2-Methyl-5-nitroaniline

152.15

152.15

879021

202-765-8

433MYH2DWM

8947

2660

DTXSID4020959

Yellow monoclinic prisms

2921430090

71.8

1.87

Ochre to yellow-orange Crystalline Powder

1.365 deg 15 C/deg 4 C

107-108 °C

329.4±22.0 °C at 760 mmHg

153.0±22.3 °C

1.616

H2O: <0.1 g/100 mL at 19 ºC

2-8°C

9.8X10-4 mm Hg at 25 deg C (est)

Reference value: Oral-rat LD50: 6860 mg/kg

Open flame flammable; liberates toxic aniline and nitrogen oxide gas when exposed to heat

Henry's Law constant = 8.3X10-9 atm-cu m/mole at 25 deg (est)

pKa = 2.345 (conjugate acid)

Hydroxyl radical rate constant: 1.2X10-11 cu cm/molecule sec at 25 °C (est)

Insoluble in water. This compound is sensitive to moisture, light, or prolonged exposure to air.

Nitro, Nitroso, Nitrate, and Nitrite Compounds, Organic

5-NITRO-O-TOLUIDINE is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates. (NTP, 1992)

III

6.1

UN 2660 6.1/PG 3

3

23/24/25-40-52/53

36/37-45-61

XU8225000

T,Xi

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Irritant

Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, acids, chloroformates.

P261-P273-P280-P301 + P310-P311

H301-H311-H331-H351-H412

[40 CFR 240-280, 300-306, 702-799 (7/1/2006)] Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U181, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaiminant (>/= 100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.|A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. A potential candidate for fluidized bed incineration at a temperature range of 450 to 980 °C and residence times of seconds for liquids and gases, and longer for solids.

Oxidizers, strong acids, acid chlorides, acid anhydrides, chloroformates.

USEPA; Health and Environmental Effects Profile for 2-Methyl-5-nitroaniline EPA/600/X-87/091 (1989).|Bioassay of 5-Nitro-o-toluidine for Possible Carcinogenicity (1978) Technical Rpt Series No. 107 DHEW Pub No. (NIH) 78-1357, U.S. Department of Health Education and Welfare, National Cancer Institute, Bethesda, MD 20014

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P273, P280, P281, P301+P310, P302+P352, P304+P340, P308+P313, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 112 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]|P201, P202, P260, P264, P270, P273, P281, P307+P311, P308+P313, P321, P405, and P501|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P405, and P501|H351: Suspected of causing cancer [Warning Carcinogenicity]|P201, P202, P260, P264, P270, P281, P308+P313, P314, P405, and P501|P201, P202, P260, P264, P270, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P405, and P501

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)|Where the potential for exposure to this chemical, use a MSHA/NIOSH approved supplied-air-respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self-contained breathing apparatus operated in a pressure-demand or other positive-pressure mode).

This chemical may burn but does not easily ignite. Use dry chemical, carbon dioxide, water spray, or alcohol or polymer foam extinguishers. Poisonous gases including nitrogen oxides are produced in fire. If materials or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped.

Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Use HEPA vacuum or wet method to reduce dust during clean-up. Do not dry sweep. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area of spill or leak after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation. All protective clothing (suits, gloves, footwear, headgear) should be clean, available each day, and put on before work. Contact lenses should not be worn when working with this chemical. Wear dust-proof chemical goggles and face shield unless full facepiece respiratory protection is worn. Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Mononitrotoluidines; Nitrotoluidines (mono)/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. /Mononitrotoluidines; Nitrotoluidines (mono)/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Mononitrotoluidines; Nitrotoluidines (mono)/|/GUIDE 153: SUBSTANCES - TOXIC AND/OR CORROSIVE (COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Mononitrotoluidines; Nitrotoluidines (mono)/|For more DOT Emergency Guidelines (Complete) data for 5-NITRO-O-TOLUIDINE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Upon dermal contact ... may irritate the skin ... .

The major hazards encountered in the use and handling of 5-nitro-o-toluidine stem from its toxicologic properties. Dermal or inhalation exposure to this yellow, crystalline substance may occur from its production, handling, or use as a chemical intermediate for dyes and pigments. The EPA has designated 5-nitro-o-toluidine as a Group C carcinogen, ie, it is considered to be possibly carcinogenic to humans. If contact with this substance should occur, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes, and wash exposed skin thoroughly with soap and water. This substance is a candidate for rotary kiln and fluidized bed forms of incineration.

U181; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

U181; As stipulated in 40 CFR 261.33, when 5-nitro-o-toluidine, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

5-Nitro-o-toluidinehas been detected at levels ranging from 0.0020 to 0.10 mg/L in waste water effluent from a plant manufacturing 2,4,6-trinitrotoluene(1).

nontoxic

LD50 Rat oral 574 mg/kg

5-Nitro-o-toluidine ... was selected ... in an attempt to elucidate those chemicals which may be responsible for the increased incidence of bladder cancer observed among workers in the dye manufacturing industry. ... 5-Nitro-o-toluidine was administered in the feed ... to groups of 50 male and 50 female animals of /Fischer 344 rats and B6C3F1 mice/. The time-weighted average high and low dietary concentrations of 5-nitro-o-toluidine were, respectively, 0.01 and 0.005 percent for rats, and 0.23 and 0.12 percent for mice. After a 78-week period of compound administration, observation of the rats continued for an additional 30 to 31 weeks and observation of the mice continued for up to an additional 20 weeks. ... There were no significant positive associations between the concentration of 5-nitro-o-toluidine administered and mortality in rats or mice of either sex, and adequate numbers of animals in all groups survived sufficiently long to be at risk from late-developing tumors. No unusual tumors were observed in rats of either sex and no convincing statistical evidence was provided for a significant positive association between compound administration and the incidence of any neoplasm in rats. Among mice there was a statistically significant positive association between administration of the chemical and the incidences of hepatocellular carcinomas in both males and females. The combined incidence of hemangiomas and hemangiosarcomas in male mice and the incidence of hemangiosarcomas in female mice were not statistically significant in relation to their respective control groups. However, they were considered to be associated with compound administration since they rarely occur in untreated B6C3F1 mice. Under the conditions of this bioassay 5-nitro-o-toluidine was carcinogenic in B6C3F1 mice, causing hepatocellular carcinomas in both sexes, an increase in the combined incidence of hemangiomas and hemangiosarcomas in male mice, and an increased incidence of hemangiosarcomas in female mice. The compound was not carcinogenic in Fischer 344 rats.

5-Nitro-o-toluidine's production and use in the synthesis of dye pigments(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 690 and 810 reported in sewage sludge(2), indicates that 5-nitro-o-toluidine is expected to have low mobility in soil(SRC). Volatilization of 5-nitro-o-toluidine from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 8.3X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 5-Nitro-o-toluidine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.8X10-4 mm Hg(SRC), determined from a fragment constant method(4). 5-Nitro-o-toluidine was reported to degrade 100% after 104 days in studies using activated sludge from a wastewater treatment plant with no previous exposure to nitroaromatic compounds, as well as in studies using inoculum from a plant that routinely treats dinitrotoluene-contaminated wastewater(5). Degradation products identified were 2,4-diaminotoluene, 4-nitrotoluene, and 6-nitroindazole(5).|AQUATIC FATE: Based on a classification scheme(1), Koc values of 690 and 810 reported in sewage sludge(2), indicates that 5-nitro-o-toluidine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 8.3X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4) According to a classification scheme(5), an estimated BCF of 5.5(SRC), from its log Kow of 1.87(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). 5-Nitro-o-toluidine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). 5-Nitro-o-toluidine was reported to degrade 100% after 104 days in studies using activated sludge from a wastewater treatment plant with no previous exposure to nitroaromatic compounds, as well as in studies using inoculum from a plant that routinely treats dinitrotoluene-contaminated wastewater(8). Degradation products identified were 2,4-diaminotoluene, 4-nitrotoluene, and 6-nitroindazole(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 5-nitro-o-toluidine, which has an estimated vapor pressure of 9.8X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 5-nitro-o-toluidine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.4 days(SRC), calculated from its rate constant of 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 2-Methyl-5-nitrobenzenamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 5-nitro-o-toluidine with photochemically-produced hydroxyl radicals has been estimated as 1.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 1.4 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 5-Nitro-o-toluidine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 5-Nitro-o-toluidine does not contain chromophores that absorb at wavelengths >290 nm(3) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 5.5 was calculated in fish for 5-nitro-o-toluidine(SRC), using a log Kow of 1.87(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Koc values of 690 and 810 were reported for 5-nitro-o-toluidine in sewage sludge(1). According to a classification scheme(2), these Koc values suggest that 5-nitro-o-toluidine is expected to have low mobility in soil.

The Henry's Law constant for 5-nitro-o-toluidine is estimated as 8.3X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 5-nitro-o-toluidine is expected to be essentially nonvolatile from water surfaces(2). 5-Nitro-o-toluidine's Henry's Law constant indicates that volatilization from moist soil surfaces will not occur(SRC). 5-Nitro-o-toluidine is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.8X10-4 mm Hg(SRC), determined from a fragment constant method(3).

SURFACE WATER: 5-Nitro-o-toluidine concentrations of 0.4, 0.1 and 0.1 ug/L were reported in two brooks and the River Losse near Hirschagen/Waldhof (Germany)(1). 5-Nitro-o-toluidine concentrations were <0.01 ug/L in two ponds and the River Oder (Germany)(1).

5-Nitro-o-toluidine was detected not quantified as a volatile flavor component of Idaho Russet Burbank baked potatoes(1).

Occupational exposure to 5-nitro-o-toluidine may occur through inhalation and dermal contact with this compound at workplaces where 5-nitro-o-toluidine is produced or used. (SRC)

5-Nitro-ortho-toluidine was identified as a product of the microbial transformation by Mucrosporium sp. of 2,4-dinitrotoluene, a compound common in water discharges and effluents from ammunition plants, ammunition loading facilities and sites for the destruction of stockpiled weapons ... . 5-Nitro-ortho-toluidine was identified as an intermediate in the anaerobic biotransformation of 2,4-dinitrotoluene added to a sample of municipal activated sludge ... . 5-Nitro-ortho-toluidine is formed enzymatically from 2,4-dinitrotoluene by liver and lung microsomal fractions from mice ... by liver microsomal and cytosolic fractions from rats ... and by intestinal microorganisms from rats and mice ... . 5-Nitro-ortho-toluidine and its N-acetyl derivative were identified as minor metabolites of 2,4-(14)C-dinitrotoluene when this compound was administered orally to male and female Fischer 344 rats at doses of 35, 63 or 100 mg/kg bw ... . Human intestinal microflora catalyse the reductive metabolism of 2,4-dinitrotoluene to 5-nitro-ortho-toluidine and 4-amino-2-nitrotoluene via nitroso intermediates ... .

5-Nitro-ortho-toluidine is available commercially with a purity of 99% ... .

SYMPTOMS: Symptoms of exposure to this chemical include methemoglobinemia and respiratory distress. ACUTE/CHRONIC HAZARDS: This compound is an irritant and an experimental carcinogen. It may be absorbed through the skin. When heated to decomposition this compound emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Aromatic hydrocarbons and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aromatic hydrocarbons and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Consider drug therapy for pulmonary edema ... . Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... .Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aromatic hydrocarbons and related compounds/|Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Nitrates, nitrites, and related compounds/|For more Antidote and Emergency Treatment (Complete) data for 5-NITRO-O-TOLUIDINE (6 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Methemoglobinemia is the major toxic effect observed following excessive absorption of 5-nitro-o-toluidine.. Symptoms of exposure include bluish lips and/or fingernails, headache, nausea, and fatigue|/SIGNS AND SYMPTOMS/ Methemoglobinemia ... is also the major toxic effect observed in workers following excessive exposure. In addition, upon dermal contact the compounds may irritate the skin and cause dermatitis.|/CASE REPORTS/ Of 15 workers in the same factory who handled 5-nitro-o-toluidine, three were hospitalized with symptoms of acute liver dysfunction. Suspecting a link between liver dysfunction and working conditions, ... workplace factors /were correlated/ with clinical findings in all 15 workers. ... Blood biochemistry tests indicated liver damage in seven of 15 study subjects. Workers who handled 5-nitro-o-toluidine and nitrosyl sulfuric acid often loosened their respiratory protective equipment shortly after 5-nitro-o-toluidine powder had been dispersed into the air of the room. No potential hepatotoxins were present except for 5-nitro-o-toluidine. Six of the affected workers had handled 5-nitro-o-toluidine 12 to 20 times; the seventh worker had handled the powder three times; and the other eight workers without liver dysfunction had handled the material once or twice. No other significant differences in background were evident between the affected and unaffected workers, such as age, sex, or protective measures. Histological findings during recovery from liver damage were similar to those of acute viral hepatitis. None of the 15 subjects has demonstrated liver damage since the factory was closed. ...

2-methyl-5-nitroaniline

ESSENTIALLY 100% AS CHEM INT FOR PIGMENTS & DYES.

Trade Names: Amarthol Fast Scarlet G Base; Amarthol Fast Scarlet G Salt; Azoene Fast Scarlet GC Base; Azoene Fast Scarlet GC Salt; Azofix Scarlet G Salt; Azogene Fast Scarlet G; Dainichi Fast Scarlet G Base; Daito Scarlet Base G; Devol Scarlet B; Devol Scarlet G Salt; Diabase Scarlet G; Diazo Fast Scarlet G; Fast Red SG Base; Fast Scarlet G; Fast Scarlet G Base; Fast Scarlet GC Base; Fast Scarlet G Salt; Fast Scarlet J Base; Fast Scarlet J Salt; Fast Scarlet M 4NT Base; Fast Scarlet T Base; Hiltonil Fast Scarlet G Base; Hiltonil Fast Scarlet GC Base; Hiltonil Fast Scarlet G Salt; Kayaku Scarlet G Base; Lake Scarlet G Base; Lithosol Orange R Base; Mitsui Scarlet G Base; Naphthanil Scarlet G Base; Naphtoelan Fast Scarlet G Base; Naphtoelan Fast Scarlet G Salt; Scarlet Base Ciba II; Scarlet Base Irga II; Scarlet Base NSP; Scarlet G Base; Sugai Fast Scarlet G Base; Symulon Scarlet G Base.

Synthetic dye and pigment manufacturing|Benzenamine, 2-methyl-5-nitro-: ACTIVE

Method: EPA-EAD 1625; Procedure: gas chromatography/mass spectrometry; Analyte: 5-nitro-o-toluidinie; Matrix: water; Detection Limit: not provided.|Method: EPA-OSW 8091; Procedure: gas chromatography with electron capture detector; Analyte: 5-nitro-o-toluidine; Matrix: water, soil, and waste matrices; Detection Limit: not provided.|Method: EPA-OSW 8270D; Procedure: gas chromatography/mass spectrometry; Analyte: 5-nitro-o-toluidine; Matrix: solid waste matrices, soils, air sampling media and water samples; Detection Limit: not provided.