2-Amino-1-butanol
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2-Amino-1-butanol
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CAS No:
96-20-8
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Formula:
C4H11NO
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Chemical Name:
2-Amino-1-butanol
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Synonyms:
1-Butanol,2-amino-;2-Amino-1-butanol;1-(Hydroxymethyl)propylamine;1-Hydroxy-2-butylamine;2-Amino-1-hydroxybutane;2-Aminobutyl alcohol;1-Hydroxy-sec-butylamine;1-Hydroxy-2-aminobutane;DL-α-Aminobutanol;DL-2-Aminobutanol;dl-2-Amino-1-butanol;(±)-2-Amino-1-butanol;DL-2-Amino-1-butanol;(RS)-2-Amino-1-butanol;NSC 1068;1-Hydroxybutan-2-amine;13054-87-0
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CAS No:
Characteristics
46.2
-0.43
Clear Liquid
0.9443 g/cm3 @ Temp: 26 °C
-2 °C
178 °C
184 °F
1.446
Store below +30°C.
Oral-mouse LD50: 2300 mg/kg; peritoneal-mouse LDL0: 250 mg/kg
Near fire, flammable in case of heat and oxidant; burning produces toxic nitrogen oxide fumes
Safety Information
III
8
UN 2735 8/PG 3
2
34-50-22
26-36/37/39-45-61
EK9625000
C
Warehouse ventilated, low temperature and dry
P273-P280-P305 + P351 + P338-P310
H302-H314-H400
|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P332+P313, P337+P313, P362, P363, P391, P405, and P501|Aggregated GHS information provided by 144 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P280, P281, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P321, P330, P363, P405, and P501
2-Amino-1-butanol Use and Manufacturing
It is obtained by the chlorination addition reaction of butene-1 with acetonitrile and chlorine gas, followed by hydrolysis, alcoholization and alkalization. Except for the alkalization operation, the process is continuously carried out in the pipeline device in the following order. The purity of butene-1 is 50-80%. The molar ratio of the chlorination reaction is butene-1:chlorine:acetonitrile=1:0.85:7-8, the reaction temperature is 40-50°C, and the feed flow rate is 2.5-3.0kg/h. After the chlorination reaction is completed, the acetonitrile and dichlorobutane in the reaction are recovered by distillation in an acetonitrile recovery tower. Then the alcoholysis reaction is carried out. The distilled reaction liquid is added to hydrochloric acid and ethanol equivalent to the weight of butene-1, and fed at atmospheric pressure. The temperature at the bottom of the tower is 104℃, and the temperature at the top of the tower is 72-75℃. A mixture of ethyl acetate, water and ethanol is produced. The alcoholysis reaction solution is alkalized by sodium hydroxide and distilled to obtain crude 2-aminobutanol. Finally, a product with a content of more than 95% is obtained by vacuum fractionation.
Used to prepare emulsifiers, surfactants and vulcanization accelerators, organic synthesis, acid gas absorbent. After separation, (+) 2-aminobutanol is used for the production of anti-tuberculosis drug ethambutol.
Processing aids, not otherwise listed
25,000 - 100,000 lb
Industrial gas manufacturing|1-Butanol, 2-amino-: ACTIVE
Cosmetics -> Buffering
Computed Properties
Molecular Weight:89.14
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:89.084063974
Monoisotopic Mass:89.084063974
Topological Polar Surface Area:46.2
Heavy Atom Count:6
Complexity:30.7
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
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Undecanoic acid, compd. with 2-amino-1-butanol (1:1)
94138-73-5
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2-Propenoic acid, 3-phenyl-, compd. with 2-amino-1-butanol (1:1)
94086-73-4
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Trisodium phosphate
7601-54-9
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Diammonium hydrogen phosphate Formula
7783-28-0
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Calcium hydroxide Formula
1305-62-0
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2-Phosphonobutane-1,2,4-tricarboxylic acid Formula
37971-36-1
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Sodium acetate Structure
127-09-3
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Hydrogen bromide Structure
10035-10-6
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What is Diethylethanolamine
100-37-8
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What is Boric acid (H3BO3)
10043-35-3