Potassium bicarbonate

100.11500

99.95630

241-378-9

HM5Z15LEBN

DTXSID0021177

A12BA30|A - Alimentary tract and metabolism

2836400000

60.36000

-1.11230

DryPowder; OtherSolid

2.17

100 °C

333.6ºC at 760mmHg

NotºConsidered to be a fire hazard

Freely soluble in water. Insoluble in ethanol

Store at RT.

LD50 orally in Rabbit: > 2000 mg/kg

6.37None

6.37

NONH for all modes of transport

1

R22

S24/25; S45; S36/37/39; S26

C; T; F; Xi

Stable.

P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, P501

H319

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 29 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319 (99.36%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P261, P264, P271, P280, P304+P340, P305+P351+P338, P312, P337+P313, P403+P233, P405, and P501|Aggregated GHS information provided by 393 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Potassium bicarbonate does not contain any toxic chemicals and it is not listed as a carcinogenic or a potential carcinogen. Potassium bicarbonate is also considered safe in pregnancy as the current data do not suggest a teratogenic potential or any developmental toxicity.

Potassium bicarbonate is used as an antacid, electrolyte replenisher and potassium supplement. It can also be used as an excipient in drug formulations. An antacid is a medication used to neutralize gastric acid in a short timeframe after ingestion and the effect is soon overcome by meal-stimulated acid secretion.|Treatment of renal tubular acidosis|Sibnayal is indicated for the treatment of distal renal tubular acidosis (dRTA) in adults, adolescents and children aged one year and older.,

Potassium is the principal intracellular cation in most body tissues. The concentration of potassium ions is essential to conduct nerve impulses in specialized tissues like brain, heart and skeletal muscle, as well as to maintain normal renal function, acid-base balance, and cellular metabolic functions. The use of compounds containing bicarbonate is showed to produce the release of CO2. This effect has been one of the problems of the use of potassium bicarbonate as it can cause eructation.

Potassium bicarbonate intake is done mainly in the small intestine in which approximately 90% of the potassium will be absorbed by passive diffusion.|Approximately 90% of the exogenous potassium consumed is lost in the urine while the other 10% is excreted in feces and a very small amount can be found in the sweat. The excreted potassium is freely filtered by the glomerulus of the kidney.

Some reports have shown that after absorption, most body potassium exchanges rapidly with a half-life of less than 7 hours.

The antacid potential of potassium bicarbonate is attained by increasing the gastrointestinal pH by neutralizing hydrochloric acid. The increase in pH results in suppression of the action of pepsin which is the enzyme that exacerbates ulceration due to the presence of acid.

KHCO3

All other basic inorganic chemical manufacturing|Carbonic acid, potassium salt (1:1): ACTIVE

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives|Human Drugs -> EU pediatric investigation plans|Human drugs -> Sibnayal -> EMA Drug Category|Mineral supplements -> Human pharmacotherapeutic group|Food Additives -> ACIDITY_REGULATOR; LEAVENING_AGENT; RAISING_AGENT; -> JECFA Functional Classes|Cosmetics -> Buffering

Food Additives -> ACIDITY_REGULATOR; LEAVENING_AGENT; RAISING_AGENT;