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Dicoumarol

Dicoumarol structure

CAS No:
66-76-2
Formula:
C19H12O6
Chemical Name:
Dicoumarol
Synonyms:
2H-1-Benzopyran-2-one,3,3′-methylenebis[4-hydroxy-;Coumarin,3,3′-methylenebis[4-hydroxy-;3,3′-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one];Acadyl;Bishydroxycoumarin;Bis(4-hydroxycoumarin-3-yl)methane;Dicoumarin;Dicoumarol;Dicumarine;Di-4-hydroxy-3,3′-methylenedicoumarin;3,3′-Methylenebis[4-hydroxy-1,2-benzopyrone];3,3′-Methylenebis[4-hydroxycoumarin];Dicumarol;Bis-3,3′-(4-hydroxycoumarinyl)methane;Cumid;Dicuman;Dicumol;Melitoxin;Acavyl;Antitrombosin;Kumoran;Baracoumin;Cuma;Temparin;Trombosan;Dicoumal;NC 034;NSC 41834;Dufalone;NSC 17860;NSC 221570;3,3′-Methylenebis(4-hydroxy-2H-chromen-2-one);PB 2-9;3,3′-Methylene-bis-(4-hydroxy-2H-benzopyran-2-one)
Categories:
Active Pharmaceutical Ingredients > Blood System Drugs

Description

Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.

Dicoumarol Basic Attributes

Molecular Weight：

336.29

Exact Mass：

336.30

EC Number：

200-632-9

HScode：

29322985

Characteristics

PSA：

93.1

XLogP3：

3.1

Appearance：

White Fine Crystalline Powder

Density：

1.6±0.1 g/cm3

Melting Point：

287-293 °C

Boiling Point：

620.7±55.0 °C at 760 mmHg

Flash Point：

231.9±25.0 °C

Refractive Index：

1.731

Water Solubility：

soluble in aqueous alkaline solutions, organic bases, 0.1 N NaOH (15 mg/ml), Pyridine (50 mg/ml), chloroform (slightly soluble ), and benzene (slightly soluble ). Insoluble in water, and alcohols.

Storage Conditions：

+2C to +8C

Toxicity：

Oral-Rat LD50: 250 mg/kg; Oral-Mouse LD50: 233 mg/kg

Flammability characteristics：

Heat breaks down and stimulates smoke; medicines have effects on the reproductive system: stillbirths, teratomas, poor babies; excessive drug bleeding

Odor：

Slight, pleasant odor

Taste：

Slightly bitter taste

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

22-48/25-51/53

safety instructions：

37-45-61

RTECS Number：

GN7875000

Marks：

T,N

Storage features：

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Precautionary statement(s)：

P260-P301 + P312 + P330

Hazard Statements：

H302-H372-H411

Toxicity

Toxicity class：

highly toxic

Dicoumarol Use and Manufacturing

anticoagulant

Drug Function and Efficacy

This product is a synthetic anticoagulant. Its anticoagulant effect is different from that of heparin. It mainly competes with vitamin K reversibly, inhibiting the synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X in liver cells, reducing the prothrombin content, and preventing the formation of blood clots. Since this product has no direct effect on the synthesized coagulation factors, it takes effect slowly, and generally reaches its peak 3 to 5 days after oral administration; and since the effect of this product disappears only after the coagulation factors are restored to a certain level after discontinuation of use, the effect can still be maintained for 2 to 10 days when the drug is discontinued when hypoprothrombinemia occurs. This product can also reduce thrombin-induced platelet aggregation reaction, but has no in vitro anticoagulant effect.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dicoumarol Tablets
Ingredients	The main component of this product is dicoumarin. Chemical name: 3,3'-methylenebis[4-hydroxy-2H-1-benzopyran-2-one] Molecular formula: C19H12O6 Molecular weight: 336.31
Indication	When this product is used in combination with phenylbutazone, salicylates, hydroxyphenylbutazone, indomethacin, para-aminosalicylic acid, mefenamic acid, chlorpheniramine, chloral hydrate, quinine, quinidine, anabolic hormones, chloramphenicol, tetracyclines, sulfonamides, tolbutamide, clofibrate, and cholestyramine, the free form of this product in the blood increases due to competition for plasma protein binding, which enhances the anticoagulant effect of this product and increases the bleeding tendency. When this product is used in combination with doxorubicin, griseofulvin, phenobarbital, phenytoin sodium, rifampicin, vitamin K, oral contraceptives, adrenocortical hormones, and estrogen, the activity of liver drug enzymes is induced, which increases the degradation of this product, thus reducing the efficacy of this product and the dosage of this product should be adjusted.
Specifications	50mg
Manufacturer	Shanghai Sine Pharmaceutical Laboratories Co., Ltd.

Registered Holders

ABBOTT LABORATORIES PHARMACEUTICAL PRODUCTS DIV

United States
Inactive

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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DICUMAROL

CAS No.: 66-76-2

Content: 99.00%

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