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Bifemelane

Bifemelane structure

CAS No:
90293-01-9
Formula:
C18H23NO
Chemical Name:
Bifemelane
Synonyms:
1-Butanamine,N-methyl-4-[2-(phenylmethyl)phenoxy]-;N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine;Bifemelane;4-(o-Benzylphenoxy)-N-methylbutylamine;[4-(2-Benzylphenoxy)butyl](methyl)amine
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

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Description

N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine is a diarylmethane.

Bifemelane Basic Attributes

Molecular Weight：

269.38

Exact Mass：

269.38

UNII：

Z4501GN13G

DSSTox ID：

DTXSID1045663

ATC Code：

N - Nervous system

HScode：

2922299090

Characteristics

PSA：

21.3

XLogP3：

4.19

Density：

1.0±0.1 g/cm3

Boiling Point：

395℃

Flash Point：

169℃

Refractive Index：

1.543

Storage Conditions：

Desiccate at RT

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

MeSH Entry Terms：

2-(4-methylaminobutoxy)diphenylmethane

Bifemelane Use and Manufacturing

Methods of Manufacturing

36.8g of o-benzylphenol, 13.2g of potassium hydroxide, 200ml of toluene and 90.0g of 1, 4-dibromobutane were refluxed for 12h to obtain 40.0g of compound (II) with a yield of 62%. 5g of compound (II) and 20ml of 40% methylamine aqueous solution were dissolved in ethanol and reacted at room temperature for 8 hours. After treatment with hydrochloric acid, dibenzapene hydrochloride was obtained with a yield of 96%.

Uses

Brain metabolism activator. It can activate brain energy metabolism, dilate cerebral blood vessels, increase cerebral blood flow and improve cerebral nerve conduction. It is used to improve the consciousness and emotional disturbances associated with the sequelae of cerebral infarction and sequelae of cerebral hemorrhage.

Computed Properties

Molecular Weight:269.4
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:269.177964357
Monoisotopic Mass:269.177964357
Topological Polar Surface Area:21.3
Heavy Atom Count:20
Complexity:238
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes