ų [M+Na]+

Ⅲ

6.1

2810

2

22-20/21/22-36-25-24-20

23-26-36-36/37-45

DL0875000

Xn,T,Xi

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Stable - regarded as highly persistent in the environment. Incompatible with strong oxidizing agents. Combustion products: nitrogen oxides, carbon monoxide, carbon dioxide, sulphur oxides.

P280-P301 + P310-P305 + P351 + P338-P312

H301 + H311-H319-H332

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

REACT WITH WATER, STEAM OR ACIDS TO PRODUCE TOXIC & FLAMMABLE VAPORS OF HYDROGEN SULFIDE. /SULFIDES/|ON CONTACT WITH ACID, ACID FUMES, WATER OR STEAM, THEY WILL PRODUCE TOXIC & FLAMMABLE VAPORS. /CYANIDES/

Drzyga O et al; Appl Environ Microbiol 62 (5): 1710-16 (1996). Cometabolic transformation and cleavage of nitrodiphenylamines by three newly isolated sulfate reducing bacterial strains.|Paxeus N; Water Res 30 (5): 1115-22 (1996). Organic pollutants in the effluents of large wastewater treatment plants in Sweden.|Puig A et al; J Chromatog 733 (1-2): 511-22 (1996). Wastewater from the manufacture of rubber vulcanization accelerators: Characterization, downstream monitoring and chemical treatment.|Scott BF et al; Water Qual Res J Canada 31 (2): 341-60 (1996). Determination of benzothiazole and alkylphosphates in water samples from the Great Lakes drainage basin.|For more Special Reports (Complete) data for BENZOTHIAZOLE (10 total), please visit the HSDB record page.

UN 2810

P280; P301 + P310; P305 + P351 + P338; P312

|Danger|H301 (87.45%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P337+P313, P361, P363, P405, and P501|Aggregated GHS information provided by 1658 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P262, P264, P270, P280, P301+P312, P302+P350, P305+P351+P338, P310, P322, P330, P332+P313, P337+P313, P361, P363, P405, and P501

ONE OF 2 TIRE PLANTS STUDIED FOR TRACE ORGANIC COMPDS IN WASTE WATERS RECYCLES ANTI-TACK SOLN & EMITS MOSTLY BENZOTHIAZOLE & 2-MERCAPTOBENZOTHIAZOLE.|Benzothiazole was detected in effluents of German incinerator plants at concentrations of about 3.1X10-7 g/cu m (1). Unspecified concentrations of benzothiazole were detected in pyrolytic oil waste streams in Winchester, Virginia following a fire at a tire storage facility(2). Unspecified concentrations of benzothiazole were detected in effluents from rubber vulcanization manufacturing facilities(3,4). Concentrations of 2 ppb were detected in wastewater streams in the vicinity of a specialty chemical manufacturing plant whose location was not specified(5). Benzothiazole was detected in tire manufacturing plant wastewater streams at unspecified locations at concentrations of 20-60 ppb(6).

highly toxic

Intravenous LD50 in mouse = 95 mg/kg

Benzothiazole's production and use as a synthetic reagent in organic chemistry(1) may result in its release to the environment through various waste streams(SRC). The degradation of fungicides containing 2-(thiocyanomethylthio)benzothiazole and the rubber vulcanization agent, 2-mercaptobenzothiazole results in the formation of benzothiazole(2).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 295(SRC), determined from an experimental log Kow(2,SRC) and a recommended regression-derived equation(3), indicates that benzothiazole will have moderate mobility in soil(SRC). Volatilization of benzothiazole will not be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 3.7X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Biodegradation of benzothiazole occurs rapidly under aerobic conditions. Employing a standard BOD dilution technique and an activated sludge inoculum, a theoretical BOD of 100% was observed for a 0.0125 mM sample of benzothiazole over an unspecified time period(5). Unspecified concentrations of benzothiazole were degraded by both mixed cultures and activated sludge mediums(6).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 295(SRC), determined from an experimental log Kow(2,SRC) and a recommended regression-derived equation(1), indicates that benzothiazole may adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces should be slow based upon an estimated Henry's law constant of 3.7X10-7 atm-cu m/mol (SRC), developed using a fragment constant estimation method(3). Estimated half-lives for a model river and model lake are 114 and 832 days, respectively(1,SRC). According to a classification scheme(4), an estimated BCF value of 20(1,SRC), from an experimental log Kow(2), suggests that bioconcentration in aquatic organisms is low(SRC). The biodegradation of benzothiazole occurs rapidly under aerobic conditions. Complete biodegradation of 72X10-6 mols/l of benzothiazole incorporated into an activated sludge medium obtained from a municipal wastewater treatment facility was observed after a period of 16 days(5).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzothiazole, which has an estimated vapor pressure of 0.014 mm Hg at 25 °C(2,SRC), will exist solely as a vapor in the ambient atmosphere. Benzothiazole is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 18 hours(3,SRC).

The rate constant for the vapor-phase reaction of benzothiazole with photochemically-produced hydroxyl radicals has been estimated as 7.0X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC).

7.59|An estimated BCF value of 20 was calculated for benzothiazole(SRC), using an experimental log Kow of 2.01(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of benzothiazole is estimated as approximately 295(SRC), using an experimental log Kow of 2.01(1,SRC) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that benzothiazole has moderate mobility in soil(SRC).

The Henry's Law constant for benzothiazole is estimated as 3.7 X 10-7 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This value indicates that benzothiazole will volatilize slowly from water surfaces(2,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 114 days(2,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 832 days(2,SRC). Benzothiazole's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces should be slow(SRC).

SURFACE WATER: Unspecified concentrations of benzothiazole were detected in street run off in San Francisco, California(1). Benzothiazole was detected in water samples from Rhine, Netherlands at concentrations of 2.0X10-8 g/l(2). Unspecified concentrations of benzothiazole were detected in the Manachal, Mausica and Caroni rivers in Trinidad(3).|DRINKING WATER: Unspecified concentrations of benzothiazole were detected in the drinking water of Cincinnati, Ohio(1) and Great Britain(2). Concentrations of 1.0X10-7 g/l to 5.0X10-7 g/l of benzothiazole were detected at unspecified locations in Canadian drinking water(3).

Quantities of benzothiazole were found in salt fermented anchovies and hair tail viscera shrimp at concentrations of 124 ng/g and 247 ng/g respectively(1). Unspecified amounts of benzothiazole were detected in samples of cassava roots from the Dominican Republic(2), nectarines from California(3), apples from Kogyoku, Japan(4) and volatiles of roasted filbert nuts(5).

BENZOTHIAZOLE WAS AMONG 15 COMPD IDENTIFIED BY GAS CHROMATOGRAPHY IN RUBBER VULCANIZATION AMBIENT AIR.|BENZOTHIAZOLE WAS AMONG CONTAMINANTS PRESENT IN RAW MATERIALS OR REACTION PRODUCTS EMITTED DURING CURING OF TREAD RUBBER CONTAINING SBR & CIS-POLYBUTADIENE UNDER SIMULATED VULCANIZATION CONDITIONS.|Occupational exposure to benzothiazole through inhalation or dermal contact may occur at rubber processing facilities(1,2). The general population will be exposed to benzothiazole through the ingestion of contaminated food sources or drinking water(SRC).

0.14 Days

benzothiazole

All other basic organic chemical manufacturing|Benzothiazole: ACTIVE|REPORTED USES: NON-ALCOHOLIC BEVERAGES, CANDY, BAKED GOODS, MEAT, MEAT SAUCES, SOUPS, MILK, DAIRY PRODUCTS ALL 0.5 PPM. /FROM TABLE/|BENZOTHIAZOLE IS USED TO PREVENT MICROBIAL GROWTH IN SHOES & ATHLETES FOOT DEVELOPMENT. POROUS INSOLES ARE IMPREGNATED WITH SOLN CONTAINING BENZOTHIAZOLE.|...IN...COCOA, SHALLOW-FRIED BEEF, SOYBEAN MILK, STORED CASEIN, HEATED MILK, STALE NON-FAT DRY MILK, & STERILIZED CONCENTRATED MILK...ONLY THIAZOLE DERIV REPORTED WAS BENZOTHIAZOLE.|...BENZOTHIAZOLE /WAS REPORTED/ TO BE PRESENT IN BEER.|For more General Manufacturing Information (Complete) data for BENZOTHIAZOLE (8 total), please visit the HSDB record page.

GAS CHROMATOGRAPHIC METHOD FOR CONCN & ANALYSIS OF TRACES OF INDUSTRIAL ORG POLLUTANTS IN ENVIRON AIR & STACKS. BENZOTHIAZOLE AMONG COMPD ANALYZED.|GC and GC-MS methods to detect benzothiazoles in an aquatic environment.|Louter AJH et al; J Chromat 725 (1): 67-83 (1996). Analysis of microcontaminants in aqueous samples by fully automated online phase extraction gas chromatography mass selective design.|Kienhius PGM; J Chromatog 647 (1): 39-50 (1993). Radio frequency only daughter scan mode to provide more spectral information in liquid chromatography thermospray tandem mass spectrometry.

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