Diethylethanolamine

117.18900

117.19

202-845-2

S6DL4M053U

0257

8759

2686

DTXSID5021837

COLORLESS LIQUID|Colorless liquid.

2922192210

23.47000

0.32050

2-diethylaminoethanol appears as a colorless liquid. Flash point 103-140°F. Less dense than water . Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Causes burns to the skin, eyes and mucous membranes.

0.8921 g/cm³ @ Temp: 20 °C

-70 °C

163 °C @ Press: 760 Torr

51.5ºC

1.44-1.442

H2O: soluble

Flammables area

1 mm Hg ( 20 °C)

4.04 (vs air)

Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

vol% in air: 1.98

NAUSEATING ODOR

pKa = 9.87 at 20 °C (conjugate acid)

HYGROSCOPIC LIQUID BASE COMBINING THE PROPERTIES OF AMINES & ALC; WT/GAL: 7.14 LB @ 20 °C|Cubic expansion coefficient = 1.07x10-3 1/K|Specific heat = 2.42 kJ/kg-K|Specific electrical conductivity = 1.1x10-3 1/ohm-cm|vapor pressure = 1.4 mm Hg @ 25 °C

Flammable. Soluble in water. This chemical is sensitive to moisture. Slowly hydrolyzes.

Alcohols and Polyols

2-DIETHYLAMINOETHANOL is an organic compound with both amine and alcohol substituents. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. This compound can react with strong oxidizers and acids. (NTP, 1992)

608 °F (320 °C)|250 °C

Flammable limits in air, % by volume: Lower: 6.7; Upper: 11.7.|Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.

383.9 kJ/kg

II

8

UN 2686

1

R10; R20/21/22; R34

S25-S26-S36/37/39-S45

KK5075000

C

Fireproof. Separated from strong oxidants and strong acids. Cool. Dry.

Stable. Flammable. Incompatible with strong oxidizing agents, acids. Moisture sensitive. Hygroscopic.

P210-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P370 + P378

H226-H302-H311 + H331-H314

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Drain into the sewer with abundant water. (a) Dissolve in a combustible solvent such as alcohols, etc. Burn in an open furnace by igniting from a safe distance with the utmost care or sprinkle into the fire chamber of the furnace with afterburner and scrubber. (b) Pour into sodium bisulfate in a large evaporating dish. Sprinkle water and neutralize. Drain into the sewer with sufficient water.

Strong oxidizers, strong acids.

Special Hazards of Combustion Products: Toxic and irritating gases may be generated. Behavior in Fire: Can react with oxidizing materials. (USCG, 1999)|Flammable. Gives off irritating or toxic fumes (or gases) in a fire. Above 52 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree

|Danger|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P370+P378, P403+P235, P405, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P234, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P361, P363, P370+P378, P390, P403+P233, P403+P235, P404, P405, and P501|Aggregated GHS information provided by 1217 companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P312, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P307+P311, P310, P311, P312, P314, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb with earth, sand or other non-combustible material and transfer to containers (except for Hydrazine). Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet or significantly contaminated should be removed and replaced. Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. Provide: Eyewash fountains should be provided (when concentration is >5%) in areas where there is any possibility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2016)|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|Eyewash fountains should be provided in areas where there is any possbility that workers could be exposed to the substance; this is irrespective of the recommendation involving the wearing of eye protection. /liquids containing >5% of contaminant/|Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.]|For more Personal Protective Equipment (PPE) (Complete) data for DIETHYLAMINOETHANOL (9 total), please visit the HSDB record page.|(See protection codes)

Flammable; moderate fire hazard

Explosive limits , vol% in air: 1.9-28

Wear goggles, self-contained breathing apparatus and rubber overclothing (including gloves).|If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical.

Overspread sufficient sodium bisulfate and sprinkle water. Drain into the sewer with abundant water.|1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected and atomized in a suitable combustion chamber equipped with an appropriate effluent gas cleaning device. Diethylaminoethanol should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion. Sewers designed to preclude the formation of explosive concentrations of diethylaminoethanol vapors are permitted.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet or significantly contaminated should be removed or replaced.|If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Build dikes to contain flow as necessary. Use water spray to knock-down vapors.|For more Preventive Measures (Complete) data for DIETHYLAMINOETHANOL (6 total), please visit the HSDB record page.

/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Fire or Explosion: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Health: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 132: FLAMMABLE LIQUIDS - CORROSIVE/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for DIETHYLAMINOETHANOL (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Diethylaminoethanol vapor is a skin, eye, and respiratory irritant.

Permissible Exposure Limit: Table Z-1 8-hr Time-Weighted Avg: 10 ppm (50 mg/cu m). Skin Designation.

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 10 ppm (50 mg/cu m), skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Fireproof. Separated from strong oxidants and strong acids. Cool. Dry.

A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20 °C.

The substance is corrosive to the eyes. The substance is severely irritating to the skin and respiratory tract. The substance may cause effects on the nervous system.

NO open flames, NO sparks and NO smoking. Above 52 °C use a closed system and ventilation.

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

LD50 Rabbit skin 1,260 mg/kg|LD50 Guinea pig skin 1,000 mg/kg|LD50 Rat oral 1,300 mg/kg|LD50 Rat ip 1,220 mg/kg|For more Non-Human Toxicity Values (Complete) data for DIETHYLAMINOETHANOL (7 total), please visit the HSDB record page.

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of diethylaminoethanol might cause exacerbation of symptoms due to its irritant properties. ... Persons with pre-existing skin disorders may be more susceptible to the effects of this agent. ... Those with pre-existing eye problems may be at increased risk from exposure.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

ORALLY ADMIN TO RATS, WAS MAINLY EXCRETED VIA KIDNEYS. ELIMINATED WITHIN FIRST 24 HR. AFTER 48 HR EXCRETED INDEPENDENTLY OF DOSE. AFTER 40 DAYS STILL BEING ELIMINATED. UP TO 60% ACCUMULATED IN LIVER. CNS & SPINAL CORD SHOWED HIGHEST CONCN AFTER 7 DAYS.|The absorption of 2-diethylaminoethanol (administered orally as 2-diethylaminoethanol acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min. The biological half-life is 3.5 hr with 39% of the excreted product appearing in the urine after 48 hr.

CHRONIC ORAL ADMIN ... TO RATS RESULTS IN LIVER ACCUM OF UP TO 60% OF THE DRUG. ... METABOLITES PRODUCED WERE DIETHYLAMINOETHANOL N-OXIDE, DIETHYLAMINOACETIC ACID & ETHYLAMINOETHANOL ... .

The biological half-life is 3.5 hr ... .

INHALATION: Irritation of mucous membranes. EYES: Corrosive, causes intense pain. SKIN: Severe irritation. May cause allergic skin reaction. INGESTION: Gastrointestinal irritation. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/Diethylaminoethanol/ can also produce nausea and vomiting.|An attempt by a laboratory worker to remove animals from an inhalation chamber containing approx 100 ppm resulted in nausea and vomiting within 5 min after a fleeting exposure; no irritation of the eyes or throat was noted during this brief exposure. Other persons in the same room also complained of a nauseating odor but showed no ill effects.|Environmental samples were analyzed for diethylaminoethanol at the Johnson Museum, Cornell University, Ithaca, New York in January 1983. The survey was requested by the 40 employees because of eye irritation and dermatitis. Diethylaminoethanol was used to humidify the air in the museum. Air samples and bulk samples were analyzed for diethylaminoethanol. Medical interviews were conducted. Of the 14 samples taken, only 2 had detectable amounts of diethylaminoethanol. The two concentrations were 0.05 and 0.04 mg/cu m. This was below the OSHA standard of 50 mg/cu m. The two bulk samples contained about 30 mg per square meter of exposed area. A total of 46% of the employees complained of eye irritation, 37% complained of skin irritation, and 17% complained of headache, nose and throat irritation, or dizziness. Six females reported gynecological problems. /It was/ concluded that contact with surfaces coated with condensed diethylaminoethanol may be responsible for some of the irritant effects. It is recommended that diethylaminoethanol be wiped from surfaces, or the use of diethylaminoethanol be discontinued.|In response to a request from a management representative an evaluation was made of an outbreak of illness at a /electronics manufacturing plant/ located in Cincinnati, Ohio. The company manufactured electrical circuit boards and electrical equipment for the commercial and defense industries. In September of 1988 two boilers were prepared for operation by adding corrosion inhibitinq chemicals, diethylaminoethanol and cyclohexylamine. Steam produced by the boilers was used for humidity in the work area. Symptoms consistent with acute toxic effects of diethylaminoethanol and cyclohexylamine were noted in 65 of the employees. These included nausea, dizziness, vomiting, and eye, nose, and throat irritation. A significantly higher risk of having several symptoms was noted among the employees in the areas humidified with boiler steam than among employees in the nonboiler steam humidified areas. Employee exposures to metals from solder fumes and methyl-ethyl-ketone were all below established-limits. There was friable asbestos insulation exposed on one boiler. /It was/ concluded that the exposures to the two corrosion inhibiting chemica1s were responsible for the workers' symptoms.|On March 23, 1981, the National Institute for Occupational Safety and Health (NIOSH) received a request for a Health Hazard Evaluation from Boehring Ingelheim, Ltd, Ridgefield, Connecticut. The request stated that approximately 15 employees in the office support area of a production building had been experiencing rashes since the beginning of March 1981. Environmental samplinq did not reveal any diethylaminoethanol in air samples. However, results of sampling suggested the presence of a conjugated amine which possesses acidic properties. The specific agent could not be identified. Skin examinations revealed an irritant-type rash on the exposed areas of the face neck and hands. The distribution of the rash was consistent with and suggestive of a phototoxic skin reaction. Both the environmental and medical evaluations indicated the source of the dermatitis to be the air-handling system. However, no specific etiologic agent has been identified. The information in the body of the fu11 report suggests that a condensation or reaction product of diethylaminoethanol was likely responsible for the reported symptoms.

2-(diethylamino)ethanol

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.|inhalation, skin absorption, ingestion, skin and/or eye contact

irritation eyes, skin, respiratory system; nausea, vomiting

Cough. Nausea. Sore throat. Vomiting. Dizziness.

MAY BE ABSORBED! Redness. Pain.

Redness. Pain. Blurred vision.

Eyes, skin, respiratory system

Annual worldwide demand is more than 1,000 tons

National Starch and Chemical Liquid Grade|GRADE: TECHNICAL|Specification: 99% min purity

All other basic organic chemical manufacturing|Ethanol, 2-(diethylamino)-: ACTIVE

Method No. 200 Aminoethanol compounds. Gas chromatography (GC) working range: 5-300 mg/m3 in a 20-L air sample

DIETHYLAMINOETHANOL WAS SEPARATED FROM HUMAN URINE BY PAPER ELECTROPHORESIS & THIN-LAYER CHROMATOGRAPHY, & ISOLATES WERE DETERMINED SPECTROPHOTOMETRICALLY.

Fire Hazards -> Flammable - 2nd degree