Aminocarb

208.26

208.26

217-990-7

767M03K32Y

0097

2757

DTXSID7022172

WHITE CRYSTALLINE SOLID|TAN CRYSTALS

2924199090

41.6

1.73

WHITE CRYSTALS.

1.095

93-94 °C

307.3±42.0 °C at 760 mmHg

100 °C

1.547

Solubility in water, g/100ml at 20°C: 0.09 (very poor)

0-6°C

Vapour pressure, Pa at 20°C: 0.0023

Relative vapour density (air = 1): 7.2

Oral-rat LD50: 30 mg/kg; Oral-Mouse LDL0: 94 mg/kg

Thermal decomposition of toxic nitrogen oxide gas

Henry's Law constant is 5.64X10-10 atm cu m/mole (est).

II

6.1(a)

2757

24/25-50/53

28-36/37-45-60-61

FC0175000

T,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

ACTIVE INGREDIENT IS UNSTABLE IN STRONGLY ALKALINE MEDIA.

P273-P280-P301 + P310-P312-P501

H301 + H311-H410

Hydrolysis: Mix aminocarb with excess CaO /calcium oxide/ or NaOH /sodium hydroxide/ and sand or other adsorbent in a pit or trench at least 0.5 m deep in a clay soil. NaOH or Na2CO3 /sodium carbonate/ can also be added to the mixture to help speed the reactions when CaO is used as the main alkali. The amt of CaO or NaOH to use depends on the amt of pesticide to be disposed of and, to some extent, the concentration of active ingredient in the pesticide and the actual chemical nature of the active ingredient. A practical guideline, in the absence of specific directions, is to use an approx volume or weight of alkali from one-half of to the same as that of the pesticide. For dilute formulations, such as a 1% soln or dust, the amount of CaO of NaOH can be reduced by one-half. For very concentrated pesticides (over 80% active ingredient) the amount of CaO or NaOH can be doubled, but the concentrate should be mixed first with water (or soapy water) before reaction with the alkali. For safety, a preliminary test should be made in which very small amt of the pesticide and alkali are mixed and observed briefly to make sure it does not react too vigorously. Sizable quantities of pesticides can be disposed of in several smaller batches, rather than all at once, for added safety. Recommendable methods: Incineration & landfill. Peer-review: Large amt should be incinerated in a unit with effluent gas scrubbing. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. Risk of fire and explosion if formulations contain flammable/explosive solvents.

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P273, P280, P301+P310, P302+P352, P312, P321, P322, P330, P361, P363, P391, P405, and P501|H301 (91.11%): Toxic if swallowed [Danger Acute toxicity, oral]|Aggregated GHS information provided by 45 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Use powder, water spray, foam, carbon dioxide.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. Separated from food and feedstuffs.

A harmful concentration of airborne particles can be reached quickly on spraying.

Cholinesterase inhibition. The substance may cause effects on the nervous system. Exposure could cause death. The effects may be delayed. Medical observation is indicated.

The substance may have effects on the nervous system.

NO open flames.

AVOID ALL CONTACT! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!

Use local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear face shield or eye protection in combination with breathing protection.

SOURCE DOMINATED: The concn of aminocarb at a distance 2km-3km downwind following application of the insecticide at a rate of 70 g a.i./ha ranged 0 to 4.2 ug/cu m within less than 30 mins of application(1). Aminocarb concn decreased rapidly to less than 0.1 ug/cu m within an hour of spray application(1). Even at a height of 30 cm above the application area, the atmospheric concn was nearly undetectable 24 hrs after spraying(2).

most toxic

LD50 Rat oral 30-50 mg/kg|LD50 Rat ip 21 mg/kg|LD50 Rat percutaneous 275 mg/kg|LC50 Rat oral 50 mg/kg

Aminocarb is not known to occur naturally. (SRC)

Since aminocarb is commercially produced and used as an inseticide(1), it may be released to the environment during use and some release may occur during production(SRC).

TERRESTRIAL FATE: Based on degradation studies in water(1), both biodegradation and hydrolysis may be the major processes for the degradation of aminocarb from soil(SRC). Because of the inability of sunlight to penetrate beyond soil surface, photolysis will not be important beyond the top layers of soil(SRC). Based on low estimated values for vapor pressure (1.88X10-6 mm Hg) and Henry's Law constant (5.64X10-10 atm cu m/mole), volatilization of aminocarb from dry and wet soil should not be important(SRC). The estimated Koc value of 100-210 indicates that aminocarb should exhibit high to moderate leaching in soil(4,SRC). The persistence of aminocarb in soil will depend on the soil type, moisture content, pH and the temperature of soil(2). In a conifer forest soil (sandy loam) of pH 6.2 and temperatures of 10-22.3 °C, the persistence of aminocarb did not exceed 8 days(3).|AQUATIC FATE: Aminocarb will degrade by a combination of hydrolysis, photolysis and biodegradation in water(1). The half-life of aminocarb in a creek water from Moncton, New Brunswick, Canada with a natural pH of 6.52 was 11.5 days(1). The hydrolysis of aminocarb in water will be faster at higher pH(1). In 14 days, 90% aminocarb degraded in Little Miami River water from Ohio and it was totally degraded in less than 4 weeks(2). Under field application conditions, residues of aminocarb disappeared rapidly (3-25 hrs) from water, sediment and fish(3). The log BCF value of less than 5(4-6) indicates that bioconcentration of aminocarb in aquatic organisms will not be important(SRC).|ATMOSPHERIC FATE: Based on a vapor pressure of 1.88X10-6 mm Hg estimated from Henry's Law constant(1) and water solubility(2), aminocarb may be present partially in the vapor phase and partially in the particulate form in air(3,SRC). Based on an estimation method(4), vapor phase aminocarb may be removed from the atmosphere with a half-life of less than 1 hr. due to reaction with photochemically produced hydroxyl radicals(SRC). Partial removal of particulate aminocarb from the air may occur by dry deposition(SRC). Both vapor and particle phase aminocarb may be partly removed from the atmosphere by wet deposition(SRC).

EXPOSURE OF MATACIL TO UV LIGHT (2537 A) PRODUCED AT LEAST ELEVEN DEGRADATION PRODUCTS. OF THESE, 4 CMPD IDENTIFIED WERE IDENTICAL WITH THOSE FOUND ON BEAN PLANTS.|Water pollution factors: aquatic reactions: persistence in riverwater in a sealed glass jar in sunlight and artificial fluorescent light initial concn 10 ug/l: % of original cmpd found after 1 hr: 100%; 1 wk: 60%; 2 wk: 10%; 4 and 8 wk: 0%.|The hydrolysis half-lives of aminocarb in water at 25 °C and pH 6, 7 and 8 were 17.3 days, 14.2 days and 6.2 days, respectively(1). The hydrolysis proceeded with the formation of 4-(dimethylamino)-3-methylphenol which subsequently formed 6-(dimethylamino)-2-methyl-1,4-benzoquinone, 5-(dimethylamino)-2-methyl-1,4-benzoquinone, 6-(methylamino)-2-methyl-1,4-benzoquinone and 5-(methylamino)-2-methyl-1,4-benzoquinone(2,3). When an aqueous solution of aminocarb at pH 6.52 was exposed to outdoor sunlight at 15 °C, it degraded with a half-life of 11.6 days compared to a half-life of 14 days for the solution stored in the dark at 25 °C(1). Therefore, it appears that aminocarb undergoes photolysis in water(1). The main product of photolysis of aminocarb in hexane and ethanol was 4-(dimethylamino)-3-methylphenol(4). Aminocarb vapor in the atmosphere will also undergo photolysis, although the kinetics of atmospheric photolysis under natural sunlight conditions were not determined(5).|Based on an estimation method(1-2), the rate constant for the reaction of vapor phase aminocarb with hydroxyl radicals in air is 2.75X10-10 cu cm/molecule-sec(SRC). This corresponds to a half-life of less than 1 hr, based on a 12-hr average OH concentration of 1.5X10+6 radicals/cu cm in the atmosphere.

Fingerling rainbow trout (Salmo gairdneri) were used to determine the lethal toxicity of Matacil 1.8 F and Matacil 1.8 D ready-to-use formulations. The 96 hr median lethal concentrations were 21.3 mg/l for water-based Matacil 1.8 F; 29.1 mg/l for oil-based Matacil 1.8 F; and 0.36 mg/l for Matacil 1.8 D. Aminocarb and 4-methylamino-m-tolyl N-methylcarbamate were detected in fish tissue 96 hr after exposure. More than 50% of the total residue was the parent cmpd. The bioaccumulation ratio ranged from 1.70 to 3.32 at different concn of aminocarb. Both aminocarb and 4-methylamino-m-tolyl N-methylcarbamate were rapidly eliminated after the fish had been transferred to clean water.|The bioconcentration factor for aminocarb in muscle and bone of Brown Bullhead (Ictalurus nebulosus) was determined to be in the range 2.6-3.6(1-2). In whole body of mussels (Mytilus edulis), the steady state bioconcentration factor was 3.8- 4.9(3). The low bioconcentration of aminocarb in these aquatic organisms is due to rapid elimination of the parent compound from tissues(1-2).

100.00 L/kg|Based on regression equations(3) and the water solubility of 915 mg/l(1) and a log Kow value of 1.734(2), the estimated log Koc for aminocarb is in the range 2.01-2.32(SRC). According to a suggested classification scheme(4), this range of log Koc values indicates that aminocarb is moderately to highly mobile in soil(4). Conversely, it would be weakly to moderately sorbed to suspended soils and sediment in water(SRC).

Based on an estimated Henry's Law constant of 5.636X10-10 atm-cu m/mole(1), the volatilization half-life of aminocarb from a 1 m deep model river flowing at a current speed of 1 m/sec and a wind speed of 3 m/sec would be hundreds of years(2,SRC). Therefore, volatilization of aminocarb from water may not be important(SRC).

SURFACE WATER: The concn range of aminocarb in a still lake water (directly exposed) one hr. after spraying at a rate 52 g a.i./ha was less than 0.01 to 331 ug/l. The concn of aminocarb in an exposed stream one hr. following spraying was less than 0.01 to 18.4 ug/l(1). The median concn in both waters hardly exceeded 1 ug/l one hr. after spraying(1). The level will decrease rapidly in water with time(1). Metabolites of aminocarb have never been detected in natural water after aerial spraying(2).|Aminocarb applied to the surface of a stream dispersed throughout the water column within 100 m of the place of application. Concn in the water were first highest near the surface, later more or less evenly distributed, and lingered longest near and within the stream bottom. Both oil and water based formulations of Matacil 1.8F gave similar results. Aminocarb concn diminished logarithmically downstream. Concn of aminocarb in suspended particles, sediments, periphyton, higher plants, insects, and brook trout were not higher than ambient in water and dissipated quickly. Aminocarb phenol was found consistently in measurable concn in water treated with the aq formulation, but in much smaller concn in water treated with the oil formulation. It was also found only as very small amt in 3 sediment samples in the stretch treated with the aq formulation. A slight increase in drift of Chironomidae was probably caused by aminocarb. No effects on survival, drift, or species composition of phytoplankton were noted.

Applicators are the most likely group for exposure to aminocarb(SRC). Judging from the formulations used for field application, the most probable routes of exposure to aminocarb among this group would be inhalation and dermal contact(1,SRC).

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

THESE CMPD ARE RAPIDLY METABOLIZED & EXCRETED IN URINE. /CARBAMATES/|Readily absorbed through intact skin ... .|Uptake and clearance of aminocarb by Caecidolea racovitzai racovitzai were shown to be proportional to exposure temp, indicating that they may be active processes. Control of clearance may be a function of the rate of metab of aminocarb in vivo. Both uptake and clearance were shown to occur in two compartments.|Penetration of the blood-brain barrier by the carbamates is insignificant; for this reason, fewer CNS symptoms occur. /Carbamate pesticides/|For more Absorption, Distribution and Excretion (Complete) data for AMINOCARB (6 total), please visit the HSDB record page.

YIELDS 4-DIMETHYLAMINO-3-METHYLPHENYL N-HYDROXYMETHYLCARBAMATE & 3-METHYL-4-METHYLAMINOPHENYL N-METHYLCARBAMATE IN MAN & IN RAT.|AFTER TREATMENT OF GROWING BEAN LEAVES WITH LABELED MATACIL, @ LEAST 8 COMPOUNDSWERE DETECTED. OF THESE, 4 ... IDENTIFIED AS 4-FORMAMIDO-, 4-METHYLFORMAMIDO-, 4-AMINO, & 4-METHYLAMINO-3-CRESYLMETHYLCARBAMATES.|AFTER EXPOSURE OF FLIES TO LABELED MATACIL, (14)CO2 AROSE THROUGH N-DEALKYLATION& HYDROLYSIS TO RESPECTIVE PHENOL & METHYLCARBAMIC ACID. LATTER DECOMP TO CO2 VIA FORMATE ... INCUBATION ... WITH FLY HOMOGENATES & NADPH2 GAVE RISE TO 4-FORMAMIDO-, 4-METHYLFORMAMIDO-, 4-AMINO-, & 4-METHYLAMINO-3-CRESYL METHYLCARBAMATES.|WHEN LABELED MATACIL WAS ADMIN TO RATS, (14)CO2 WAS OBSERVED. AFTER INCUBATION WITH RAT LIVER MICROSOME-NADPH SYSTEM, MATACIL WAS DEGRADED TO N-HYDROXYMETHYL MATACIL, 4-AMINO-3-CRESYL N-METHYLCARBAMATE, 4-METHYLAMINO-3-CRESYL N-METHYLCARBAMATE.|For more Metabolism/Metabolites (Complete) data for AMINOCARB (6 total), please visit the HSDB record page.

Carbamylation of acetylcholinesterase produces accumulation of acetylcholine and the picture of muscarine and nicotinic poisoning. /Carbamate pesticides/

Fresh air, rest. Half-upright position. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.

1) ESTABLISH CLEAR AIRWAY & TISSUE OXYGENATION BY ASPIRATION OF SECRETIONS & IF NECESSARY, BY ASSISTED PULMONARY VENTILATION WITH OXYGEN. IMPROVE TISSUE OXYGENATION AS MUCH AS POSSIBLE BEFORE ADMINISTERING ATROPINE TO MINIMIZE THE RISK OF VENTRICULAR FIBRILLATION. /CARBAMATES, CHOLINESTERASE INHIBITORS/|2) ADMIN ATROPINE SULFATE IV, OR IM IF IV INJECTION IS NOT POSSIBLE ... IN MODERATELY SEVERE POISONING: ADULT DOSAGE, INCLUDING CHILDREN OVER 12 YR: 0.4-2.0 MG REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED (TACHYCARDIA, FLUSHING, DRY MOUTH, MYDRIASIS). MAINTAIN ATROPINIZATION BY REPEATED DOSES FOR 2-12 HR, OR LONGER, DEPENDING ON SEVERITY OF POISONING ... DOSAGE FOR CHILDREN UNDER 12 YEARS: 0.05 MG/KG BODY WT REPEATED EVERY 15 MIN UNTIL ATROPINIZATION IS ACHIEVED. MAINTAIN ATROPINIZATION WITH REPEATED DOSAGE OF 0.02-0.05 MG/KG. SEVERELY POISONED INDIVIDUALS MAY EXHIBIT REMARKABLE TOLERANCE TO ATROPINE; TWICE THE DOSES SUGGESTED ABOVE MAY BE NEEDED ... . /CARBAMATES, CHOLINESTERASE INHIBITORS/|3. PRALIDOXIME (PROTOPAM-AYERST, 2-PAM) IS OF DOUBTFUL VALUE IN POISONINGS BY CARBAMATE INHIBITORS OF CHOLINESTERASE. ATROPINE ALONE IS ALMOST ALWAYS AN ADEQUATE ANTIDOTE. PRALIDOXIME IS PROBABLY CONTRAINDICATED IN POISONINGS BY CARBARYL, SPECIFICALLY. IF VICTIM OF CARBAMATE POISONING EXHIBITS SEVERE MUSCLE WEAKNESS &/OR RESPIRATORY DEPRESSION, OR IF POISONING INVOLVES A COMBINATION OF CARBAMATE & ORGANOPHOSPHATE, A DILUTE SOLUTION OF PRALIDOXIME (TOTAL DOSE IN 250 ML 5% GLUCOSE SOLN) MAY BE GIVEN CAUTIOUSLY IV. THE INFUSION SHOULD BE TERMINATED IF PATIENT'S CONDITION WORSENS. PRALIDOXIME DOSAGE: ADULTS, 1.0 G; FOR CHILDREN UNDER 12 YR, 20-50 MG/KG. 4. OBSERVE TREATED PATIENTS CLOSELY AT LEAST 24 HR TO INSURE THAT SYMPTOMS (POSSIBLY PULMONARY EDEMA) DO NOT RECUR AS ATROPINIZATION WEARS OFF. IN VERY SEVERE POISONINGS, METABOLIC DISPOSITION OF TOXICANT MAY REQUIRE SEVERAL HR OR DAYS DURING WHICH ATROPINIZATION MUST BE MAINTAINED. /CARBAMATES, CHOLINESTERASE INHIBITORS/|5. BATHE & SHAMPOO VICTIM WITH SOAP & WATER IF THERE IS ANY CHANCE THAT SKIN & HAIR ARE CONTAMINATED. 6. IF PESTICIDE HAS BEEN INGESTED IN QUANTITY SUFFICIENT TO CAUSE POISONING, EMPTY THE STOMACH & INTESTINE. A. IF VICTIM IS ALERT & RESPIRATION IS NOT DEPRESSED, GIVE SYRUP OF IPECAC, FOLLOWED BY 1-2 GLASSES OF WATER TO INDUCE VOMITING; ADULTS (INCLUDING CHILDREN OVER 12), 30 ML; CHILDREN (UNDER 12 YR), 15 ML. CAUTION: OBSERVE VICTIM CLOSELY AFTER ADMIN IPECAC, IF CONSCIOUSNESS LEVEL DECLINES, OR IF VOMITING HAS NOT OCCURRED IN 15 MIN, PROCEED IMMEDIATELY TO INTUBATE THE STOMACH. FOLLOWING EMESIS, HAVE VICTIM DRINK A SUSPENSION OF /PRC: 30 G ACTIVATED CHARCOAL IN 3-4 OZ OF WATER (CHILDREN), 100 G IN 8-10 OZ OF WATER (ADULTS)/ ... TO BIND TOXICANT REMAINING IN THE GI TRACT. /CARBAMATES, CHOLINESTERASE INHIBITORS/|For more Antidote and Emergency Treatment (Complete) data for AMINOCARB (6 total), please visit the HSDB record page.

Symptomatology: 1. Nausea, vomiting, abdominal cramps, diarrhea & excessive salivation ... sweating. 2. Lassitude & weakness. 3. Rhinorrhea and sensation of tightness in chest may occur with inhalation exposure. 4. Blurring or dimness of vision. Miosis ... tearing, ciliary muscle spasm, loss of accommodation and ocular pain. None of these ... signs ... is dependable for diagnosis. Mydriasis may be seen ... 5. Loss of muscle coordination, slurring of speech, fasciculation & twitching of muscles. 6. Difficulty in breathing, excessive secretions of saliva and of resp tract mucus, oronasal frothing, cyanosis, pulmonary rales & rhonchi, and hypertension. 7. ... Jerky movements, incontinence, convulsions and coma. 8. Death ... due to resp arrest of central origin, paralysis of resp muscles, intense bronchoconstriction or all three. /Carbaryl/

4-dimethylamino-3-tolyl-N-methylcarbamate

The substance can be absorbed into the body through the skin and by ingestion.

See Ingestion.

MAY BE ABSORBED! See Ingestion.

100% AS AN INSECTICIDE IN CONTROL OF FOREST PESTS INCL SPRUCE WEBWORM & JACK PINE BUDWORM (1974)

USEPA/OPP Pesticide Code 044401; Trade Names: Matacil, Bay 44646, A-363, ENT-25784.|WETTABLE POWDER

A NON-SYSTEMIC INSECTICIDE, MAINLY USED AGAINST LEPIDOPTEROUS LARVAE AND OTHER CHEWING INSECTS; GENERALLY RECOMMENDED AT 75 G AI/100 L.|SOME ACARICIDAL ACTIVITY. GROUND AND AERIAL APPLICATIONS OF ULTRA-LOW VOL SPRAYS AT RATES OF 1-3 OZ ACTIVE INGREDIENT PER ACRE PROVIDES EFFECTIVE CONTROL OF JACK PINE BUDWORM AND SPRUCE BUDWORM.|Discontinued 1989 by Bayer AG.

PRODUCT ANALYSIS IS BY HPLC OR BY UV SPECTROSCOPY. RESIDUES MAY BE DETERMINED UV SPECTROSCOPY OR BY GLC OF A DERIVATIVE.|Macro: ... By IR spectrophotometry, a 5.71 um. Residue: Forest foliage, soil & water, a GC method using a detector specific for nitrogen.|Aminocarb and /its/ respective hydrolysis products were determined simultaneously in water by GC using a nitrogen-phosphorus selective detector.|Determination of aminocarb technical and pesticide formulations by liquid chromatographic method using a n-butrophenone as internal standard.

INSECTICIDES