2-Naphthalenecarboxaldehyde
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2-Naphthalenecarboxaldehyde
structure -
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CAS No:
66-99-9
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Formula:
C11H8O
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Chemical Name:
2-Naphthalenecarboxaldehyde
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Synonyms:
2-Naphthalenecarboxaldehyde;2-Naphthaldehyde;β-Naphthaldehyde;β-Naphthylcarboxaldehyde;2-Formylnaphthalene;β-Formylnaphthalene;2-Naphthylcarboxaldehyde;2-Naphthylaldehyde;β-Naphthoaldehyde;NCR 1 (aldehyde);NCR 1;Naphthalene-2-carbaldehyde;2-Naphthalenealdehyde;NSC 8557;2-Napthaldehyde
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CAS No:
Description
Pink crystalline
2-Naphthalenecarboxaldehyde is used to prepare chalcone analogs with increased antileishmanial activities. It is also used to synthesize (aryl)(oxo)spiro[cyclopropane-1,3'-indole] derivatives with their activities as HIV-1 non-nucleoside reverse transcriptase inhibitors.
2-naphthaldehyde is a naphthaldehyde that is naphthalene substituted by a formyl group at position 2. It has a role as a mouse metabolite.
2-Naphthalenecarboxaldehyde Basic Attributes
156.18
156.18
507750
200-640-2
GZX30H50DE
8557
DTXSID6075352
1.0755
29122900
Characteristics
17.1
3
Off-white to yellow or light beige Powder or Chunks
1.2±0.1 g/cm3
62 °C
95-96 °C @ Press: 3 Torr
160°C/19mm
1.676
soluble in hot water.
-20°C
Safety Information
I; II; III
UN 3335
3
36/37/38-22
22-24/25-36-26
QJ0190010
Xn,Xi
Stable under normal temperatures and pressures.
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 7 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Naphthalenecarboxaldehyde Use and Manufacturing
Pass dry hydrogen chloride into the mixture of anhydrous tin dichloride and anhydrous ether, add 2-naphthalenenitrile ether solution when it is saturated, and then pass hydrogen chloride to saturation to generate yellow aldimine and tin tetrachloride complex Compound. The complex is steam distilled, and the white solid product is filtered out from the distillate, which is the crude 2-naphthaldehyde. After distillation under reduced pressure, the pure product is obtained with a yield of about 70%.
For organic synthesis
Analysis Methods
| Name | Column Shape | Active Phase(℃) | Retention index | Temperature Control | Method | Comments | Reference |
|---|---|---|---|---|---|---|---|
| Van Den Dool and Kratz RI, polar column, temperature ramp | Capillary | Supelcowax-10 | 2407. | temperature ramp | 60. m/0.25 mm/0.25 μm, He, 35. C @ 5. min, 2. K/min, 195. C @ 90. min | Chung, H.Y.Yung, I.K.S.Kim, J.-S.Comparison of volatile components in dried scallops (Chlamys farreri and Patinopecten yessoensis) prepared by boiling and steaming methodsJ. Agric. Food Chem.2001, 49, 1, 192-202. | |
| Van Den Dool and Kratz RI, polar column, temperature ramp | Capillary | Methyl Silicone | 1468. | custom temperature program | 25. m/0.25 mm/0.25 μm, He; Program: 50 0C (2 min) 20 0C/min -> 160 0C 5 0C/min -> 210 0C 10 0C/min -> 300 0C | Oda, J.Yasuhara, A.Matsunaga, K.Saito, Y.Identification of polycyclic aromatic hydrocarbons of the particulate accumulated in the tunnel duct of freeway and generation of their oxygenated derivativesJpn. J. Toxicol. Environ. Health1998, 44, 5, 334-351. | |
| Van Den Dool and Kratz RI, polar column, temperature ramp | Capillary | SPB-5 | 258.2 | temperature ramp | 40. C @ 2. min, 4. K/min; Column length: 30. m; Column diameter: 0.25 mm; Tend: 300. C | Knobloch, T.Engewald, W.Identification of some polar polycyclic compounds in emissions from brown-coal-fired residential stovesJ. Hi. Res. Chromatogr.1993, 16, 4, 239-242. | |
| Van Den Dool and Kratz RI, polar column, temperature ramp | Capillary | DB-5 | 259.1 | custom temperature program | Column length: 60. m; Program: not specified | Fuentes, M.J.Font, R.Gomez-Rico, M.F.Martin-Gullon, I.Pyrolysis and combustion of waste lubricant oil from diesel cars: Decomposition and pollutantsJ. Anal. Appl. Pyrolysis2007, 79, 1-2, 215-226. | |
| Van Den Dool and Kratz RI, polar column, temperature ramp | Capillary | DB-5MS | 257.9 | custom temperature program | Column length: 60. m; Column diameter: 0.25 mm; Program: not specified | Aracil, I.Font, R.Conesa, J.A.Semivolatile and volatile compounds from the pyrolysis and combustion of polyvinyl chlorideJ. Anal. Appl. Pyrolysis2005, 74, 1-2, 465-478. |
Computed Properties
Molecular Weight:156.18
XLogP3:3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:156.057514874
Monoisotopic Mass:156.057514874
Topological Polar Surface Area:17.1
Heavy Atom Count:12
Complexity:164
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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