4-Methyl-1-phenyl-2-pentanone

4-Methyl-1-phenyl-2-pentanone is an endogenous metabolite.

colourless oily liquid with a sweet, woody, spicy, burnt sugar odour

4-Methyl-1-phenyl-2-pentanone is a member of benzenes.

General procedure: A 25mL sealed tube was charged with aromatic ketones 1(0.2 mmol, 2.0 equiv), diphenylacetylene 2a (0.1 mmol, 1.0 equiv), [RuCl2(p-cymene)]2 (0.015 mmol, 15 molpercent), KOAc (0.2 mmol, 2.0equiv), Na2CO3 (0.2 mmol, 2.0 equiv) and PhMe (0.5 mL). The vialwas evacuated and filled with N2 atmosphere, and stirred at 100 Cfor 24 h. After being cooled to room temperature, the mixture wasevaporated under reduced pressure. The residue was purified byflash column chromatography on silica gel, eluting with petroleumether to afford the desired products 4.Diphenylacetylene (18 mg, 0.1 mmol) was added to a 25 mL sealed tube with magnetite, corresponding to the aromatic ketone(0.2 mmol), catalyst [RuCl 2 (p-cymene)] 2 (9 mg, 15percent mol), 0.5 mL toluene, followed by the addition of dry sodium carbonate(21 mg, 0.2 mmol) and potassium acetate (19 mg, 0.2 mmol), purged nitrogen three times, reacted at 100°C for 24 hours, and then passed through a column Chromatographic separation (eluent: petroleum ether) gave the target compound. Characterized as follows.3-Isobutyl-1, 2-diphenylnaphthalene: Yield: 35percent

Flavoring.

Molecular Weight:176.25
XLogP3:2.7
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:176.120115130
Monoisotopic Mass:176.120115130
Topological Polar Surface Area:17.1
Heavy Atom Count:13
Complexity:155
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes