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Isobutyramide

Isobutyramide structure

CAS No:
563-83-7
Formula:
C4H9NO
Chemical Name:
Isobutyramide
Synonyms:
Propanamide,2-methyl-;Isobutyramide;2-Methylpropanamide;Isobutyrimidic acid;Isopropylformamide;Isobutanamide;2-Methylpropionamide;VX 366;NSC 8423
Categories:
Organic Chemistry > Amides

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Description

white needle-like crystalline powder

Isobutyramide Basic Attributes

Molecular Weight：

87.12

Exact Mass：

87.12

EC Number：

209-265-9

UNII：

82UOE7B38Z

NSC Number：

8423

DSSTox ID：

DTXSID1060340

HScode：

2924199090

Characteristics

PSA：

43.1

XLogP3：

0.2

Appearance：

white needle-like crystalline powder

Density：

0.9±0.1 g/cm3

Melting Point：

128 °C

Boiling Point：

218 °C

Flash Point：

216-220°C

Refractive Index：

1.418

Water Solubility：

soluble in water.

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

24/25

RTECS Number：

TX1475000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (95.12%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

isobutyramide

Isobutyramide Use and Manufacturing

Methods of Manufacturing

After isobutyric acid is chlorinated to obtain isobutyryl chloride, it is obtained by amidation. Add isobutyryl chloride dropwise to concentrated ammonia water under vigorous stirring, and control the feeding speed so that the temperature does not exceed 15°C. After the addition was completed, the mixture was stirred for 1 h, and the mixture was evaporated to dryness under reduced pressure. The residue was isobutyramide and ammonium chloride. Ethyl acetate was added to the residue, boiled for 10 minutes, filtered, and vacuum dried to obtain the finished product.

Uses

Used in organic synthesis, preparation of isobutyronitrile, etc.

Manufacturing Info：

Propanamide, 2-methyl-: ACTIVE

Computed Properties

Molecular Weight:87.12
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:87.068413911
Monoisotopic Mass:87.068413911
Topological Polar Surface Area:43.1
Heavy Atom Count:6
Complexity:58.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Isobutylene

tert-Butylamine

Isobutyraldehyde

Isobutyric acid

Oxalyl chloride

Downstream Products

CeftazidiMe

Ammonia

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Isobutyramide.

CAS No.: 563-83-7

Grade: Chemical Grade

Content: 99%

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
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CAS No.: 563-83-7

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CN
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Isobutyramide Industrial Grade

CAS No.: 563-83-7

Grade: Industrial Grade

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