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Bacitracin

Bacitracin structure

CAS No:
1405-87-4
Chemical Name:
Bacitracin
Synonyms:
Bacitracin;Ayfivin;Baciguent;Baci-Jel;Bacitek Ointment;Parentracin;Penitracin;Topitracin;Zutracin;Bacilliquin;Bacillichin;Tropitracin;Altracin;Fortracin;1405-75-0;12640-37-8;60454-67-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

White to pale buff powder Bacitracin is a white to light tan powder which is odorless or having a slight odor and very bittertaste.A complexof cyclic peptide antibiotic of known chemicalstructure isolated from the Tracy-I strain of Bacillussubtilis. The organism from which Johnson et al. produced bacitracinin 1945 is a strain of B. subtilis. The organism hadbeen isolated from debrided tissue from a compound fracturein 7-year-old Margaret Tracy, hence the name “bacitracin.”Bacitracin is now pro

Bacitracin Basic Attributes

Molecular Weight：

1421.68538

Exact Mass：

1421.748901

EC Number：

215-786-2

HScode：

29419090

Characteristics

PSA：

556.17000

XLogP3：

3.72410

Appearance：

white to faintly beige Powder

Density：

1.0166 (rough estimate)

Melting Point：

221-225°C

Boiling Point：

1755.5°C at 760 mmHg

Flash Point：

1015.5±34.3 °C

Refractive Index：

1.6700 (estimate)

Water Solubility：

H2O: 50 mg/mL, clear to very slightly hazy, deep yellow

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

Peritoneal-rat LD50: 190 mg/kg; peritoneal-mouse LD50: 300 mg/kg

Flammability characteristics：

Combustible, burning produces irritating smoke

Safety Information

Transport codes：

UN 3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

wgk germany：

hazard class code：

20/21/22

safety instructions：

22-24/25-45-36

RTECS Number：

CP0175000

Marks：

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Toxicity

Toxicity class：

highly toxic

Bacitracin Use and Manufacturing

Methods of Manufacturing

The producing bacterium is Bacillus subtilis. The medium is defatted soybean flour (5%), sucrose (1.2%), ammonium sulfate (0.2%), calcium carbonate (0.2%), etc. The cultivation process of bacteria can be divided into two stages: bacterial development and antibiotic production. The optimal temperature for producing bacitracin is about 37℃, while the temperature during the bacterial development period needs to be slightly higher than 1-2℃, and the ventilation per minute is 90% of the fermentation broth. The bacitracin produced is adsorbed on the carboxylic acid type exchange resin under a pH value of 4-5.7, and then eluted with a weak base (ammonia).

Uses

Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.

Material

Zinc oxide (ZnO)

Calcium carbonate

Drug Function and Efficacy

It has a strong antibacterial effect on Gram-positive bacteria such as Staphylococcus and Streptococcus. It also has a certain effect on Neisseria gonorrhoeae, Neisseria meningitidis and some spirochetes and actinomycetes. All Gram-negative bacteria are resistant. Systemic medication can cause severe nephrotoxicity, so it is currently limited to local application.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound neomycin ointment
Ingredients	This product is a compound preparation, containing 2000 units of neomycin and 250 units of bacitracin per gram.
Indication	1 Avoid using with nephrotoxic or ototoxic drugs. 2 If you are using other drugs, you should consult your doctor or pharmacist before using this product. This product is usually poorly absorbed when applied topically and is therefore less likely to cause interactions with other drugs.
Specifications	Neomycin sulfate 20,000 units, bacitracin 2,500 units
Manufacturer	Mayinglong Pharmaceutical Group Co., Ltd.

Compound polymyxin B ointment (formerly known as compound polymyxin B ointment)
Ingredients	Polymyxin B sulfate, neomycin sulfate, bacitracin, and lidocaine hydrochloride are based on vaseline.
Indication	This product is rarely absorbed when applied topically to a small area of skin and is unlikely to cause interactions with other drugs.
Specifications	Compound
Manufacturer	Zhejiang Fonow Medicine Co., Ltd.

Bacitracin
Manufacturer	North China Pharmaceutical Huasheng Co., Ltd.

See More Related Drugs

Registered Holders

Joyang Laboratories

United States
Active
XELLIA PHARMACEUTICALS ApS

Denmark
Active
Xellia (Taizhou) Pharmaceuticals Co., Ltd.

China
Active

See More Registered Holders

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