N-Methylaniline

107.15

107.15

202-870-9

TH45GK410O

0921

3502

2294

DTXSID9021841

COLORLESS OR SLIGHTLY YELLOW LIQ|Yellow to light brown liquid.

29214200

12

1.7

N-methylaniline appears as a colorless to brown viscous liquid. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

0.989 g/cm³ @ Temp: 20 °C

-57 °C

196.25 °C

174 °F

n 20/D 1.571(lit.)

water: slightly soluble 30g/L

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

0.5 hPa (20 °C)

3.9

LD in rabbits (g/kg): 0.28 orally; in rabbits, cats (mg/kg): 24, 24 i.v. (Treon)

Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

Weak, ammonia-like odor.

8.88e-06 atm-m3/mole

pKa = 4.848 @ 25 °C

Standard Heat of fusion @ 25 °C: 7.7 kcal/mol /liquid/; 20.4 kcal/mol /gas/|Dielectric constant: 6.06 @ 25 °C|Becomes brown on exposure to air.

Becomes brown on exposure to air (NTP, 1992). Slightly soluble in water.

Amines, Aromatic

N-METHYLANILINE is an aryl an amine. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

-973.5 kcal/mol @ 25 °C /Liquid/

7.32 eV

Class IIIA Combustible Liquid: Fl.P. at or above 140°F and below 200°F.

12.7 kcal/mol @ 25 °C

Critical temperature = 428 °C; Critical pressure = 51.3 atm

III

6.1

UN2294 N-Methylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.UN 2294 6.1/PG 3

3

23/24/25-33-50/53

28-36/37-45-60-61-28A

BY4550000

T,N

Separated from strong oxidants, strong acids and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.

Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.

P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, P501

H301

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

CAN REACT WITH OXIDIZING MATERIALS|Strong acids, strong oxidizers.

Special Hazards of Combustion Products: Toxic vapors are generated when heated. (USCG, 1999)|Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Above 79.5 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P391, P403+P233, P405, and P501|H301 (99.12%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P311, P312, P314, P321, P322, P330, P337+P313, P361, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 456 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P260, P264, P270, P273, P280, P301+P312, P307+P311, P309+P311, P314, P321, P330, P370+P378, P391, P403+P235, P405, and P501|P210, P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P307+P311, P309+P311, P312, P314, P321, P330, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)|Use water spray, powder, foam, carbon dioxide.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Recommendations for respirator selection. Max concn for use: 5 ppm. Respirator Class(es): Any supplied-air respirator.|Recommendations for respirator selection. Max concn for use: 12.5 ppm. Respirator Class(es): Any supplied-air respirator operated in a continuous flow mode.|For more Personal Protective Equipment (PPE) (Complete) data for N-METHYLANILINE (8 total), please visit the HSDB record page.|(See protection codes)

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed and replaced.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas.|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for N-METHYLANILINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 2 ppm (9 mg/cu m). Skin Designation.|Vacated 1989 OSHA PEL TWA 0.5 ppm (2 mg/cu m), skin designation, is still enforced in some states.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 0.5 ppm (2 mg/cu m), skin.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Separated from strong oxidants, strong acids and food and feedstuffs. Keep in a well-ventilated room. Store in an area without drain or sewer access.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.

NO open flames. Above 79.5 °C use a closed system and ventilation.

PREVENT GENERATION OF MISTS! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

In a comprehensive survey of wastewater from 4000 industrial and publicly owned treatment works (POTWs) sponsored by the Effluent Guidelines Division of the U.S. EPA, N-methylaniline was identified in discharges of the following industrial category (positive occurrences, median concn in ppb): petroleum refining (1; 161.3), printing and publishing (1; 9.8), pharmaceuticals (2; 1022), foundries (1; 2.2), aluminum (1; 6.1), organic chemicals (5; 18.5), publicly owned treatment works (2; 39.8)(1). The highest effluent concn was 1736 ppb in the pharmaceuticals industry(1). N-Methylaniline was detected in the effluent of one of three New Jersey publicly-owned treatment works (POTWs) at 13-17 ppb(2). It was detected, but not quantified, in wastewater from the Kashima petrochemical complex (includes organic chemicals factory) in Japan(3). Sludge from the Muskegon County (MI) Wastewater Treatment System contained 310 ppb of N-methylaniline which was applied to land(4).

In 1988, N-methylaniline was qualitatively identified in air at a forest site in West Germany, studied because of severe damage to spruce trees over the previous decade(1).

N-Methylaniline was not detected in cigarette smoke concentrate, although it was detected in a previous study(1).

MONOMETHYL ANILINE (1.95 G/KG OF FOOD) & SODIUM NITRITE (1.0 G/L WATER) FED TO MICE CAUSED LUNG ADENOMAS & MALIGNANT LYMPHOMAS.

N-Methylaniline is produced in nature, being found in fresh vegetables, such as spinach, red cabbage, carrots, and celery(1), and fruits, such as orange rind(2).

N-Methylaniline may be released to the environment(SRC) as a result of its manufacture, transport, disposal and use as a chemical intermediate and solvent(1). N-Methylaniline has been identified in the waste stream of incinerators and may be emitted from such facilities(2). Similarly, it is found in condensate from coal gasification plants and may released with the tar wastes or emissions from such plants(3).

TERRESTRIAL FATE: N-Methylaniline has low adsorptivity to soil(2) and if released on soil may leach, especially in sandy soil. It may photodegrade on the soil surface(3). Some N-methylaniline may also volatilize from the soil surface. When N-methylaniline was applied to land in sludge and the sludge allowed to dry and then tilled into the soil to a depth 6 inches within 5 days, N-methylaniline degraded fairly rapidly(1). The avg concn of N-methylaniline over 3 plots in 0-6 inch cores was 511, 138, and 16 ppb, 5, 122 and 241 days after sludge application, respectively. While 82 ppb of N-methylaniline was found in 9-15 inch cores, 5 days after application, none was found at later sampling dates. While N-methylaniline biodegrades in screening studies and may therefore be expected to biodegrade in soil, it is also known to slowly react with humic material in soil(4). It is easily oxidized(5) and may react with natural oxidants in soil(SRC).|AQUATIC FATE: The Henry's Law constant is estimated to be 1.14X10-5 atm-cu m/mol(SRC), from its vapor pressure, 0.453 mm Hg(1), and water solubility, 5624 mg/L(2). Using this Henry's Law constant, its half-life in a model river and model lake is estimated to be 3.5 and 28 days, respectively(3,SRC). N-Methylaniline is sensitive to photooxidation and may photodegrade in surface water(4). It is sensitive to oxidation(5) and may be oxidized by naturally-occurring oxidants in the water body(SRC). N-Methylaniline has a low Koc(6) and BCF(7) would not be expected to adsorb to sediment or bioconcentrate in fish(SRC).|ATMOSPHERIC FATE: According to its vapor pressure, 0.453 mm Hg at 25 °C(2), N-methylaniline should exist in the atmosphere as a vapor(4). It will react with photochemically-produced hydroxyl radicals with an estimated half-life of 8.8 hr(3,SRC). It may also photolyze or oxidize while in the vapor phase or in aerosols. The rates of vapor phase photolysis are unknown. N-Methylaniline is fairly soluble in water, 5624 mg/L(1), and therefore should be scavenged by rain(SRC).

The pKa for N-methylaniline is 4.848 at 25 °C(1) indicating that some of the molecule is ionized (e.g, 10% at pH 5.8) at the acidic end of the environmental pH range. N-Methylaniline is susceptible to oxidation and photooxidation in solution(3,4) as is evidenced by its turning brown on exposure to air(3). Algae-induced phototransformations of anilines is believed to involve superoxide ions(5). In a laboratory study, the half-life of N-methylaniline in a photoreactor illuminated with 20 W fluorochemical lamps (radiation between 300 and 400 nm with a maximum at 350 nm) was 1.5 hr(2).|N-Methylaniline has a vapor pressure of 0.453 mm Hg at 25 degC(3) and therefore in the atmosphere, it will exist primarily as the vapor(2). In the atmosphere, vapor-phase N-methylaniline reacts with photochemically-produced hydroxyl radicals with an estimated rate constant of 43.9X10-12 cu cm/molecule-s(1). Assuming a hydroxyl radical concn of 5X10+5 radicals/cu cm, the half-life of N-methylaniline in the atmosphere would be 8.8 hr(SRC). The structurally similar chemical, aniline, has a strong UV absorption band at 285 nm which extends beyond 290 nm(4) and therefore N-methylaniline which would be expected to have similar UV absorption and could be subject to direct photolysis.

10.00|N-Methylaniline was found to have very low bioconcentration in fish using the procedures of the Ministry of International Trade and Industry (MITI) in Japan(1,2). Using its log Kow of 1.66(3), one would estimate a BCF of 11 for N-methylaniline using a recommended regression equation(4). This would indicate that N-methylaniline would not bioconcentrate in aquatic organisms(SRC).

190.55 L/kg|Since the pKa of N-methylaniline is 4.848(2), N-methylaniline will be partially ionized at acidic environmental pHs and its adsorption to soil would be expected to be pH-dependent(SRC). The Koc for N-methylaniline predicted from molecular structure is 65(3). According to a suggested classification scheme(5), this estimated Koc suggests that N- methylaniline will be highly mobile in soil(SRC). Batch equilibrium studies used to determine the adsorption isotherms for N-methylaniline to a Podzol (4.85% OC pH 2.8), an Alfisol (1.25% OC, pH 6.7) and a sediment (1.58% OC, pH 7.1) yielded the results (soil, Freundlich adsorption constants (Kf), Freundlich exponent (1/n), Koc): Podzol, 22.29, 0.89, 460; Alfisol, 0.59, 0.78, 47; Sediment, 1.12, 0.77, 71(1). N-Methylaniline will be almost completely ionized at the pH of the Podzol and therefore ionic interactions may be dominant(1,SRC). N-Methylaniline reacts slowly with humates possibly by adding to quinoidal structures in the humic substances(4). Covalent bond formation is inferred by the lack of extractability of the aniline from the humic material as well as reactions with model compounds(4).

The Henry's Law constant for N-methylaniline estimated from its vapor pressure, 0.453 mm Hg(1), and water solubility, 5624 mg/L(2), is 1.14X10-5 atm-cu-m/mol(SRC). Using this value for the Henry's Law constant, one can estimate a volatilization half-life of 3.5 days for N-methylaniline in a model river 1 m deep flowing at 1 m/s with a wind speed of 3 m/s(3). Similarly, the volatilization half-life for N-methylaniline from a model lake 1 m deep, with a 0.05 m/s current and a 0.5 m/s wind is estimated to be 28 days(3).

SURFACE WATER: N-Methylaniline was found in the River Elbe and River Ammersbek at 0.8 and 1.1 ppb, respectively(1). A 1989 monitoring study of five sites in the Rhine delta in The Netherlands found N-methylaniline at one site on the main stream at 0.027 ug/L(2).

Samples of fresh vegetables containing N-methylaniline include (vegetable, concn): spinach, 3.4 ppm; red cabbage, 0.3 ppm; carrots, 0.8 ppm; celery, 0.5 ppm(1). No N-methylaniline was found in cabbage, cauliflower, kale, white beet, swede, red beet, large radish and red radish(1). Samples of pickled vegetables containing N-methylaniline include (vegetable, concn): paprika, 13.1 ppm; cucumber, 13.8 ppm; cucumber with mustard, 6.1 ppm; onion, 6.8 ppm; celery, 7 ppm(1). Tilsiter cheese and brown bread contained 37.9 and 0.7 ppm of N-methylaniline, but the chemical was not found in various forms of herring, cod roe and camembert and limburger cheese(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 82 workers are exposed to N-methylaniline in the USA(1). Workers would be exposed to N-methylaniline by inhalation and dermal contact(SRC). The general population will be exposed to N-methylaniline primarily through the consumption of vegetables naturally containing this chemical(SRC).

N-METHYLANILINE IS DISTRIBUTED IN THE LIVER, KIDNEY, LUNG, SMALL INTESTINE, BRAIN, & BLADDER TISSUE.

N-METHYLANILINE YIELDS ANILINE IN RABBIT; IN RAT. IT YIELDS P-METHYLAMINOPHENOL IN RABBIT. /FROM TABLE/|N-METHYLANILINE YIELDS N,N-DIMETHYLANILINE IN MYCOBACTERIUM. /FROM TABLE/|THE METABOLISM OF N-METHYLANILINE WAS STUDIED IN VITRO IN SEVERAL TISSUES OF THE IMMATURE HUMAN FETUS AND IN THE HUMAN PLACENTA. THE HIGHEST METABOLIZING ACTIVITY WAS OBSERVED IN THE LIVER. COMPARED TO ADULT RAT LIVER THE RANGE OF HEPATIC METABOLIC ACTIVITY VARIED FROM 5 TO APPROX 50% IN SOME FETUSES FOR N-METHYLANILINE DEMETHYLASE. ADRENAL GLAND HOMOGENATES HAD MEASURABLE N-METHYLANILINE METABOLIZING ACTIVITIES. IN THE GI TRACT, BRAIN, KIDNEYS, AND LUNGS THERE WAS NEGLIGIBLE OR NO ACTIVITY. IN ONE OF FIVE PLACENTAS STUDIED, ENZYME ACTIVITY COMPARABLE TO THAT IN THE LIVER WAS DETECTED. COFACTOR REQUIREMENTS OF THIS ENZYME INDICATED THAT IT WAS A DRUG-METABOLIZING MIXED-FUNCTION OXIDASE. IT WAS INHIBITED IN VITRO BY COMPOUNDS KNOWN TO BE SUBSTRATES OF LIVER MICROSOMAL DRUG METABOLIZING ENZYMES. THE LEVEL OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY IN THE FETAL LIVER WAS THE SAME OR HIGHER THAN IN ADULT RAT OR HUMAN LIVER.|N-Methylaniline is a known human metabolite of N,N-Dimethylaniline.

0.13 Days

Inhalation causes dizziness and headache. Ingestion causes blush discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

SYMPTOMATOLOGY: 1. GRAYISH BLUE CYANOSIS... 2. ...HEADACHE, NAUSEA, SOMETIMES VOMITING, DRYNESS OF THROAT. 3. CENTRAL NERVOUS SYMPTOMS: CONFUSION, ATAXIA, VERTIGO, TINNITUS, WEAKNESS, DISORIENTATION, LETHARGY, DROWSINESS, &...COMA. CONVULSIONS MAY OCCUR... /ANILINE/|SYMPTOMATOLOGY: 4. CARDIAC EFFECTS: HEART BLOCKS, ARRHYTHMIAS & SHOCK. 5. DEATH, ALTHOUGH UNCOMMON, IS USUALLY DUE TO CARDIOVASCULAR COLLAPSE & RESP PARALYSIS. 6. URINARY SIGNS...INCL PAINFUL MICTURITION, HEMATURIA, HEMOGLOBINURIA (& METHEMOGLOBINURIA), OLIGURIA, & RENAL INSUFFICIENCY... /ANILINE/|HAZARD: TOXIC BY INGESTION, INHALATION & SKIN ABSORPTION.|There are no reports of human intoxication from exposure to N-methyl aniline; however, the clinical toxicology of N-methyl aniline is expected to resemble that seen in cases of aniline poisoning. Overexposure would be expected to induce methemoglobinemia with signs of cyanosis (especially in the lips, nose, and earlobes) weakness, dizziness, and severe headache. Further, based on the fact that aniline can cross the placenta and induce fetal methemoglobinemia, a similar property can be expected in the case of N-methyl aniline.

methylaniline

The substance can be absorbed into the body by inhalation of its vapour, by inhalation of its aerosol, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

lassitude (weakness, exhaustion), dizziness, headache; dyspnea (breathing difficulty), cyanosis; methemoglobinemia; pulmonary edema; liver, kidney damage

Blue lips, fingernails and skin. Cough. Dizziness. Headache. Laboured breathing. Sore throat.

MAY BE ABSORBED! Further see Inhalation.

respiratory system, liver, kidneys, blood, central nervous system

Technical

All other petroleum and coal products manufacturing|Benzenamine, N-methyl-: ACTIVE

ANALYTE: MONOMETHYL ANILINE, MATRIX: AIR, PROCEDURE: BUBBLER COLLECTION IN DILUTE SULFURIC ACID, GC ANALYSIS OF THE COLLECTED SAMPLES AFTER BASIFICATION WITH SODIUM HYDROXIDE. RANGE: 4.38-17.52 MG/CU M.|ANILINE DETECTION AND ANALYSIS BY THIN LAYER CHROMATOGRAPHY.|40 PRIMARY & SECONDARY AMINES WITH DIFFERENT GAS-CHROMATOGRAPHIC PROPERTIES DETECTED IN FOOD ITEMS, ANIMAL FEEDSTUFFS & SURFACE WATER, & 21 WERE IDENTIFIED BY MASS SPECTROMETRY.|NIOSH Method #3511, Monomethylaniline, Issued 8/15/94. Gas chromatography with FID, range 0.1-3 mg/sample, estimated limit of detection 8 ug/sample.|NIOSH Method #S153, Monomethylaniline, Issued 8/15/90. Gas chromatography with FID, range 4.38-17.52 mg/cu m, limit of detection not determined.

Fire Hazards -> Flammable - 2nd degree