O-(2-MethoxyEthoxy)BenzeneSulfonamide

The preparation method is based on 2-chloro-5-nitrobenzenesulfonic acid as a raw material, firstly with sodium hydroxide to generate the corresponding sulfonic acid sodium salt, and further react with 2-methoxyethanol to etherify to obtain 2-(2-methyl Sodium oxyethoxy)-5-nitrobenzene sulfonate reacts with phosphorus oxychloride to generate the corresponding sulfonyl chloride. The sulfonyl chloride reacts with ammonia to obtain 2-(2-methoxyethoxy)-5- Nitrobenzene sulfonamide, further reducing the nitro group with sodium sulfide to amino compound, then reacting with sodium nitrite and hydrochloric acid in ethanol, diazotizing, and then denitrifying to obtain 2-(2-methoxyethoxy) Benzenesulfonamide. Another method is to use 2-chlorobenzenesulfonamide as the raw material, firstly react with the sulfonamide with bromide to protect the amino group, then react with ethylene glycol monomethyl ether, and finally hydrolyze the finished product.

O-(2-methoxyethoxy)benzenesulfonamide is an intermediate of sulfonylurea herbicide ethersulfuron.