Tedisamil
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Tedisamil
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CAS No:
90961-53-8
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Formula:
C19H32N2
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Chemical Name:
Tedisamil
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Synonyms:
Spiro[cyclopentane-1,9′-[3,7]diazabicyclo[3.3.1]nonane],3′,7′-bis(cyclopropylmethyl)-;3′,7′-Bis(cyclopropylmethyl)spiro[cyclopentane-1,9′-[3,7]diazabicyclo[3.3.1]nonane];Tedisamil
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CAS No:
Description
Tedisamil is a member of the class of diazabicyclononanes that is (1s,5s)-3,7-diazaspiro[bicyclo[3.3.1]nonane-9,1'-cyclopentane] in which the hydrogens at positions 3 and 7 are replaced by cyclopropylmethyl groups. It is a potassium channel blocker and an antiarrhythmic agent currently currently in development for the treatment of atrial fibrillation. It has a role as an anti-arrhythmia drug and a potassium channel blocker. It is an azaspiro compound, a member of cyclopropanes, a member of cyclopentanes and a diazabicyclononane.|Tedisamil (planned trade name Pulzium) is an investigational drug for atrial fibrillation and atrial flutter. It is currently being developed by Solvay and is currently under regulatory review by the United States Food and Drug Administration.
Drug Information
Investigated for use/treatment in arrhythmia, atrial fibrillation, and angina.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)
It is hypothesized tedisamil prevents Ca2+ overload by the cAMP dependent SR Ca2+ uptake [PMID: 10707827].
3,7-di-(cyclopropylmethyl)-9,9-tetramethylene-3,7-diazabicyclo(3.3.1)nonane