 Home > Encyclopedia > Isoliquiritigenin

Isoliquiritigenin

Isoliquiritigenin structure

CAS No:
961-29-5
Formula:
C15H12O4
Chemical Name:
Isoliquiritigenin
Synonyms:
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-,(2E)-;Chalcone,2′,4,4′-trihydroxy-;2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-,(E)-;(2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;Isoliquiritigenin;2′,4,4′-Trihydroxychalcone;GU 17;Isoliquiritigen;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;78918-29-3
Categories:
Cosmetic Ingredient > Emollient

Description

Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM.

Solid

Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It derives from a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).|Isoliquiritigenin is a precursor to several flavonones in many plants.

Isoliquiritigenin Basic Attributes

Molecular Weight：

256.25

Exact Mass：

256.25

EC Number：

237-316-5

UNII：

B9CTI9GB8F

DSSTox ID：

DTXSID2022466

HScode：

2914501900

Characteristics

PSA：

77.8

XLogP3：

3.2

Appearance：

yellow to orange powder

Density：

1.4±0.1 g/cm3

Melting Point：

200 °C

Boiling Point：

504ºC at 760 mmHg

Flash Point：

272.7±24.4 °C

Refractive Index：

1.715

Water Solubility：

H2O: <0.1 mg/mL

Storage Conditions：

2-8°C

Collision Cross Section：

165.05 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]|187.37 Å² [M+Na]+ [CCS Type: DT, Method: stepped-field]|164.24 Å² [M-H]- [CCS Type: DT, Method: stepped-field]|158.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|163.7 Å² [M-H]-

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-37

RTECS Number：

FL7080000

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2',4',4-trihydroxychalcone

Isoliquiritigenin Use and Manufacturing

Uses

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reduc

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Chalcones and dihydrochalcones [PK1212]

Computed Properties

Molecular Weight:256.25
XLogP3:3.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:256.07355886
Monoisotopic Mass:256.07355886
Topological Polar Surface Area:77.8
Heavy Atom Count:19
Complexity:331
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Isoliquiritigenin

LEADER BIOCHEMICAL GROUP Contact Supplier

CN
8 YRS

Business licensed Certified factory

Manufactory Supplier of Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients,Natural Plant Ingredients,APIS Intermidiates,Daily Chemicals,Agricultural Chemicals,Surfactant Chemicals,Ultraviolet Absorbents,Antioxidant Ingredients,Scientific Research Chemical,Flavors and Fragrances Chemicals

China Most Professional Factory Supply High Qulity Isoliquiritigenin CAS 961-29-5

CAS No.: 961-29-5

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

Herbal extract manufacture PNQ supply Isoliquiritigenin

Unit Price: $100-110 /UNIT FOB

CAS No.: 961-29-5

Grade: Chemical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Isoliquiritigenin 99% white powder kanbei

CAS No.: 961-29-5

Grade: Industrial Grade

Content: 99%

Inquiry

Learn More Other Chemicals

Octamethylcyclotetrasiloxane

556-67-2
Sodium polyacrylate

9003-04-7
Elastins, cartilage, hydrolyzates

100085-10-7
Peptones Formula

73049-73-7
Glyceryl triacetoricinoleate Formula

101-34-8
1,3-Propanediol dicaprylate Formula

56519-71-2
Isopropyl laurate Structure

10233-13-3
(+)-Bakuchiol Structure

10309-37-2
What is Bis(2-ethylhexyl) adipate

103-23-1
What is Behenyl benzoate

103403-38-9

Hot Searches: lithium carbonate formula; celite; formula sulphur dioxide; bromhexine; chlorpheniraminmaleat; alumina molar mass

Guide of Isoliquiritigenin

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Learn More Other Chemicals

Isoliquiritigenin

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.